Protein: NHLC1
E3 ubiquitin-protein ligase NHLRC1 (EC 2.3.2.27) (Malin) (NHL repeat-containing protein 1) (RING-type E3 ubiquitin transferase NHLRC1)

Gene: NHLC1, NHLRC1
Organism: Homo sapiens
Interactions: 28
UniProt ID: Q6VVB1

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

332763

EPM2A
Laforin

13

1

Small-scale

0.763

High

1250552

TRI47
E3 ubiquitin-protein ligase TRIM47

1

7

High-throughput

0.691

High

957105

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

Small-scale

0.602

High

568660

GYS1
Glycogen [starch] synthase, muscle

2

1

Small-scale

0.595

High

159712

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

7

Small-scale

0.573

High

1250555

PPR3C
Protein phosphatase 1 regulatory subunit 3C

2

0

Small-scale

0.569

High

1250554

CHIP
E3 ubiquitin-protein ligase CHIP

2

0

Small-scale

0.559

High

1250548

NHLC1
E3 ubiquitin-protein ligase NHLRC1

1

16

Small-scale

0.552

High

256635

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

2

High-throughput

0.536

High

772394

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

1

High-throughput

0.536

High

906682

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

20

Small-scale

0.501

High

909331

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

20

Small-scale

0.501

High

970679

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

Small-scale

0.501

High

461613

HS90A
Heat shock protein HSP 90-alpha

1

7

High-throughput

0.479

High

468516

HS90B
Heat shock protein HSP 90-beta

1

9

High-throughput

0.479

High

761724

HSP74
Heat shock 70 kDa protein 4

1

2

Small-scale

0.479

High

957765

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

Small-scale

0.479

High

1126709

BECN1
Beclin-1

1

1

Small-scale

0.479

High

1250550

PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

1

3

Small-scale

0.479

High

1250556

NUDC
Nuclear migration protein nudC

1

4

High-throughput

0.479

High

772615

GDE
Glycogen debranching enzyme

1

0

Small-scale

0.458

High

1250553

PRDM8
PR domain zinc finger protein 8

1

0

Small-scale

0.458

High

1245551

Q6PK50
HSP90AB1 protein

1

9

High-throughput

0.437

High

1250549

NUDC3
NudC domain-containing protein 3

1

4

High-throughput

0.437

High

1250551

Q96BE0
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.437

High

1157626

NNAT
Neuronatin

1

0

Small-scale

0.288

High

122995

KITM
Thymidine kinase 2, mitochondrial

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025