Protein: SYVM
Valine--tRNA ligase, mitochondrial (EC 6.1.1.9) (Valyl-tRNA synthetase) (ValRS) (Valyl-tRNA synthetase-like)

Gene: SYVM, VARS2
Organism: Homo sapiens
Interactions: 103
UniProt ID: Q5ST30

Gene Ontology (top 5):
GO:0002161 - aminoacyl-tRNA editing activity
GO:0004832 - valine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1131499

ABI2
Abl interactor 2

4

2

High-throughput

0.705

High

209074

NCK2
Cytoplasmic protein NCK2

3

3

High-throughput

0.675

High

235520

VINEX
Vinexin

3

0

High-throughput

0.646

High

326324

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

2

1

High-throughput

0.628

High

1050973

ICT1
Large ribosomal subunit protein mL62

2

2

High-throughput

0.611

High

1131460

ABI1
Abl interactor 1

2

3

High-throughput

0.606

High

1131484

UCK2
Uridine-cytidine kinase 2

2

0

High-throughput

0.602

High

262840

CISY
Citrate synthase, mitochondrial

2

2

High-throughput

0.584

High

1086597

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

2

High-throughput

0.584

High

258719

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

2

2

High-throughput

0.574

High

1131473

IMP1L
Mitochondrial inner membrane protease subunit 1

1

4

High-throughput

0.554

High

1131503

ABI3
ABI gene family member 3

2

2

High-throughput

0.553

High

203955

HTRA2
Serine protease HTRA2, mitochondrial

1

1

High-throughput

0.536

High

646415

KAD4
Adenylate kinase 4, mitochondrial

1

2

High-throughput

0.536

High

815383

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

2

High-throughput

0.536

High

1131505

AMACR
Alpha-methylacyl-CoA racemase

1

1

High-throughput

0.536

High

1131506

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

454706

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

787251

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

1

High-throughput

0.508

High

1131476

IMP2L
Mitochondrial inner membrane protease subunit 2

1

4

High-throughput

0.506

High

172029

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.489

High

1131471

RT24
Small ribosomal subunit protein uS3m

1

1

High-throughput

0.489

High

1131494

B2L12
Bcl-2-like protein 12

1

1

High-throughput

0.489

High

59198

VWA8
von Willebrand factor A domain-containing protein 8

1

2

High-throughput

0.479

High

63370

MET15
12S rRNA N4-methylcytidine

1

1

High-throughput

0.479

High

264926

MPPB
Mitochondrial-processing peptidase subunit beta

1

5

High-throughput

0.479

High

270048

RF1M
Peptide chain release factor 1, mitochondrial

1

9

High-throughput

0.479

High

325208

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

3

High-throughput

0.479

High

327459

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

3

High-throughput

0.479

High

336876

OTC
Ornithine transcarbamylase, mitochondrial

1

3

High-throughput

0.479

High

374357

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.479

High

440556

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

3

High-throughput

0.479

High

486542

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

2

High-throughput

0.479

High

499806

CH60
60 kDa heat shock protein, mitochondrial

1

4

High-throughput

0.479

High

525529

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

2

High-throughput

0.479

High

718922

PHB1
Prohibitin 1

1

4

High-throughput

0.479

High

751672

GRP75
Stress-70 protein, mitochondrial

1

5

High-throughput

0.479

High

777587

MDHM
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.479

High

789827

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

2

High-throughput

0.479

High

799244

EFTS
Elongation factor Ts, mitochondrial

1

2

High-throughput

0.479

High

803130

IF2M
Translation initiation factor IF-2, mitochondrial

1

9

High-throughput

0.479

High

827418

EFTU
Elongation factor Tu, mitochondrial

1

11

High-throughput

0.479

High

958932

TFAM
Transcription factor A, mitochondrial

1

2

High-throughput

0.479

High

981281

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

2

High-throughput

0.479

High

990101

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

High-throughput

0.479

High

994498

QOR
Quinone oxidoreductase

1

3

High-throughput

0.479

High

1014390

MPPA
Mitochondrial-processing peptidase subunit alpha

1

5

High-throughput

0.479

High

1017916

GRSF1
G-rich sequence factor 1

1

4

High-throughput

0.479

High

1020450

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

7

High-throughput

0.479

High

1045773

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

