Protein: UB2D4
Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4)

Gene: UB2D4, UBE2D4
Organism: Homo sapiens
Interactions: 129
UniProt ID: Q9Y2X8

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0004842 - ubiquitin-protein transferase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1377465

RNF11
RING finger protein 11

7

20

High-throughput

0.965

High

1356055

TRIM1
Probable E3 ubiquitin-protein ligase MID2

7

20

Small-scale

0.964

High

1200380

DTX2
Probable E3 ubiquitin-protein ligase DTX2

6

20

High-throughput

0.957

High

1285495

RNF25
E3 ubiquitin-protein ligase RNF25

5

14

High-throughput

0.935

High

1377467

RN115
E3 ubiquitin-protein ligase RNF115

5

20

High-throughput

0.932

High

1291615

OTUB1
Ubiquitin thioesterase OTUB1

5

10

High-throughput

0.931

High

1307272

RNF5
E3 ubiquitin-protein ligase RNF5

4

20

High-throughput

0.911

High

1242076

ZNRF1
E3 ubiquitin-protein ligase ZNRF1

4

20

High-throughput

0.904

High

175730

TRI18
E3 ubiquitin-protein ligase Midline-1

4

20

Small-scale

0.896

High

607190

UBA1
Ubiquitin-like modifier-activating enzyme 1

4

20

Small-scale

0.888

High

1354303

RNF14
E3 ubiquitin-protein ligase RNF14

3

20

High-throughput

0.873

High

1327018

MKRN2
E3 ubiquitin-protein ligase makorin-2

3

14

High-throughput

0.871

High

1313520

RN126
E3 ubiquitin-protein ligase RNF126

3

20

High-throughput

0.862

High

988038

RING1
E3 ubiquitin-protein ligase RING1

3

20

High-throughput

0.861

High

1238409

DTX3
Probable E3 ubiquitin-protein ligase DTX3

3

20

High-throughput

0.861

High

1283434

RN166
E3 ubiquitin-protein ligase RNF166

3

20

High-throughput

0.861

High

1292368

RN185
E3 ubiquitin-protein ligase RNF185

3

20

High-throughput

0.861

High

1304199

RING2
E3 ubiquitin-protein ligase RING2

3

20

High-throughput

0.861

High

1318358

TRIM8
E3 ubiquitin-protein ligase TRIM8

3

20

High-throughput

0.861

High

1349753

RN181
E3 ubiquitin-protein ligase RNF181

3

20

High-throughput

0.861

High

941604

RNF4
E3 ubiquitin-protein ligase RNF4

3

20

Small-scale

0.852

High

1204911

TRI50
E3 ubiquitin-protein ligase TRIM50

3

20

Small-scale

0.845

High

1235248

RNF10
E3 ubiquitin-protein ligase RNF10

2

20

High-throughput

0.817

High

1160856

RFWD3
E3 ubiquitin-protein ligase RFWD3

2

20

High-throughput

0.815

High

1169203

RN111
E3 ubiquitin-protein ligase Arkadia

2

20

High-throughput

0.815

High

1356614

AMFR
E3 ubiquitin-protein ligase AMFR

2

20

High-throughput

0.815

High

1282543

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

2

20

Small-scale

0.800

High

1318738

TRIM2
Tripartite motif-containing protein 2

2

20

Small-scale

0.800

High

1332598

RN167
E3 ubiquitin-protein ligase RNF167

2

20

Small-scale

0.800

High

1334693

UBTD1
Ubiquitin domain-containing protein 1

4

5

Small-scale

0.789

High

1252560

LNX1
E3 ubiquitin-protein ligase LNX

2

4

High-throughput

0.783

High

1317493

TRI54
Tripartite motif-containing protein 54

2

20

High-throughput

0.783

High

1355338

MKRN1
E3 ubiquitin-protein ligase makorin-1

2

14

High-throughput

0.783

High

229121

PRKN
E3 ubiquitin-protein ligase parkin

2

20

Small-scale

0.768

High

476604

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

20

Small-scale

0.768

High

262201

TRIM3
Tripartite motif-containing protein 3

2

20

Small-scale

0.767

High

1336390

TRI39
E3 ubiquitin-protein ligase TRIM39

5

20

High-throughput

0.726

High

1260455

UBTD2
Ubiquitin domain-containing protein 2

2

5

High-throughput

0.700

High

122275

RN103
E3 ubiquitin-protein ligase RNF103

1

20

High-throughput

0.698

High

196372

PJA2
E3 ubiquitin-protein ligase Praja-2

1

20

High-throughput

0.698

High

207572

RNF13
