Protein: RN181
E3 ubiquitin-protein ligase RNF181 (EC 2.3.2.27) (RING finger protein 181)

Gene: RN181, RNF181
Organism: Homo sapiens
Interactions: 140
UniProt ID: Q9P0P0

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005737 - cytoplasm
GO:0008270 - zinc ion binding
GO:0016567 - protein ubiquitination
GO:0051865 - protein autoubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

906804

UB2D1
Ubiquitin-conjugating enzyme E2 D1

5

20

Small-scale

0.925

High

1453960

UB2D4
Ubiquitin-conjugating enzyme E2 D4

3

20

High-throughput

0.861

High

982345

UB2D2
Ubiquitin-conjugating enzyme E2 D2

3

20

Small-scale

0.857

High

909402

UB2E1
Ubiquitin-conjugating enzyme E2 E1

2

20

Small-scale

0.800

High

957221

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

Small-scale

0.800

High

507398

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

20

Small-scale

0.713

High

987250

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

14

Small-scale

0.713

High

1381212

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

High-throughput

0.698

High

1398310

RN145
RING finger protein 145

1

11

High-throughput

0.691

High

508748

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

Small-scale

0.647

High

957855

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

Small-scale

0.647

High

1453954

RN181
E3 ubiquitin-protein ligase RNF181

1

12

Small-scale

0.647

High

887599

PSB3
Proteasome subunit beta type-3

2

7

High-throughput

0.628

High

1218766

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.625

High

1294581

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

11

High-throughput

0.618

High

700544

PSB9
Proteasome subunit beta type-9

3

7

High-throughput

0.609

High

733862

CDD
Cytidine deaminase

2

0

High-throughput

0.602

High

1453963

FBX7
F-box only protein 7

2

0

High-throughput

0.602

High

397103

ESR1
Estrogen receptor

2

7

Small-scale

0.584

High

470431

ITA2B
Integrin alpha-IIb

2

1

Small-scale

0.575

High

1336043

CTL5
Choline transporter-like protein 5

2

1

High-throughput

0.574

High

1417018

CAR11
Caspase recruitment domain-containing protein 11

1

2

Small-scale

0.561

High

391717

MT2
Metallothionein-2

1

2

Small-scale

0.552

High

1292242

LONP2
Lon protease homolog 2, peroxisomal

2

3

High-throughput

0.549

High

180949

TIF1A
Transcription intermediary factor 1-alpha

1

5

High-throughput

0.541

High

1107496

BIRC2
Baculoviral IAP repeat-containing protein 2

1

5

High-throughput

0.541

High

1287224

PEG10
Retrotransposon-derived protein PEG10

1

1

High-throughput

0.541

High

1418822

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

2

High-throughput

0.541

High

1420188

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

6

High-throughput

0.541

High

163179

CHK1
Serine/threonine-protein kinase Chk1

1

2

High-throughput

0.536

High

165424

PSA7
Proteasome subunit alpha type-7

1

5

High-throughput

0.536

High

276352

HMMR
Hyaluronan mediated motility receptor

1

5

High-throughput

0.536

High

334258

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

1

High-throughput

0.536

High

1199896

AKIR2
Akirin-2

1

1

High-throughput

0.536

High

1337788

TRPV3
Transient receptor potential cation channel subfamily V member 3

1

1

High-throughput

0.536

High

1418010

GNB1L
Guanine nucleotide-binding protein subunit beta-like protein 1

1

3

High-throughput

0.536

High

1448375

PICK1
PRKCA-binding protein

1

1

High-throughput

0.536

High

1453964

KIF3A
Kinesin-like protein KIF3A

1

1

High-throughput

0.536

High

294637

ZMY10
Zinc finger MYND domain-containing protein 10

1

0

High-throughput

0.518

High

974907

BTG1
Protein BTG1

1

0

High-throughput

0.518

High

1431599

VPS11
Vacuolar protein sorting-associated protein 11 homolog

1

0

High-throughput

0.518

High

320841

KLH18
Kelch-like protein 18

