Protein: UBP49
Ubiquitin carboxyl-terminal hydrolase 49 (EC 3.4.19.12) (Deubiquitinating enzyme 49) (Ubiquitin thioesterase 49) (Ubiquitin-specific-processing protease 49)

Gene: UBP49, USP49
Organism: Homo sapiens
Interactions: 72
UniProt ID: Q70CQ1

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0004197 - cysteine-type endopeptidase activity
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1257893

UBP44
Ubiquitin carboxyl-terminal hydrolase 44

3

14

Small-scale

0.847

High

1105979

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

4

4

Small-scale

0.702

High

181637

CETN3
Centrin-3

4

9

Small-scale

0.694

High

177246

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

6

High-throughput

0.691

High

921935

COPA
Coatomer subunit alpha

1

5

High-throughput

0.691

High

832915

CETN2
Centrin-2

3

7

Small-scale

0.667

High

1257878

STING
Stimulator of interferon genes protein

2

6

Small-scale

0.624

High

1257880

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

1

6

High-throughput

0.618

High

968965

PRS8
26S proteasome regulatory subunit 8

1

7

Small-scale

0.618

High

1239176

ZN774
Zinc finger protein 774

2

1

High-throughput

0.606

High

414079

P53
Cellular tumor antigen p53

1

5

Small-scale

0.561

High

417523

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

2

Small-scale

0.558

High

1086167

CETN1
Centrin-1

2

7

Small-scale

0.558

High

187116

PPM1G
Protein phosphatase 1G

1

3

High-throughput

0.536

High

325902

UBR5
E3 ubiquitin-protein ligase UBR5

1

12

High-throughput

0.536

High

334812

IPO7
Importin-7

1

2

High-throughput

0.536

High

605727

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

9

High-throughput

0.536

High

916676

PPP5
Serine/threonine-protein phosphatase 5

1

5

High-throughput

0.536

High

1112064

KRR1
KRR1 small subunit processome component homolog

1

3

High-throughput

0.536

High

1128225

MCM6
DNA replication licensing factor MCM6

1

5

High-throughput

0.536

High

1135254

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

10

High-throughput

0.536

High

1204747

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

4

High-throughput

0.536

High

1257877

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

11

High-throughput

0.536

High

1257883

S39A7
Zinc transporter SLC39A7

1

1

High-throughput

0.536

High

1257886

STALP
AMSH-like protease

1

1

High-throughput

0.536

High

1257887

IPO9
Importin-9

1

2

High-throughput

0.536

High

1257891

NUP85
Nuclear pore complex protein Nup85

1

1

High-throughput

0.536

High

1257900

DICER
Endoribonuclease Dicer

1

8

High-throughput

0.536

High

841802

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.513

High

1157146

PDCD2
Programmed cell death protein 2

1

0

High-throughput

0.513

High

1257881

SHCBP
SHC SH2 domain-binding protein 1

1

0

High-throughput

0.513

High

1163008

H2B2E
Histone H2B type 2-E

1

20

Small-scale

0.501

High

273681

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

6

High-throughput

0.489

High

475485

FA7
Coagulation factor VII

1

2

High-throughput

0.489

High

731409

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.489

High

829439

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

4

High-throughput

0.489

High

1257898

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

4

High-throughput

0.489

High

1257892

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

8

High-throughput

0.481

High

1257899

TRI35
E3 ubiquitin-protein ligase TRIM35

1

9

High-throughput

0.481

High

276697

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

1

3

High-throughput

0.479

High

404154

GCR
Glucocorticoid receptor

1

12

Small-scale

0.479

High

461629

HS90A
Heat shock protein HSP 90-alpha

1

5

High-throughput

0.479

High

504743

FBSP1
F-box/SPRY domain-containing protein 1

1

12

Small-scale

0.479

High

591702

H2AX
Histone H2AX

1

17

Small-scale

0.479

High

703268

MSX1
Homeobox protein MSX-1

1

6

Small-scale

0.479

High

703952

DUS1
Dual specificity protein phosphatase 1

1

3

Small-scale

0.479

High

764850

CTNB1
Catenin beta-1

1

15

Small-scale

0.479

High

1044356

HSF2
Heat shock factor protein 2

1

2

High-throughput

0.479

High

1144041

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.479

High

1155483

EZH2
Histone-lysine N-methyltransferase EZH2

1

5

Small-scale

0.479

High

1257879

NUDC3
NudC domain-containing protein 3

1

2

High-throughput

0.479

High

1257884

HS105
Heat shock protein 105 kDa

1

6

Small-scale

0.479

High

1257888

WRIP1
ATPase WRNIP1

1

3

Small-scale

0.479

High

1257890

AASD1
Alanyl-tRNA editing protein Aarsd1

1

1

High-throughput

0.479

High

1257896

ABC3G
DNA dC->dU-editing enzyme APOBEC-3G

1

1

Small-scale

0.479

High

1257897

CHIP
E3 ubiquitin-protein ligase CHIP

1

7

High-throughput

0.479

High

1257901

RUVB1
RuvB-like 1

1

5

Small-scale

0.479

High

1257904

NS1BP
Influenza virus NS1A-binding protein

1

7

Small-scale

0.479

High

938465

PAX9
Paired box protein Pax-9

1

0

Small-scale

0.458

High

1158394

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.458

High

1257895

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.458

High

1257903

ZHX2
Zinc fingers and homeoboxes protein 2

1

0

Small-scale

0.458

High

76549

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

3

High-throughput

0.437

High

347127

BAG2
BAG family molecular chaperone regulator 2

1

1

Small-scale

0.437

High

1245552

Q6PK50
HSP90AB1 protein

1

7

High-throughput

0.437

High

1257885

Q96BE0
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.437

High

1257889

Q9BPW0
Serine/threonine-protein phosphatase

1

5

High-throughput

0.437

High

1257894

Q9HAV2
Heat shock transcription factor 1

1

1

High-throughput

0.437

High

849466

NAMPT
Nicotinamide phosphoribosyltransferase

2

0

High-throughput

0.316

High

1257882

PTCD2
Pentatricopeptide repeat-containing protein 2, mitochondrial

2

0

High-throughput

0.316

High

1165230

IMPG1
Interphotoreceptor matrix proteoglycan 1

1

0

High-throughput

0.279

Low

1257902

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025