E3 ubiquitin-protein ligase RNF13

1

20

High-throughput

0.698

High

230183

MGRN1
E3 ubiquitin-protein ligase MGRN1

1

6

High-throughput

0.698

High

301058

RNF37
RING finger protein 37

1

5

High-throughput

0.698

High

312679

ARI2
E3 ubiquitin-protein ligase ARIH2

1

20

High-throughput

0.698

High

317692

CNOT4
CCR4-NOT transcription complex subunit 4

1

11

High-throughput

0.698

High

957802

XIAP
E3 ubiquitin-protein ligase XIAP

1

20

High-throughput

0.698

High

1023586

MKRN3
Probable E3 ubiquitin-protein ligase makorin-3

1

14

High-throughput

0.698

High

1048973

UBE4A
Ubiquitin conjugation factor E4 A

1

20

High-throughput

0.698

High

1052807

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

20

High-throughput

0.698

High

1148281

RNF43
E3 ubiquitin-protein ligase RNF43

1

20

High-throughput

0.698

High

1163056

TRAF7
E3 ubiquitin-protein ligase TRAF7

1

8

High-throughput

0.698

High

1165227

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

6

High-throughput

0.698

High

1170316

ARK2C
E3 ubiquitin-protein ligase ARK2C

1

20

High-throughput

0.698

High

1204871

GOLI
E3 ubiquitin-protein ligase RNF130

1

20

High-throughput

0.698

High

1205017

DTX1
E3 ubiquitin-protein ligase DTX1

1

20

High-throughput

0.698

High

1205159

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

20

High-throughput

0.698

High

1206094

MIB1
E3 ubiquitin-protein ligase MIB1

1

10

High-throughput

0.698

High

1254722

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

20

High-throughput

0.698

High

1261313

RN138
E3 ubiquitin-protein ligase RNF138

1

20

High-throughput

0.698

High

1262545

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

20

High-throughput

0.698

High

1290127

CHFR
E3 ubiquitin-protein ligase CHFR

1

20

High-throughput

0.698

High

1290204

RN125
E3 ubiquitin-protein ligase RNF125

1

20

High-throughput

0.698

High

1291949

RMD5B
E3 ubiquitin-protein transferase RMND5B

1

6

High-throughput

0.698

High

1298970

BIRC8
Baculoviral IAP repeat-containing protein 8

1

20

High-throughput

0.698

High

1299496

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

5

High-throughput

0.698

High

1299596

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

8

High-throughput

0.698

High

1317101

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

20

High-throughput

0.698

High

1318719

TRIM5
Tripartite motif-containing protein 5

1

20

High-throughput

0.698

High

1327690

RNF38
E3 ubiquitin-protein ligase RNF38

1

20

High-throughput

0.698

High

1345306

TOPRS
E3 ubiquitin-protein ligase Topors

1

6

High-throughput

0.698

High

1346940

RNF12
E3 ubiquitin-protein ligase RLIM

1

20

High-throughput

0.698

High

1354003

RBX2
RING-box protein 2

1

20

High-throughput

0.698

High

1356934

RN150
RING finger protein 150

1

20

High-throughput

0.698

High

1357712

TRI35
E3 ubiquitin-protein ligase TRIM35

1

20

High-throughput

0.698

High

1377466

TRAF6
TNF receptor-associated factor 6

1

20

High-throughput

0.698

High

1377469

TRI17
E3 ubiquitin-protein ligase TRIM17

1

20

High-throughput

0.698

High

475249

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

20

High-throughput

0.691

High

895960

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

17

High-throughput

0.691

High

1056647

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

20

High-throughput

0.691

High

1357018

HECD1
E3 ubiquitin-protein ligase HECTD1

1

20

High-throughput

0.691

High

1316184

RNF26
E3 ubiquitin-protein ligase RNF26

1

20

High-throughput

0.656

High

1377468

RN114
E3 ubiquitin-protein ligase RNF114

1

20

High-throughput

0.656

High

1311524

UBAC1
Ubiquitin-associated domain-containing protein 1

1