1

0

High-throughput

0.513

High

339185

TYDP2
Tyrosyl-DNA phosphodiesterase 2

1

0

High-throughput

0.513

High

691864

MK03
Mitogen-activated protein kinase 3

1

0

High-throughput

0.513

High

1050373

ICA69
Islet cell autoantigen 1

1

0

High-throughput

0.513

High

1064188

ADCY2
Adenylate cyclase type 2

1

0

High-throughput

0.513

High

1271336

MON1B
Vacuolar fusion protein MON1 homolog B

1

0

High-throughput

0.513

High

1387040

NMD3
60S ribosomal export protein NMD3

1

0

High-throughput

0.513

High

1453959

MTMR6
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6

1

0

High-throughput

0.513

High

1153386

NPY5R
Neuropeptide Y receptor type 5

1

1

High-throughput

0.494

High

1437867

CLK4
Dual specificity protein kinase CLK4

1

3

High-throughput

0.494

High

325226

OR6B1
Olfactory receptor 6B1

1

1

High-throughput

0.489

High

954753

SEM1
26S proteasome complex subunit SEM1

1

1

Small-scale

0.489

High

1208384

WIPI3
WD repeat domain phosphoinositide-interacting protein 3

1

5

High-throughput

0.489

High

1334332

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

1

2

High-throughput

0.489

High

1340001

OR5M3
Olfactory receptor 5M3

1

1

High-throughput

0.489

High

1340002

OR5M8
Olfactory receptor 5M8

1

1

High-throughput

0.489

High

1358676

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

1

3

High-throughput

0.489

High

1391991

TRM2B
tRNA

1

1

High-throughput

0.489

High

1437174

AKIR1
Akirin-1

1

1

High-throughput

0.489

High

1453955

TM63C
Osmosensitive cation channel TMEM63C

1

1

High-throughput

0.489

High

1453956

NAGK
N-acetyl-D-glucosamine kinase

1

2

High-throughput

0.489

High

390201

ALBU
Albumin

1

2

Small-scale

0.481

High

415124

MT1E
Metallothionein-1E

1

2

Small-scale

0.481

High

1009817

MT1H
Metallothionein-1H

1

2

Small-scale

0.481

High

353906

BCL10
B-cell lymphoma/leukemia 10

1

0

Small-scale

0.480

High

331377

KI20A
Kinesin-like protein KIF20A

1

2

High-throughput

0.479

High

837263

ACTY
Beta-centractin

1

3

High-throughput

0.479

High

887732

PSB2
Proteasome subunit beta type-2

1

8

Small-scale

0.479

High

934184

XPO2
Exportin-2

1

2

High-throughput

0.479

High

958529

ACTZ
Alpha-centractin

1

3

High-throughput

0.479

High

972981

RS18
Small ribosomal subunit protein uS13

1

1

High-throughput

0.479

High

975999

RL7A
Large ribosomal subunit protein eL8

1

2

High-throughput

0.479

High

993005

RACK1
Small ribosomal subunit protein RACK1

1

5

High-throughput

0.479

High

1110749

DCTN2
Dynactin subunit 2

1

1

High-throughput

0.479

High

1123846

DCTN1
Dynactin subunit 1

1

5

High-throughput

0.479

High

1139691

SYK
Lysine--tRNA ligase

1

1

High-throughput

0.479

High

1203628

ZN326
DBIRD complex subunit ZNF326

1

1

High-throughput

0.479

High

1277795

MYH14
Myosin-14

1

5

High-throughput

0.479

High

1368906

RBP56
TATA-binding protein-associated factor 2N

1

4

High-throughput

0.479

High

1406077

PHB2
Prohibitin-2

1

1

High-throughput

0.479

High

1453962

RTCB
RNA-splicing ligase RtcB homolog

1

1

High-throughput

0.479

High

1250704

GDPD4
Glycerophosphodiester phosphodiesterase domain-containing protein 4

1

1

High-throughput

0.470

High

1326604

CTL3
Choline transporter-like protein 3

1

1

High-throughput

0.470

High

859485

RL5
Large ribosomal subunit protein uL18

1

0

Small-scale

0.460

High

567505

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

612000

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.458

High

630069

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

1059986

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

0

High-throughput

0.458

High

1212869

UBR4
E3 ubiquitin-protein ligase UBR4

1

0

High-throughput

0.458

High

1453958

DCTN4
Dynactin subunit 4

1

0

High-throughput

0.458

High

137344

ELL2
