Protein: HNF1A
Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1)

Gene: HNF1A
Organism: Homo sapiens
Interactions: 85
UniProt ID: P20823

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

635169

HNF1B
Hepatocyte nuclear factor 1-beta

5

13

Small-scale

0.713

High

635217

PHS2
Pterin-4-alpha-carbinolamine dehydratase 2

4

6

Small-scale

0.694

High

635185

EP300
Histone acetyltransferase p300

3

10

Small-scale

0.664

High

635177

PHS
Pterin-4-alpha-carbinolamine dehydratase

5

6

Small-scale

0.659

High

635164

HNF1A
Hepatocyte nuclear factor 1-alpha

3

5

Small-scale

0.656

High

635208

CBP
CREB-binding protein

2

9

Small-scale

0.624

High

635226

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

2

1

Small-scale

0.619

High

635222

RNF14
E3 ubiquitin-protein ligase RNF14

1

0

Small-scale

0.568

High

635190

NCOA1
Nuclear receptor coactivator 1

1

3

Small-scale

0.561

High

635209

KAT2B
Histone acetyltransferase KAT2B

1

5

Small-scale

0.561

High

635210

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

1

Small-scale

0.561

High

635228

NCOA3
Nuclear receptor coactivator 3

1

5

Small-scale

0.561

High

343893

HS74L
Heat shock 70 kDa protein 4L

1

2

High-throughput

0.536

High

635168

HSP74
Heat shock 70 kDa protein 4

1

2

High-throughput

0.536

High

481088

HMGB1
High mobility group protein B1

1

8

Small-scale

0.534

High

635167

1433B
14-3-3 protein beta/alpha

1

3

Small-scale

0.515

High

635178

1433G
14-3-3 protein gamma

1

3

Small-scale

0.515

High

635181

1433Z
14-3-3 protein zeta/delta

1

3

Small-scale

0.515

High

635186

CBX3
Chromobox protein homolog 3

1

1

Small-scale

0.515

High

635171

BCL6
B-cell lymphoma 6 protein

1

0

Small-scale

0.513

High

635213

CDX2
Homeobox protein CDX-2

1

3

Small-scale

0.501

High

635183

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.500

High

635206

HS105
Heat shock protein 105 kDa

1

2

High-throughput

0.500

High

358609

LDHA
L-lactate dehydrogenase A chain

1

0

Small-scale

0.493

High

456606

ANXA2
Annexin A2

1

0

Small-scale

0.493

High

474474

VIME
Vimentin

1

0

Small-scale

0.493

High

485564

RU2A
U2 small nuclear ribonucleoprotein A'

