Protein: IC1
Plasma protease C1 inhibitor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor) (Serpin G1)

Gene: IC1, SERPING1
Organism: Homo sapiens
Interactions: 42
UniProt ID: P05155

Gene Ontology (top 5):
GO:0001869 - negative regulation of complement activation, lectin pathway
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005788 - endoplasmic reticulum lumen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

366517

TPA
Tissue-type plasminogen activator

2

20

High-throughput

0.811

High

425210

C1S
Complement C1s subcomponent

2

20

Small-scale

0.737

High

132984

MATN2
Matrilin-2

1

3

High-throughput

0.691

High

210679

KLK10
Kallikrein-10

1

20

High-throughput

0.691

High

125801

MASP2
Mannan-binding lectin serine protease 2

1

20

Small-scale

0.647

High

366085

THRB
Prothrombin

1

20

Small-scale

0.647

High

425209

ELNE
Neutrophil elastase

1

20

Small-scale

0.647

High

425219

MASP1
Mannan-binding lectin serine protease 1

1

20

Small-scale

0.647

High

369233

ANT3
Antithrombin-III

1

12

High-throughput

0.618

High

425223

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

2

3

High-throughput

0.574

High

389923

ALBU
Albumin

1

3

High-throughput

0.536

High

425211

BIP
Endoplasmic reticulum chaperone BiP

1

13

High-throughput

0.536

High

425231

EGFL8
Epidermal growth factor-like protein 8

1

4

High-throughput

0.536

High

425213

LYAM3
P-selectin

1

4

Small-scale

0.515

High

425214

LYAM2
E-selectin

1

3

Small-scale

0.515

High

425216

GRN
Progranulin

1

0

High-throughput

0.513

High

425208

HS90A
Heat shock protein HSP 90-alpha

1

5

Small-scale

0.501

High

425220

SRPK2
SRSF protein kinase 2

1

5

High-throughput

0.501

High

425217

CCR1
C-C chemokine receptor type 1

1

9

High-throughput

0.489

High

425224

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

8

High-throughput

0.489

High

425225

SE1L3
Protein sel-1 homolog 3

1

1

High-throughput

0.489

High

425226

CIR1
Corepressor interacting with RBPJ 1

1

2

High-throughput

0.489

High

425227

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

1

3

High-throughput

0.489

High

425229

RHBL4
Rhomboid-related protein 4

1

5

High-throughput

0.489

High

425230

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

10

High-throughput

0.489

High

425233

PHF11
PHD finger protein 11

1

9

High-throughput

0.489

High

425234

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

4

High-throughput

0.489

High

425236

ING4
Inhibitor of growth protein 4

1

1

High-throughput

0.489

High

425218

BAG6
Large proline-rich protein BAG6

1

8

High-throughput

0.481

High

125142

LEG9
Galectin-9

1

5

Small-scale

0.479

High

369805

CO3
Complement C3

1

1

High-throughput

0.479

High

405592

HRG
Histidine-rich glycoprotein

1

2

High-throughput

0.479

High

425222

ITIH4
Inter-alpha-trypsin inhibitor heavy chain H4

1

2

High-throughput

0.479

High

230239

CREB3
Cyclic AMP-responsive element-binding protein 3

1

1

High-throughput

0.470

High

425207

ENOA
Alpha-enolase

1

0

High-throughput

0.460

High

425221

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

3

Small-scale

0.445

High

425212

CFTR
Cystic fibrosis transmembrane conductance regulator

1

9

High-throughput

0.439

High

425215

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

9

High-throughput

0.439

High

425232

ZNT2
Proton-coupled zinc antiporter SLC30A2

1

1

High-throughput

0.439

High

105115

APRIO
Alternative prion protein

1

6

High-throughput

0.437

High

425235

FBX2
F-box only protein 2

1

7

High-throughput

0.407

High

425228

ARFG2
ADP-ribosylation factor GTPase-activating protein 2

2

0

High-throughput

0.328

High


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Last updated: 11Aug2025