Protein: GDE
Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)]

Gene: GDE, AGL
Organism: Homo sapiens
Interactions: 73
UniProt ID: P35573

Gene Ontology (top 5):
GO:0004134 - 4-alpha-glucanotransferase activity
GO:0004135 - amylo-alpha-1,6-glucosidase activity
GO:0005576 - extracellular region
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

329517

STBD1
Starch-binding domain-containing protein 1

2

0

High-throughput

0.602

High

192009

GLYG2
Glycogenin-2

1

1

High-throughput

0.536

High

692008

MARK3
MAP/microtubule affinity-regulating kinase 3

1

1

High-throughput

0.536

High

772597

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

1

High-throughput

0.536

High

772605

CUL1
Cullin-1

1

4

High-throughput

0.536

High

772606

CUL2
Cullin-2

1

4

High-throughput

0.536

High

772607

CUL3
Cullin-3

1

4

High-throughput

0.536

High

772608

CUL4B
Cullin-4B

1

4

High-throughput

0.536

High

772624

CUL5
Cullin-5

1

4

High-throughput

0.536

High

772636

DP13A
DCC-interacting protein 13-alpha

1

0

High-throughput

0.518

High

225542

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

0

High-throughput

0.513

High

539521

PYGB
Glycogen phosphorylase, brain form

1

0

High-throughput

0.513

High

585765

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

0

High-throughput

0.513

High

772596

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

0

High-throughput

0.513

High

772603

CDK5
Cyclin-dependent kinase 5

1

0

High-throughput

0.513

High

772620

RASF5
Ras association domain-containing protein 5

1

0

High-throughput

0.513

High

772623

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

772626

AURKB
Aurora kinase B

1

0

High-throughput

0.513

High

772627

DCNL1
DCN1-like protein 1

1

0

High-throughput

0.513

High

772638

FOXA2
Hepatocyte nuclear factor 3-beta

1

0

High-throughput

0.513

High

335309

M3K6
Mitogen-activated protein kinase kinase kinase 6

1

1

High-throughput

0.489

High

240907

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

335019

ARI2
E3 ubiquitin-protein ligase ARIH2

1

1

High-throughput

0.479

High

772604

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

772612

LARP7
La-related protein 7

1

2

High-throughput

0.479

High

772621

ASB15
Ankyrin repeat and SOCS box protein 15

1

1

High-throughput

0.479

High

772637

TRI33
E3 ubiquitin-protein ligase TRIM33

1

1

High-throughput

0.479

High

772640

ASB3
Ankyrin repeat and SOCS box protein 3

1

1

High-throughput

0.479

High

142867

NFIB
Nuclear factor 1 B-type

1

0

High-throughput

0.458

High

316768

MTA2
Metastasis-associated protein MTA2

1

0

High-throughput

0.458

High

324594

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

336882

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

Small-scale

0.458

High

400387

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

529215

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.458

High

536620

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

588048

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

599552

STMN1
Stathmin

1

0

High-throughput

0.458

High

612898

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

613309

VINC
Vinculin

1

0

High-throughput

0.458

High

694762

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

772594

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

772595

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

772599

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

772602

VIGLN
Vigilin

1

0

High-throughput

0.458

High

772610

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

772611

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

772613

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

772614

TENS2
Tensin-2

1

0

High-throughput

0.458

High

772615

NHLC1
E3 ubiquitin-protein ligase NHLRC1

1

0

Small-scale

0.458

High

772616

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

772617

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

772622

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

772625

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

772628

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

772629

RN126
E3 ubiquitin-protein ligase RNF126

1

0

High-throughput

0.458

High

772634

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

772598

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

1

High-throughput

0.445

High

772633

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

1

High-throughput

0.445

High

404706

PRIO
Major prion protein

1

0

High-throughput

0.426

High

442617

RB
Retinoblastoma-associated protein

1

0

High-throughput

0.426

High

772600

CBX1
Chromobox protein homolog 1

1

0

Small-scale

0.426

High

772601

SMAD3
Mothers against decapentaplegic homolog 3

1

0

Small-scale

0.426

High

772635

UVRAG
UV radiation resistance-associated gene protein

1

0

High-throughput

0.426

High

772639

SHLB1
Endophilin-B1

1

0

High-throughput

0.426

High

105456

APRIO
Alternative prion protein

2

0

High-throughput

0.305

High

772609

FASTK
Fas-activated serine/threonine kinase

1

0

High-throughput

0.279

Low

411473

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

767543

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

772618

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.249

Low

772619

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

772630

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.249

Low

772632

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

Small-scale

0.249

Low

772631

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025