Protein: IRAK4
Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64)

Gene: IRAK4
Organism: Homo sapiens
Interactions: 47
UniProt ID: Q9NWZ3

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0002224 - toll-like receptor signaling pathway
GO:0002446 - neutrophil mediated immunity
GO:0002755 - MyD88-dependent toll-like receptor signaling pathway
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

905692

IRAK1
Interleukin-1 receptor-associated kinase 1

13

19

Small-scale

0.984

High

1451573

IRAK4
Interleukin-1 receptor-associated kinase 4

3

19

Small-scale

0.818

High

210210

IRAK2
Interleukin-1 receptor-associated kinase-like 2

2

20

Small-scale

0.811

High

126338

TLR4
Toll-like receptor 4

2

20

Small-scale

0.789

High

1407677

MYD88
Myeloid differentiation primary response protein MyD88

21

10

Small-scale

0.767

High

1390443

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

9

2

Small-scale

0.756

High

252291

TLR5
Toll-like receptor 5

2

20

Small-scale

0.754

High

1031682

ILRL1
Interleukin-1 receptor-like 1

3

2

Small-scale

0.657

High

1437657

PELI2
E3 ubiquitin-protein ligase pellino homolog 2

2

2

Small-scale

0.653

High

946679

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

2

1

Small-scale

0.640

High

691477

1433T
14-3-3 protein theta

1

2

Small-scale

0.618

High

1451576

IRAK3
Interleukin-1 receptor-associated kinase 3

1

20

High-throughput

0.618

High

320415

SASH1
SAM and SH3 domain-containing protein 1

1

0

Small-scale

0.586

High

572853

NCF1
Neutrophil cytosol factor 1

1

0

Small-scale

0.586

High

1397726

ZN597
Zinc finger protein 597

2

0

High-throughput

0.580

High

1420559

TRIM7
E3 ubiquitin-protein ligase TRIM7

2

0

High-throughput

0.580

High

1451574

I36RA
Interleukin-36 receptor antagonist protein

2

0

High-throughput

0.580

High

1451575

TRAF6
TNF receptor-associated factor 6

2

0

Small-scale

0.576

High

1142482

RAGE
Advanced glycosylation end product-specific receptor

1

1

Small-scale

0.536

High

693372

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

0

High-throughput

0.518

High

165829

TR13B
Tumor necrosis factor receptor superfamily member 13B

1

1

Small-scale

0.515

High

575766

IL1R1
Interleukin-1 receptor type 1

1

2

Small-scale

0.515

High

162718

ANM5
Protein arginine N-methyltransferase 5

1

0

High-throughput

0.513

High

402805

CYTB
Cystatin-B

1

0

High-throughput

0.513

High

713468

SPB3
Serpin B3

1

0

High-throughput

0.513

High

913601

KIF11
Kinesin-like protein KIF11

1

0

High-throughput

0.513

High

521978

H14
Histone H1.4

1

5

Small-scale

0.501

High

595615

H15
Histone H1.5

1

5

Small-scale

0.501

High

595894

H13
Histone H1.3

1

5

Small-scale

0.501

High

596388

H12
Histone H1.2

1

5

Small-scale

0.501

High

649442

H1T
Histone H1t

1

5

Small-scale

0.501

High

1037411

H11
Histone H1.1

1

5

Small-scale

0.501

High

388093

MBP
Myelin basic protein

1

0

Small-scale

0.480

High

1109572

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

1

0

Small-scale

0.480

High

1451577

NEMO
NF-kappa-B essential modulator

1

0

Small-scale

0.480

High

1014869

HPCA
Neuron-specific calcium-binding protein hippocalcin

1

1

High-throughput

0.479

High

1324349

PELI3
E3 ubiquitin-protein ligase pellino homolog 3

1

2

Small-scale

0.479

High

975592

TBPL1
TATA box-binding protein-like 1

1

0

High-throughput

0.473

High

905201

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

1108208

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1308420

UN5CL
UNC5C-like protein

1

0

Small-scale

0.458

High

789677

HPCL1
Hippocalcin-like protein 1

1

1

High-throughput

0.437

High

868780

LEG7
Galectin-7

1

0

High-throughput

0.426

High

516726

VSIG8
V-set and immunoglobulin domain-containing protein 8

2

0

High-throughput

0.305

High

906247

SSDH
Succinate-semialdehyde dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1331293

RN152
E3 ubiquitin-protein ligase RNF152

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025