Protein: SHCBP
SHC SH2 domain-binding protein 1

Gene: SHCBP, SHCBP1
Organism: Homo sapiens
Interactions: 54
UniProt ID: Q8NEM2

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005819 - spindle
GO:0008543 - fibroblast growth factor receptor signaling pathway
GO:0030496 - midbody
GO:0042169 - SH2 domain binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1337564

RGAP1
Rac GTPase-activating protein 1

6

1

High-throughput

0.735

High

966637

1433G
14-3-3 protein gamma

5

8

High-throughput

0.716

High

1035790

KIF23
Kinesin-like protein KIF23

3

1

High-throughput

0.667

High

1049577

1433F
14-3-3 protein eta

3

8

High-throughput

0.662

High

603315

KPCA
Protein kinase C alpha type

2

1

High-throughput

0.628

High

436704

KPCB
Protein kinase C beta type

2

1

High-throughput

0.621

High

971797

1433E
14-3-3 protein epsilon

2

1

Small-scale

0.611

High

69805

ZN785
Zinc finger protein 785

2

2

High-throughput

0.574

High

600508

ZNF3
Zinc finger protein 3

2

1

High-throughput

0.574

High

1337558

ZN563
Zinc finger protein 563

2

1

High-throughput

0.574

High

1337566

ZN408
Zinc finger protein 408

2

1

High-throughput

0.574

High

691261

1433T
14-3-3 protein theta

1

8

High-throughput

0.536

High

730067

1433B
14-3-3 protein beta/alpha

1

8

High-throughput

0.536

High

990516

1433Z
14-3-3 protein zeta/delta

1

8

High-throughput

0.536

High

711379

SHC1
SHC-transforming protein 1

1

1

Small-scale

0.523

High

730777

1433S
14-3-3 protein sigma

1

8

High-throughput

0.515

High

872545

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.513

High

1257881

UBP49
Ubiquitin carboxyl-terminal hydrolase 49

1

0

High-throughput

0.513

High

913729

ZN136
Zinc finger protein 136

1

1

High-throughput

0.489

High

1327322

ZN276
Zinc finger protein 276

1

1

High-throughput

0.489

High

1254708

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1337567

ANLN
Anillin

1

1

High-throughput

0.479

High

242328

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

315790

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

372615

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

1140582

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1337561

SH3K1
SH3 domain-containing kinase-binding protein 1

1

0

High-throughput

0.458

High

1337563

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

1337565

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

1337570

DS13B
Dual specificity protein phosphatase 13B

1

0

High-throughput

0.458

High

1210915

CE170
Centrosomal protein of 170 kDa

1

1

High-throughput

0.445

High

998563

H31
Histone H3.1

1

1

High-throughput

0.437

High

1273847

MICA3
[F-actin]-monooxygenase MICAL3

1

0

Small-scale

0.426

High

883618

CENPA
Histone H3-like centromeric protein A

1

1

Small-scale

0.407

High

1027923

PSG9
Pregnancy-specific beta-1-glycoprotein 9

3

0

High-throughput

0.347

High

63770

KRBA1
Protein KRBA1

2

0

High-throughput

0.328

High

438093

GLPB
Glycophorin-B

2

0

High-throughput

0.328

High

1211318

NOL9
Polynucleotide 5'-hydroxyl-kinase NOL9

2

0

High-throughput

0.328

High

1252630

ZN574
Zinc finger protein 574

2

0

High-throughput

0.328

High

1337562

ZN414
Zinc finger protein 414

2

0

High-throughput

0.328

High

1337568

ZN331
Zinc finger protein 331

2

0

High-throughput

0.328

High

1337560

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

High-throughput

0.282

High

854170

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.279

Low

964033

COPZ1
Coatomer subunit zeta-1

1

0

High-throughput

0.279

Low

1311000

SULF2
Extracellular sulfatase Sulf-2

1

0

High-throughput

0.279

Low

1337569

ASIC5
Bile acid-sensitive ion channel

1

0

High-throughput

0.279

Low

1337571

ZN777
Zinc finger protein 777

1

0

High-throughput

0.279

Low

106305

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

589196

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

695978

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

867284

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.249

Low

1227084

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.249

Low

1337559

RL36L
Ribosomal protein eL42-like

1

0

High-throughput

0.249

Low

1130348

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025