1

0

High-throughput

0.493

High

563184

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

Small-scale

0.493

High

635166

PEBP1
Phosphatidylethanolamine-binding protein 1

1

0

Small-scale

0.493

High

635172

RANG
Ran-specific GTPase-activating protein

1

0

Small-scale

0.493

High

635175

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.493

High

635176

ACTB
Actin, cytoplasmic 1

1

0

Small-scale

0.493

High

635179

1433E
14-3-3 protein epsilon

1

0

Small-scale

0.493

High

635192

SRSF7
Serine/arginine-rich splicing factor 7

1

0

Small-scale

0.493

High

635202

H2A2B
Histone H2A type 2-B

1

0

Small-scale

0.493

High

635207

PROX1
Prospero homeobox protein 1

1

0

Small-scale

0.493

High

635187

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.484

High

635184

TLE5
TLE family member 5

1

3

Small-scale

0.481

High

581753

MYOG
Myogenin

1

0

Small-scale

0.480

High

137526

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

2

Small-scale

0.479

High

161407

KMT2D
Histone-lysine N-methyltransferase 2D

1

4

High-throughput

0.479

High

194508

KDM6A
Lysine-specific demethylase 6A

1

1

High-throughput

0.479

High

505513

ATX1L
Ataxin-1-like

1

2

High-throughput

0.479

High

609861

IBP3
Insulin-like growth factor-binding protein 3

1

1

Small-scale

0.479

High

635170

STAT3
Signal transducer and activator of transcription 3

1

1

Small-scale

0.479

High

635174

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

3

Small-scale

0.479

High

635194

LIN9
Protein lin-9 homolog

1

1

High-throughput

0.479

High

635195

ZMYM4
Zinc finger MYM-type protein 4

1

3

High-throughput

0.479

High

635197

MCAF1
Activating transcription factor 7-interacting protein 1

1

7

High-throughput

0.479

High

635198

BCOR
BCL-6 corepressor

1

1

High-throughput

0.479

High

635199

PAXI1
PAX-interacting protein 1

1

5

High-throughput

0.479

High

635200

POGZ
Pogo transposable element with ZNF domain

1

1

High-throughput

0.479

High

635203

KMT2C
Histone-lysine N-methyltransferase 2C

1

7

High-throughput

0.479

High

635204

KDM2B
Lysine-specific demethylase 2B

1

1

High-throughput

0.479

High

635212

CIC
Protein capicua homolog

1

11

High-throughput

0.479

High

635214

ARI3A
AT-rich interactive domain-containing protein 3A

1

7

High-throughput

0.479

High

635216

SP130
Histone deacetylase complex subunit SAP130

1

7

High-throughput

0.479

High

635218

SEBOX
Homeobox protein SEBOX

1

3

Small-scale

0.479

High

635220

TF7L2
Transcription factor 7-like 2

1

12

High-throughput

0.479

High

370560

FOS
Protein c-Fos

1

0

Small-scale

0.458

High

601559

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

Small-scale

0.458

High

635180

RAN
GTP-binding nuclear protein Ran

1

0

High-throughput

0.458

High

635182

FABP5
Fatty acid-binding protein 5

1

0

High-throughput

0.458

High

635193

TCAL5
Transcription elongation factor A protein-like 5

1

0

High-throughput

0.458

High

635196

Q6FGD7
Tubulin-specific chaperone A

1

0

High-throughput

0.458

High

635211

ZBED3
Zinc finger BED domain-containing protein 3

1

0

Small-scale

0.458

High

635224

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

635225

NPCL1
NPC1-like intracellular cholesterol transporter 1

1

0

Small-scale

0.458

High

476427

IBP1
Insulin-like growth factor-binding protein 1

1

2

Small-scale

0.437

High

635189

RYR3
Ryanodine receptor 3

1

0

High-throughput

0.292

High

635215

WN10A
Protein Wnt-10a

1

0

High-throughput

0.279

Low

635191

IBP7
Insulin-like growth factor-binding protein 7

1

0

Small-scale

0.269

Low

635201

RHPN2
Rhophilin-2

1

0

High-throughput

0.269

Low

635227

SNX14
Sorting nexin-14

1

0

Small-scale

0.269

Low

211674

LEU1
Leukemia-associated protein 1

1

0

Small-scale

0.249

Low

357910

CYB5
Cytochrome b5

1

0

Small-scale

0.249

Low

369311

A1AT
Alpha-1-antitrypsin

1

0

Small-scale

0.249

Low

635165

ADH6
Alcohol dehydrogenase 6

1

0

Small-scale

0.249

Low

635173

T4S4
Transmembrane 4 L6 family member 4

1

0

Small-scale

0.249

Low

635188

HABP2
Factor VII-activating protease

1

0

Small-scale

0.249

Low

635205

ASM3A
Cyclic GMP-AMP phosphodiesterase SMPDL3A

1

0

High-throughput

0.249

Low

635219

SGK2
Serine/threonine-protein kinase Sgk2

1

0

Small-scale

0.249

Low

635221

RM15
Large ribosomal subunit protein uL15m

1

0

Small-scale

0.249

Low

635223

SE1L1
Protein sel-1 homolog 1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025