Protein: EPM2A
Laforin (EC 3.1.3.-) (EC 3.1.3.16) (EC 3.1.3.48) (Glucan phosphatase) (Glycogen phosphatase) (Lafora PTPase) (LAFPTPase)

Gene: EPM2A
Organism: Homo sapiens
Interactions: 56
UniProt ID: O95278

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0001558 - regulation of cell growth
GO:0004373 - alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity
GO:0004722 - protein serine/threonine phosphatase activity
GO:0004725 - protein tyrosine phosphatase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

332730

EPM2A
Laforin

5

0

Small-scale

0.860

High

329493

STBD1
Starch-binding domain-containing protein 1

3

0

High-throughput

0.816

High

332763

NHLC1
E3 ubiquitin-protein ligase NHLRC1

13

1

Small-scale

0.763

High

225510

AAKB2
5'-AMP-activated protein kinase subunit beta-2

2

0

Small-scale

0.752

High

332747

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

1

Small-scale

0.740

High

332744

GSK3B
Glycogen synthase kinase-3 beta

1

1

Small-scale

0.713

High

332776

PPR3C
Protein phosphatase 1 regulatory subunit 3C

4

1

Small-scale

0.683

High

332754

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

1

Small-scale

0.647

High

332731

PPR3D
Protein phosphatase 1 regulatory subunit 3D

2

1

Small-scale

0.633

High

332753

SRPK2
SRSF protein kinase 2

1

0

High-throughput

0.614

High

332768

PI3R4
Phosphoinositide 3-kinase regulatory subunit 4

1

0

Small-scale

0.586

High

332773

NFU1
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial

1

0

Small-scale

0.549

High

332736

KPYM
Pyruvate kinase PKM

1

0

Small-scale

0.529

High

332764

ANKY2
Ankyrin repeat and MYND domain-containing protein 2

1

0

High-throughput

0.517

High

332734

PYGB
Glycogen phosphorylase, brain form

1

0

High-throughput

0.513

High

332735

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.493

High

332777

SHLB1
Endophilin-B1

1

0

High-throughput

0.493

High

332737

PRS6A
26S proteasome regulatory subunit 6A

1

1

Small-scale

0.481

High

124704

AIP
AH receptor-interacting protein

1

2

High-throughput

0.479

High

273636

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

1

High-throughput

0.479

High

332732

HS74L
Heat shock 70 kDa protein 4L

1

2

High-throughput

0.479

High

332741

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.479

High

332742

HSP74
Heat shock 70 kDa protein 4

1

2

High-throughput

0.479

High

332755

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

2

High-throughput

0.479

High

332761

TOM34
Mitochondrial import receptor subunit TOM34

1

4

High-throughput

0.479

High

332774

CHIP
E3 ubiquitin-protein ligase CHIP

1

3

Small-scale

0.479

High

332775

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

1

High-throughput

0.479

High

332757

TDG
G/T mismatch-specific thymine DNA glycosylase

1

0

Small-scale

0.460

High

332758

EI2BA
Translation initiation factor eIF2B subunit alpha

1

0

Small-scale

0.460

High

332770

TOPRS
E3 ubiquitin-protein ligase Topors

1

0

Small-scale

0.460

High

332772

HMGX4
HMG domain-containing protein 4

1

0

Small-scale

0.460

High

273032

CLU
Clustered mitochondria protein homolog

1

0

High-throughput

0.458

High

324371

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

332738

PSB1
Proteasome subunit beta type-1

1

0

High-throughput

0.458

High

332740

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.458

High

332743

TCPE
T-complex protein 1 subunit epsilon

1

0

High-throughput

0.458

High

332745

PPP5
Serine/threonine-protein phosphatase 5

1

0

High-throughput

0.458

High

332746

ATX1
Ataxin-1

1

0

Small-scale

0.458

High

332748

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

High-throughput

0.458

High

332749

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

332750

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

Small-scale

0.458

High

332751

PSME3
Proteasome activator complex subunit 3

1

0

High-throughput

0.458

High

332752

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.458

High

332756

SQSTM
Sequestosome-1

1

0

Small-scale

0.458

High

332759

BECN1
Beclin-1

1

0

Small-scale

0.458

High

332760

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.458

High

332762

BRDT
Bromodomain testis-specific protein

1

0

High-throughput

0.458

High

332765

PK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3

1

0

Small-scale

0.458

High

332766

PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

1

0

Small-scale

0.458

High

332767

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.458

High

332769

MCMBP
Mini-chromosome maintenance complex-binding protein

1

0

High-throughput

0.458

High

332771

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

317962

TOM70
Mitochondrial import receptor subunit TOM70

1

3

High-throughput

0.437

High

332733

CCKN
Cholecystokinin

1

0

High-throughput

0.268

Low

332739

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

Small-scale

0.251

Low


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Last updated: 11Aug2025