Protein: SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship)

Gene: SHIP1, Inpp5d
Organism: Mus musculus
Interactions: 38
UniProt ID: Q9ES52

Gene Ontology (top 5):
GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0004445 - inositol-polyphosphate 5-phosphatase activity
GO:0005829 - cytosol
GO:0005856 - cytoskeleton
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1022228

SHC1
SHC-transforming protein 1

6

20

Small-scale

0.944

High

362455

ABL1
Tyrosine-protein kinase ABL1

2

20

Small-scale

0.806

High

868845

CRKL
Crk-like protein

1

20

Small-scale

0.724

High

1189766

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

1

High-throughput

0.646

High

1021486

DOK1
Docking protein 1

2

7

Small-scale

0.639

High

651578

CBL
E3 ubiquitin-protein ligase CBL

3

3

Small-scale

0.633

High

1424431

SLAF1
Signaling lymphocytic activation molecule

2

20

Small-scale

0.629

High

431370

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.618

High

686987

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

17

Small-scale

0.618

High

767030

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

2

Small-scale

0.618

High

778179

BTK
Tyrosine-protein kinase BTK

1

20

Small-scale

0.618

High

1221257

GRB2
Growth factor receptor-bound protein 2

1

20

Small-scale

0.618

High

1222339

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

9

Small-scale

0.618

High

1223513

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

3

Small-scale

0.618

High

1424433

ZO2
Tight junction protein 2

1

3

Small-scale

0.618

High

1298745

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

3

High-throughput

0.590

High

1247589

CLM8
CMRF35-like molecule 8

1

0

Small-scale

0.586

High

1021933

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

10

Small-scale

0.553

High

1221488

LCP2
Lymphocyte cytosolic protein 2

1

0

High-throughput

0.546

High

236538

TYOBP
TYRO protein tyrosine kinase-binding protein

1

0

Small-scale

0.537

High

267123

DOK2
Docking protein 2

1

7

High-throughput

0.536

High

1423939

Q9D031
Ras suppressor protein 1

1

0

Small-scale

0.517

High

770704

CD22
B-cell receptor CD22

1

5

Small-scale

0.479

High

1189154

STING
Stimulator of interferon genes protein

1

2

High-throughput

0.479

High

1297910

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.479

High

1341638

SH3K1
SH3 domain-containing kinase-binding protein 1

1

20

Small-scale

0.479

High

1408913

LPXN
Leupaxin

1

2

Small-scale

0.479

High

1424404

PARVG
Gamma-parvin

1

7

Small-scale

0.479

High

1424432

DOK3
Docking protein 3

1

7

Small-scale

0.479

High

723746

CTND1
Catenin delta-1

1

0

Small-scale

0.458

High

821234

CSF3R
Granulocyte colony-stimulating factor receptor

1

0

Small-scale

0.458

High

1030287

SC23A
Protein transport protein Sec23A

1

0

Small-scale

0.458

High

1282645

FACD2
Fanconi anemia group D2 protein homolog

1

0

High-throughput

0.458

High

1408685

FOXP3
Forkhead box protein P3

1

0

High-throughput

0.458

High

465764

FCGR2
Low affinity immunoglobulin gamma Fc region receptor II

1

9

Small-scale

0.445

High

958559

ACTZ
Alpha-centractin

1

7

Small-scale

0.437

High

236859

LAT
Linker for activation of T-cells family member 1

1

0

High-throughput

0.426

High

1408798

DCTN2
Dynactin subunit 2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025