Protein: PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PEPCK-C) (EC 4.1.1.32) (Serine-protein kinase PCK1) (EC 2.7.11.-)

Gene: PCKGC, PCK1
Organism: Homo sapiens
Interactions: 110
UniProt ID: P35558

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004613 - phosphoenolpyruvate carboxykinase (GTP) activity
GO:0005525 - GTP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

772390

PCKGM
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial

2

0

High-throughput

0.770

High

325705

UBR5
E3 ubiquitin-protein ligase UBR5

3

0

Small-scale

0.623

High

772384

EP300
Histone acetyltransferase p300

2

1

Small-scale

0.584

High

192457

INSI1
Insulin-induced gene 1 protein

1

1

High-throughput

0.578

High

772426

INSI2
Insulin-induced gene 2 protein

1

1

High-throughput

0.578

High

772429

NEMO
NF-kappa-B essential modulator

1

0

High-throughput

0.537

High

728064

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

High-throughput

0.536

High

772394

NHLC1
E3 ubiquitin-protein ligase NHLRC1

1

1

High-throughput

0.536

High

772401

CUL5
Cullin-5

1

1

High-throughput

0.536

High

772414

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

1

High-throughput

0.536

High

772421

ZMYM2
Zinc finger MYM-type protein 2

1

4

High-throughput

0.536

High

261109

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.513

High

287441

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.513

High

483524

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

0

High-throughput

0.513

High

702387

CYTD
Cystatin-D

1

0

High-throughput

0.513

High

732251

PRDX2
Peroxiredoxin-2

1

0

High-throughput

0.513

High

772386

DNJC3
DnaJ homolog subfamily C member 3

1

0

High-throughput

0.513

High

772393

ACKMT
ATP synthase subunit C lysine N-methyltransferase

1

0

High-throughput

0.513

High

772396

NDUAB
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

1

0

High-throughput

0.513

High

772407

MITOK
Mitochondrial potassium channel

1

0

High-throughput

0.513

High

772410

CIB3
Calcium and integrin-binding family member 3

1

0

High-throughput

0.513

High

772415

DUS15
Dual specificity protein phosphatase 15

1

0

High-throughput

0.513

High

772417

VPP4
V-type proton ATPase 116 kDa subunit a 4

1

0

High-throughput

0.513

High

772420

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

0

High-throughput

0.513

High

772424

AR2BP
ADP-ribosylation factor-like protein 2-binding protein

1

0

High-throughput

0.513

High

772428

RT18B
Small ribosomal subunit protein mS40

1

0

High-throughput

0.513

High

421604

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

155084

SOCS2
Suppressor of cytokine signaling 2

1

0

High-throughput

0.493

High

772413

MAD3
Max dimerization protein 3

1

1

High-throughput

0.489

High

772399

FBX25
F-box only protein 25

1

0

Small-scale

0.480

High

532407

CH60
60 kDa heat shock protein, mitochondrial

1

1

Small-scale

0.479

High

610550

TCPA
T-complex protein 1 subunit alpha

1

1

Small-scale

0.479

High

633612

PSB1
Proteasome subunit beta type-1

1

1

Small-scale

0.479

High

652457

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

3

Small-scale

0.479

High

681114

PSA2
Proteasome subunit alpha type-2

1

1

Small-scale

0.479

High

700564

PSA5
Proteasome subunit alpha type-5

1

1

Small-scale

0.479

High

700841

PSB4
Proteasome subunit beta type-4

1

4

Small-scale

0.479

High

772358

PRS7
26S proteasome regulatory subunit 7

1

2

Small-scale

0.479

High

772360

NUP62
Nuclear pore glycoprotein p62

1

1

Small-scale

0.479

High

772361

HNF4A
Hepatocyte nuclear factor 4-alpha

1

2

Small-scale

0.479

High

772362

PRS6B
26S proteasome regulatory subunit 6B

1

2

Small-scale

0.479

High

772364

TCPE
T-complex protein 1 subunit epsilon

1

2

Small-scale

0.479

High

772368

TCPD
T-complex protein 1 subunit delta

1

1

Small-scale

0.479

High

772369

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

Small-scale

0.479

High

772372

PRS4
26S proteasome regulatory subunit 4

1

2

Small-scale

0.479

High

772373

PRS8
26S proteasome regulatory subunit 8

1

3

Small-scale

0.479

High

772377

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

1

Small-scale

0.479

High

772378

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

1

Small-scale

0.479

High

772381

TCPB
T-complex protein 1 subunit beta

1

2

Small-scale

0.479

High

772382

GNA12
Guanine nucleotide-binding protein subunit alpha-12

1

1

Small-scale

0.479

High

772397

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

1

Small-scale

0.479

High

772411

PSB7
Proteasome subunit beta type-7

