Protein: SSDH
Succinate-semialdehyde dehydrogenase, mitochondrial (EC 1.2.1.24) (Aldehyde dehydrogenase family 5 member A1) (NAD(+)-dependent succinic semialdehyde dehydrogenase)

Gene: SSDH, ALDH5A1
Organism: Homo sapiens
Interactions: 46
UniProt ID: P51649

Gene Ontology (top 5):
GO:0004777 - succinate-semialdehyde dehydrogenase (NAD+) activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006105 - succinate metabolic process
GO:0006536 - glutamate metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

906229

SSDH
Succinate-semialdehyde dehydrogenase, mitochondrial

1

15

Small-scale

0.647

High

906234

FGL1
Fibrinogen-like protein 1

4

3

High-throughput

0.630

High

906238

OXLD1
Oxidoreductase-like domain-containing protein 1

2

0

High-throughput

0.585

High

241140

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.584

High

906251

MSRB2
Methionine-R-sulfoxide reductase B2, mitochondrial

2

0

High-throughput

0.576

High

906241

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

3

High-throughput

0.536

High

906242

AHI1
Jouberin

1

8

High-throughput

0.536

High

105603

APRIO
Alternative prion protein

2

4

High-throughput

0.533

High

906230

TERA
Transitional endoplasmic reticulum ATPase

2

6

Small-scale

0.521

High

225189

GATC
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial

1

0

High-throughput

0.513

High

906236

RM23
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.513

High

906243

RM50
Large ribosomal subunit protein mL50

1

0

High-throughput

0.513

High

317405

KPCD3
Serine/threonine-protein kinase D3

1

2

High-throughput

0.489

High

896956

MAP2
Methionine aminopeptidase 2

1

1

High-throughput

0.489

High

906232

SRP54
Signal recognition particle subunit SRP54

1

1

High-throughput

0.489

High

403923

GCR
Glucocorticoid receptor

1

2

High-throughput

0.479

High

906237

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

3

High-throughput

0.479

High

906245

FAKD4
FAST kinase domain-containing protein 4

1

1

High-throughput

0.479

High

257393

PAGE4
P antigen family member 4

1

0

High-throughput

0.458

High

185540

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

4

High-throughput

0.457

High

529378

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.445

High

142902

NFIB
Nuclear factor 1 B-type

1

3

High-throughput

0.437

High

473865

NFIC
Nuclear factor 1 C-type

1

3

High-throughput

0.437

High

550928

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.437

High

588247

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

767741

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

798866

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.437

High

906233

UBC12
NEDD8-conjugating enzyme Ubc12

1

1

High-throughput

0.437

High

906240

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

906248

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.437

High

626127

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

0

High-throughput

0.426

High

404733

PRIO
Major prion protein

1

1

High-throughput

0.407

High

429555

JUN
Transcription factor Jun

1

3

High-throughput

0.407

High

906239

CP135
Centrosomal protein of 135 kDa

1

3

High-throughput

0.407

High

906249

XCT
Cystine/glutamate transporter

1

1

High-throughput

0.407

High

848850

MAGAB
Melanoma-associated antigen 11

1

0

High-throughput

0.282

High

906246

CLIC6
Chloride intracellular channel protein 6

1

0

High-throughput

0.282

High

906244

GLMP
Glycosylated lysosomal membrane protein

1

0

High-throughput

0.279

Low

906247

IRAK4
Interleukin-1 receptor-associated kinase 4

1

0

High-throughput

0.279

Low

906250

GPR55
G-protein coupled receptor 55

1

0

High-throughput

0.279

Low

408750

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.249

Low

536786

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.249

Low

694972

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

906231

KLF3
Krueppel-like factor 3

1

0

High-throughput

0.249

Low

906235

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025