RNA polymerase II elongation factor ELL2

1

2

Small-scale

0.439

High

387910

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

1

Small-scale

0.439

High

756384

MCM7
DNA replication licensing factor MCM7

1

2

Small-scale

0.439

High

999695

HBA
Hemoglobin subunit alpha

1

3

Small-scale

0.439

High

171774

GAK
Cyclin-G-associated kinase

1

4

High-throughput

0.437

High

211066

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

2

High-throughput

0.437

High

224380

BUB3
Mitotic checkpoint protein BUB3

1

3

High-throughput

0.437

High

447879

TPM3
Tropomyosin alpha-3 chain

1

4

High-throughput

0.437

High

482970

TPM1
Tropomyosin alpha-1 chain

1

4

High-throughput

0.437

High

483976

HMOX1
Heme oxygenase 1

1

1

Small-scale

0.437

High

542259

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.437

High

573705

ENPL
Endoplasmin

1

4

High-throughput

0.437

High

595899

H13
Histone H1.3

1

2

High-throughput

0.437

High

610921

TCPA
T-complex protein 1 subunit alpha

1

4

High-throughput

0.437

High

690593

PON1
Serum paraoxonase/arylesterase 1

1

1

High-throughput

0.437

High

870001

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

1

High-throughput

0.437

High

882198

TCPG
T-complex protein 1 subunit gamma

1

6

High-throughput

0.437

High

899613

TCPD
T-complex protein 1 subunit delta

1

4

High-throughput

0.437

High

952659

MYL6
Myosin light polypeptide 6

1

5

High-throughput

0.437

High

995495

TPM4
Tropomyosin alpha-4 chain

1

4

High-throughput

0.437

High

1193397

GLYR1
Cytokine-like nuclear factor N-PAC

1

2

High-throughput

0.437

High

1452948

ARP10
Actin-related protein 10

1

2

High-throughput

0.437

High

1453965

UTP18
U3 small nucleolar RNA-associated protein 18 homolog

1

1

High-throughput

0.437

High

389890

TTHY
Transthyretin

1

1

High-throughput

0.407

High

1289839

PAQR2
Adiponectin receptor protein 2

3

0

High-throughput

0.347

High

248634

FADS1
Acyl-CoA

2

0

High-throughput

0.328

High

1434561

VIAAT
Vesicular inhibitory amino acid transporter

2

0

High-throughput

0.328

High

1411076

PIGQ
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q

2

0

High-throughput

0.313

High

1012782

RT06
Small ribosomal subunit protein bS6m

1

0

High-throughput

0.282

High

230211

S28A2
Sodium/nucleoside cotransporter 2

1

0

High-throughput

0.279

Low

336581

PIGN
GPI ethanolamine phosphate transferase 1

1

0

High-throughput

0.279

Low

947879

T2R38
Taste receptor type 2 member 38

1

0

High-throughput

0.279

Low

1017817

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.279

Low

1108499

TRPC3
Short transient receptor potential channel 3

1

0

High-throughput

0.279

Low

1251847

PPR21
Protein phosphatase 1 regulatory subunit 21

1

0

High-throughput

0.279

Low

1333616

SIDT2
SID1 transmembrane family member 2

1

0

High-throughput

0.279

Low

1387680

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

1417771

PECR
Peroxisomal trans-2-enoyl-CoA reductase

1

0

High-throughput

0.279

Low

1434824

NSUN3
tRNA

1

0

High-throughput

0.279

Low

1453957

TSR3
18S rRNA aminocarboxypropyltransferase

1

0

High-throughput

0.279

Low

1453961

ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial

1

0

High-throughput

0.279

Low

1230848

SL9A4
Sodium/hydrogen exchanger 4

1

0

High-throughput

0.269

Low

353997

NDUBA
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

1

0

Small-scale

0.251

Low

298241

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.249

Low

873341

COPD
Coatomer subunit delta

1

0

High-throughput

0.249

Low

973835

RUXE
Small nuclear ribonucleoprotein E

1

0

High-throughput

0.249

Low

1124073

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.249

Low

1143871

TCAL1
Transcription elongation factor A protein-like 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025