Protein: DHB7
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (17-beta-hydroxysteroid dehydrogenase 7) (17-beta-HSD 7) (3-keto-steroid reductase) (EC 1.1.1.270) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Estradiol 17-beta-dehydrogenase 7) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 37C member 1)

Gene: DHB7, HSD17B7
Organism: Homo sapiens
Interactions: 50
UniProt ID: P56937

Gene Ontology (top 5):
GO:0000253 - 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity
GO:0004303 - estradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO:0005739 - mitochondrion
GO:0005789 - endoplasmic reticulum membrane
GO:0006695 - cholesterol biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

942488

SLAF1
Signaling lymphocytic activation molecule

3

3

High-throughput

0.609

High

942501

SPX3
Sugar phosphate exchanger 3

2

2

High-throughput

0.601

High

845000

EAA3
Excitatory amino acid transporter 3

2

4

High-throughput

0.552

High

942484

LCN6
Epididymal-specific lipocalin-6

2

1

High-throughput

0.549

High

942486

VMAT2
Synaptic vesicular amine transporter

2

2

High-throughput

0.549

High

942499

GPAT4
Glycerol-3-phosphate acyltransferase 4

1

2

High-throughput

0.541

High

926753

VMAT1
Chromaffin granule amine transporter

1

7

High-throughput

0.536

High

942510

S22A4
Solute carrier family 22 member 4

1

4

High-throughput

0.536

High

663353

KTHY
Thymidylate kinase

1

0

High-throughput

0.518

High

367550

CAH1
Carbonic anhydrase 1

1

1

High-throughput

0.494

High

942504

BRSK1
Serine/threonine-protein kinase BRSK1

1

3

High-throughput

0.494

High

133235

P2Y10
Putative P2Y purinoceptor 10

1

6

High-throughput

0.489

High

380273

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

3

High-throughput

0.489

High

848468

MAGA8
Melanoma-associated antigen 8

1

3

High-throughput

0.489

High

942491

AAAT
Neutral amino acid transporter B(0)

1

4

High-throughput

0.489

High

942494

S39AC
Zinc transporter ZIP12

1

6

High-throughput

0.489

High

942498

SV2A
Synaptic vesicle glycoprotein 2A

1

5

High-throughput

0.489

High

942489

ACOX1
Peroxisomal acyl-coenzyme A oxidase 1

1

6

High-throughput

0.470

High

942509

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

Small-scale

0.460

High

437655

HEPS
Serine protease hepsin

1

1

High-throughput

0.445

High

942485

ACVR1
Activin receptor type-1

1

2

High-throughput

0.445

High

942511

ZDH11
Palmitoyltransferase ZDHHC11

1

2

High-throughput

0.445

High

293444

CD123
Translation initiation factor eIF2 assembly protein

1

5

High-throughput

0.437

High

588333

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

695062

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

942487

TIF1B
Transcription intermediary factor 1-beta

1

3

High-throughput

0.437

High

942490

RYR3
Ryanodine receptor 3

1

4

High-throughput

0.437

High

942497

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

942512

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.437

High

942493

DOXA2
Dual oxidase maturation factor 2

1

0

High-throughput

0.426

High

248857

GSDME
Gasdermin-E

1

1

High-throughput

0.407

High

260851

RAMP3
Receptor activity-modifying protein 3

1

2

High-throughput

0.407

High

379496

IGHM
Immunoglobulin heavy constant mu

1

4

High-throughput

0.407

High

388614

C1QA
Complement C1q subcomponent subunit A

1

1

High-throughput

0.407

High

844916

EAA2
Excitatory amino acid transporter 2

1

4

High-throughput

0.407

High

935711

MFAP4
Microfibril-associated glycoprotein 4

1

1

High-throughput

0.407

High

942500

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

5

High-throughput

0.407

High

942503

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

1

1

High-throughput

0.407

High

942507

LPAR1
Lysophosphatidic acid receptor 1

1

2

High-throughput

0.407

High

942513

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

2

High-throughput

0.407

High

446516

DPOLB
DNA polymerase beta

3

0

High-throughput

0.347

High

567207

PPA5
Tartrate-resistant acid phosphatase type 5

3

0

High-throughput

0.347

High

942496

GORAB
RAB6-interacting golgin

1

0

High-throughput

0.282

High

942495

TFDP3
Transcription factor Dp family member 3

1

0

High-throughput

0.279

Low

942505

DDI1
Protein DDI1 homolog 1

1

0

High-throughput

0.279

Low

942506

GLMP
Glycosylated lysosomal membrane protein

1

0

High-throughput

0.279

Low

942508

ORAI1
Calcium release-activated calcium channel protein 1

1

0

High-throughput

0.279

Low

942492

E2F4
Transcription factor E2F4

1

0

High-throughput

0.249

Low

342530

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.232

Low

942502

F174A
Membrane protein FAM174A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025