2

High-throughput

0.479

High

1062234

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

9

High-throughput

0.479

High

1067979

PDK1
[Pyruvate dehydrogenase

1

2

High-throughput

0.479

High

1074600

SURF1
Surfeit locus protein 1

1

2

High-throughput

0.479

High

1128145

SYAM
Alanine--tRNA ligase, mitochondrial

1

4

High-throughput

0.479

High

1131454

MRM1
rRNA methyltransferase 1, mitochondrial

1

2

High-throughput

0.479

High

1131455

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

5

High-throughput

0.479

High

1131457

COX15
Heme A synthase COX15

1

2

High-throughput

0.479

High

1131458

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

9

High-throughput

0.479

High

1131459

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.479

High

1131461

SNIP1
Smad nuclear-interacting protein 1

1

1

High-throughput

0.479

High

1131463

FAKD4
FAST kinase domain-containing protein 4

1

9

High-throughput

0.479

High

1131464

MCUR1
Mitochondrial calcium uniporter regulator 1

1

5

High-throughput

0.479

High

1131465

CHCH1
Small ribosomal subunit protein mS37

1

1

High-throughput

0.479

High

1131466

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

5

High-throughput

0.479

High

1131467

FMT
Methionyl-tRNA formyltransferase, mitochondrial

1

1

High-throughput

0.479

High

1131469

RRFM
Ribosome-recycling factor, mitochondrial

1

2

High-throughput

0.479

High

1131470

MTEF3
Transcription termination factor 3, mitochondrial

1

2

High-throughput

0.479

High

1131472

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

4

High-throughput

0.479

High

1131474

TEFM
Transcription elongation factor, mitochondrial

1

1

High-throughput

0.479

High

1131475

EFGM
Elongation factor G, mitochondrial

1

7

High-throughput

0.479

High

1131477

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

6

High-throughput

0.479

High

1131478

TACO1
Translational activator of cytochrome c oxidase 1

1

2

High-throughput

0.479

High

1131480

MTG1
Mitochondrial ribosome-associated GTPase 1

1

1

High-throughput

0.479

High

1131481

TR61B
tRNA

1

2

High-throughput

0.479

High

1131482

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

2

High-throughput

0.479

High

1131483

RT26
Small ribosomal subunit protein mS26

1

2

High-throughput

0.479

High

1131485

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1131486

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

5

High-throughput

0.479

High

1131487

IF3M
Translation initiation factor IF-3, mitochondrial

1

2

High-throughput

0.479

High

1131488

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

1

High-throughput

0.479

High

1131489

MTG2
Mitochondrial ribosome-associated GTPase 2

1

4

High-throughput

0.479

High

1131492

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

2

High-throughput

0.479

High

1131493

SFXN1
Sideroflexin-1

1

1

High-throughput

0.479

High

1131495

NGRN
Neugrin

1

1

High-throughput

0.479

High

1131496

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

4

High-throughput

0.479

High

1131497

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

3

High-throughput

0.479

High

1131498

RMND1
Required for meiotic nuclear division protein 1 homolog

1

2

High-throughput

0.479

High

1131500

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

1131502

MRES1
Mitochondrial transcription rescue factor 1

1

2

High-throughput

0.479

High

1131504

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

9

High-throughput

0.479

High

1131507

RM11
Large ribosomal subunit protein uL11m

1

3

High-throughput

0.479

High

173040

RT12
Small ribosomal subunit protein uS12m

1

2

High-throughput

0.437

High

720645

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

1131456

CH082
UPF0598 protein C8orf82

1

2

High-throughput

0.437

High

1131479

CQ080
Mitochondrial nucleoid-associated protein 1

1

1

High-throughput

0.437

High

1131490

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

1131491

MET17
Ribosome assembly protein METTL17, mitochondrial

1

2

High-throughput

0.437

High

1131462

MAL2
Protein MAL2

1

0

High-throughput

0.299

High

1131468

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.299

High

598955

FPR1
fMet-Leu-Phe receptor

1

0

High-throughput

0.279

Low

674030

V2R
Vasopressin V2 receptor

1

0

High-throughput

0.279

Low

1077632

KISS1
Metastasis-suppressor KiSS-1

1

0

High-throughput

0.279

Low

1131501

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024