Interactor 1: MASP2 (O00187)
Mannan-binding lectin serine protease 2 (EC 3.4.21.104) (MBL-associated serine protease 2) (Mannose-binding protein-associated serine protease 2) (MASP-2) [Cleaved into: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain]
Gene: MASP2
Interactor 2: CO2 (P06681)
Complement C2 (C3/C5 convertase) [Cleaved into: Complement C2a; Serine protease complement C2b (EC 3.4.21.43)]
Gene: C2
Species: Homo sapiens
Source: innatedb
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.33 | 1.00 | 0.575 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 11527969 |
| Identification Methods | protease assay |
| Interaction Type | cleavage reaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | CUB~Sushi, CUB~Trypsin, EGF_CA~Sushi, Sushi~Sushi, Sushi~Trypsin, Sushi~VWA, Trypsin~Trypsin, Trypsin~VWA |
| Common GO terms | GO:0004252 - serine-type endopeptidase activity GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0006508 - proteolysis GO:0006958 - complement activation, classical pathway and 1 others more... |
| Homologous interactions | 17 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