0

High-throughput

0.656

High

125808

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

20

Small-scale

0.647

High

734819

TRI23
E3 ubiquitin-protein ligase TRIM23

1

17

Small-scale

0.647

High

921482

RBX1
E3 ubiquitin-protein ligase RBX1

1

20

Small-scale

0.647

High

963034

MDM2
E3 ubiquitin-protein ligase Mdm2

1

14

Small-scale

0.647

High

1264347

MYLIP
E3 ubiquitin-protein ligase MYLIP

1

4

Small-scale

0.647

High

1290106

RNF31
E3 ubiquitin-protein ligase RNF31

1

20

Small-scale

0.647

High

1294888

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

20

Small-scale

0.647

High

1357485

CHIP
E3 ubiquitin-protein ligase CHIP

1

13

Small-scale

0.647

High

1377464

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

16

Small-scale

0.647

High

1245518

ZNRF2
E3 ubiquitin-protein ligase ZNRF2

1

20

High-throughput

0.621

High

1333889

TRI45
E3 ubiquitin-protein ligase TRIM45

1

20

Small-scale

0.621

High

1354526

TRI10
Tripartite motif-containing protein 10

1

20

Small-scale

0.621

High

537142

TRI27
Zinc finger protein RFP

2

20

Small-scale

0.613

High

583844

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

1

High-throughput

0.606

High

981791

REL
Proto-oncogene c-Rel

2

6

High-throughput

0.606

High

1313765

TRI62
E3 ubiquitin-protein ligase TRIM62

2

20

High-throughput

0.606

High

1377471

NEMO
NF-kappa-B essential modulator

2

2

High-throughput

0.606

High

921784

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

3

High-throughput

0.594

High

1243628

Q8NEX1
RING-type E3 ubiquitin transferase

1

20

High-throughput

0.590

High

1065215

DAZP2
DAZ-associated protein 2

1

2

High-throughput

0.573

High

1314925

PHF7
PHD finger protein 7

1

2

High-throughput

0.573

High

1012387

INCA1
Protein INCA1

1

0

High-throughput

0.549

High

486983

MYBB
Myb-related protein B

1

2

High-throughput

0.541

High

1028455

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

12

High-throughput

0.541

High

1199325

MARH3
E3 ubiquitin-protein ligase MARCHF3

1

20

High-throughput

0.541

High

1216737

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

20

High-throughput

0.541

High

1285831

TRI43
Tripartite motif-containing protein 43

1

20

High-throughput

0.541

High

1318532

TRI31
E3 ubiquitin-protein ligase TRIM31

1

20

High-throughput

0.541

High

1349425

BFAR
Bifunctional apoptosis regulator

1

20

High-throughput

0.541

High

1254101

URGCP
Up-regulator of cell proliferation

1

1

High-throughput

0.536

High

1151762

Q6GX22
RING-type E3 ubiquitin transferase

1

20

High-throughput

0.528

High

796361

MAGAB
Melanoma-associated antigen 11

1

0

High-throughput

0.518

High

792113

HD
Huntingtin

1

1

High-throughput

0.515

High

1103595

UVSSA
UV-stimulated scaffold protein A

1

4

Small-scale

0.501

High

1347205

RN216
E3 ubiquitin-protein ligase RNF216

1

20

Small-scale

0.501

High

1200262

CAPS2
Calcium-dependent secretion activator 2

1

6

High-throughput

0.494

High

1045069

CD166
CD166 antigen

1

3

High-throughput

0.489

High

135045

TRI38
E3 ubiquitin-protein ligase TRIM38

1

20

Small-scale

0.481

High

902854

UFM1
Ubiquitin-fold modifier 1

1

5

High-throughput

0.481

High

832796

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.479

High

298910

UFL1
E3 UFM1-protein ligase 1

1

5

High-throughput

0.457

High

1204115

CARM1
Histone-arginine methyltransferase CARM1

1

1

High-throughput

0.457

High

1377470

SNURF
SNRPN upstream reading frame protein

1

3

High-throughput

0.457

High

1350261

ZNFX1
NFX1-type zinc finger-containing protein 1

1

2

High-throughput

0.417

High

296388

AL1A2
Retinal dehydrogenase 2

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024