Protein: SH3K1
SH3 domain-containing kinase-binding protein 1 (Regulator of ubiquitous kinase) (Ruk) (SH3-containing, expressed in tumorigenic astrocytes)

Gene: SH3K1, Sh3kbp1
Organism: Mus musculus
Interactions: 20
UniProt ID: Q8R550

Gene Ontology (top 5):
GO:0005856 - cytoskeleton
GO:0005911 - cell-cell junction
GO:0005925 - focal adhesion
GO:0006915 - apoptotic process
GO:0007010 - cytoskeleton organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1223673

DLG4
Disks large homolog 4

3

11

Small-scale

0.650

High

1341637

DLGP1
Disks large-associated protein 1

2

14

High-throughput

0.611

High

651561

CBL
E3 ubiquitin-protein ligase CBL

2

20

Small-scale

0.571

High

312841

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.536

High

1013681

TNIK
Traf2 and NCK-interacting protein kinase

1

20

High-throughput

0.536

High

958595

DRD2
D(2) dopamine receptor

1

8

Small-scale

0.515

High

104617

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

12

High-throughput

0.479

High

810535

DYN1
Dynamin-1

1

20

Small-scale

0.479

High

810555

DYN2
Dynamin-2

1

20

Small-scale

0.479

High

1224166

SH3G2
Endophilin-A1

1

20

Small-scale

0.479

High

1296146

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

13

High-throughput

0.479

High

1341638

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

20

Small-scale

0.479

High

1341641

SPY2
Protein sprouty homolog 2

1

9

Small-scale

0.479

High

1221245

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.457

High

1341640

SRCN1
SRC kinase signaling inhibitor 1

1

5

High-throughput

0.445

High

266853

ATX2
Ataxin-2

1

15

Small-scale

0.437

High

1022132

DAB2
Disabled homolog 2

1

20

Small-scale

0.437

High

1190900

CDKL5
Cyclin-dependent kinase-like 5

1

2

High-throughput

0.437

High

1341639

BLNK
B-cell linker protein

1

20

High-throughput

0.417

High

1298741

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025