1

1

Small-scale

0.479

High

772416

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

1

Small-scale

0.479

High

772419

DDX21
Nucleolar RNA helicase 2

1

1

Small-scale

0.479

High

772423

MAGD2
Melanoma-associated antigen D2

1

1

Small-scale

0.479

High

772427

MAGD1
Melanoma-associated antigen D1

1

1

Small-scale

0.479

High

772422

ZMYM5
Zinc finger MYM-type protein 5

1

4

High-throughput

0.470

High

366120

C1R
Complement C1r subcomponent

1

0

High-throughput

0.460

High

128164

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

0

Small-scale

0.458

High

137989

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

Small-scale

0.458

High

141345

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

Small-scale

0.458

High

160432

IRS4
Insulin receptor substrate 4

1

0

Small-scale

0.458

High

173870

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

Small-scale

0.458

High

268985

ABCB7
Iron-sulfur clusters transporter ABCB7, mitochondrial

1

0

Small-scale

0.458

High

358627

LDHA
L-lactate dehydrogenase A chain

1

0

Small-scale

0.458

High

428626

RLA0
Large ribosomal subunit protein uL10

1

0

Small-scale

0.458

High

507608

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

Small-scale

0.458

High

520764

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

0

Small-scale

0.458

High

555910

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

623150

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.458

High

658002

RS3
Small ribosomal subunit protein uS3

1

0

Small-scale

0.458

High

690782

1433T
14-3-3 protein theta

1

0

Small-scale

0.458

High

727700

DNJA1
DnaJ homolog subfamily A member 1

1

0

Small-scale

0.458

High

761335

HS71L
Heat shock 70 kDa protein 1-like

1

0

Small-scale

0.458

High

772357

BASI
Basigin

1

0

Small-scale

0.458

High

772359

RL4
Large ribosomal subunit protein uL4

1

0

Small-scale

0.458

High

772363

BAG6
Large proline-rich protein BAG6

1

0

Small-scale

0.458

High

772365

FAS
Fatty acid synthase

1

0

Small-scale

0.458

High

772366

CPT1A
Carnitine O-palmitoyltransferase 1, liver isoform

1

0

Small-scale

0.458

High

772367

RL14
Large ribosomal subunit protein eL14

1

0

Small-scale

0.458

High

772370

ACTB
Actin, cytoplasmic 1

1

0

Small-scale

0.458

High

772371

RS3A
Small ribosomal subunit protein eS1

1

0

Small-scale

0.458

High

772374

RS15A
Small ribosomal subunit protein uS8

1

0

Small-scale

0.458

High

772375

RS6
Small ribosomal subunit protein eS6

1

0

Small-scale

0.458

High

772376

RL23
Large ribosomal subunit protein uL14

1

0

Small-scale

0.458

High

772379

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.458

High

772380

UBC9
SUMO-conjugating enzyme UBC9

1

0

Small-scale

0.458

High

772383

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

Small-scale

0.458

High

772385

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

Small-scale

0.458

High

772387

SQSTM
Sequestosome-1

1

0

Small-scale

0.458

High

772388

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

0

Small-scale

0.458

High

772389

ELOC
Elongin-C

1

0

Small-scale

0.458

High

772395

GGYF2
GRB10-interacting GYF protein 2

1

0

Small-scale

0.458

High

772398

PCAT1
Lysophosphatidylcholine acyltransferase 1

1

0

Small-scale

0.458

High

772405

FAF2
FAS-associated factor 2

1

0

Small-scale

0.458

High

772409

RL10L
Ribosomal protein uL16-like

1

0

Small-scale

0.458

High

772412

T22D3
TSC22 domain family protein 3

1

0

Small-scale

0.458

High

772418

GEPH
Gephyrin [Includes: Molybdopterin adenylyltransferase

1

0

Small-scale

0.458

High

772425

SRPRB
Signal recognition particle receptor subunit beta

1

0

Small-scale

0.458

High

178726

SCAM1
Secretory carrier-associated membrane protein 1

1

0

High-throughput

0.279

Low

229263

ANGL7
Angiopoietin-related protein 7

1

0

High-throughput

0.279

Low

376595

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

0

High-throughput

0.279

Low

772392

SPAT1
Spermatogenesis-associated protein 1

1

0

High-throughput

0.279

Low

772400

DCNL4
DCN1-like protein 4

1

0

High-throughput

0.279

Low

772402

SNX21
Sorting nexin-21

1

0

High-throughput

0.279

Low

772403

ZDH16
Palmitoyltransferase ZDHHC16

1

0

High-throughput

0.279

Low

772404

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.279

Low

772406

ZN501
Zinc finger protein 501

1

0

High-throughput

0.279

Low

772408

MYEOV
Myeloma-overexpressed gene protein

1

0

High-throughput

0.279

Low

772391

Z585B
Zinc finger protein 585B

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025