Protein: MILK2
MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2)

Gene: MILK2, MICALL2
Organism: Homo sapiens
Interactions: 142
UniProt ID: Q8IY33

Gene Ontology (top 5):
GO:0001725 - stress fiber
GO:0005886 - plasma membrane
GO:0005911 - cell-cell junction
GO:0005923 - bicellular tight junction
GO:0030036 - actin cytoskeleton organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

773760

ACTN2
Alpha-actinin-2

4

16

High-throughput

0.901

High

555715

ACTN1
Alpha-actinin-1

3

16

High-throughput

0.871

High

955961

RAB8A
Ras-related protein Rab-8A

3

20

Small-scale

0.818

High

1313738

RAB8B
Ras-related protein Rab-8B

2

20

High-throughput

0.811

High

224743

ACTN4
Alpha-actinin-4

2

15

High-throughput

0.783

High

1061536

ACTN3
Alpha-actinin-3

2

16

High-throughput

0.783

High

372526

MYC
Myc proto-oncogene protein

1

11

High-throughput

0.618

High

457541

TBB5
Tubulin beta chain

1

3

High-throughput

0.618

High

896574

VASP
Vasodilator-stimulated phosphoprotein

1

6

High-throughput

0.618

High

902207

RAB13
Ras-related protein Rab-13

1

20

High-throughput

0.618

High

952948

ACTB
Actin, cytoplasmic 1

1

20

High-throughput

0.618

High

997416

TBB4B
Tubulin beta-4B chain

1

3

High-throughput

0.618

High

1313747

ALK
ALK tyrosine kinase receptor

1

17

High-throughput

0.618

High

396474

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1313745

DCDC2
Doublecortin domain-containing protein 2

2

2

High-throughput

0.553

High

996759

TBA1B
Tubulin alpha-1B chain

1

6

High-throughput

0.553

High

1313744

CALL5
Calmodulin-like protein 5

1

4

High-throughput

0.553

High

1023025

FGD1
FYVE, RhoGEF and PH domain-containing protein 1

1

14

High-throughput

0.536

High

876611

NEST
Nestin

1

13

High-throughput

0.489

High

132863

ODPX
Pyruvate dehydrogenase protein X component, mitochondrial

1

4

High-throughput

0.479

High

138207

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

8

High-throughput

0.479

High

380765

HBD
Hemoglobin subunit delta

1

1

High-throughput

0.479

High

408977

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

High-throughput

0.479

High

418701

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

1

High-throughput

0.479

High

424958

ADT2
ADP/ATP translocase 2

1

1

High-throughput

0.479

High

445959

ENOA
Alpha-enolase

1

2

High-throughput

0.479

High

456788

ANXA2
Annexin A2

1

1

High-throughput

0.479

High

471123

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

5

High-throughput

0.479

High

724402

COR1A
Coronin-1A

1

8

High-throughput

0.479

High

940787

LEG4
Galectin-4

1

5

High-throughput

0.479

High

968372

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

7

High-throughput

0.479

High

987102

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

7

High-throughput

0.479

High

994648

YBOX1
Y-box-binding protein 1

1

3

High-throughput

0.479

High

996236

EF1A1
Elongation factor 1-alpha 1

1

2

High-throughput

0.479

High

1024404

S25A3
Solute carrier family 25 member 3

1

3

High-throughput

0.479

High

1113638

CUL3
Cullin-3

1

11

High-throughput

0.479

High

1313736

GTR14
Solute carrier family 2, facilitated glucose transporter member 14

1

5

High-throughput

0.479

High

1313737

RFFL
E3 ubiquitin-protein ligase rififylin

1

10

Small-scale

0.479

High

1313741

PHB2
Prohibitin-2

1

2

High-throughput

0.479

High

1313746

STML2
Stomatin-like protein 2, mitochondrial

1

2

High-throughput

0.479

High

1313752

ATP23
Mitochondrial inner membrane protease ATP23 homolog

1

1

High-throughput

0.479

High

716199

ERP29
Endoplasmic reticulum resident protein 29

1

4

High-throughput

0.470

High

539208

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

0

High-throughput

0.458

High

658267

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

1010666

DCD
Dermcidin

1

0

High-throughput

0.458

High

1313735

NUBPL
Iron-sulfur cluster transfer protein NUBPL

1

0

High-throughput

0.458

High

277738

H2AY
Core histone macro-H2A.1

1

5

High-throughput

0.437

High

283295

ERLN1
Erlin-1

1

1

High-throughput

0.437

High

419073

H2A1B
Histone H2A type 1-B/E

1

3

High-throughput

0.437

High

421191

ALDOB
Fructose-bisphosphate aldolase B

1

1

High-throughput

0.437

High

447205

NPM
Nucleophosmin

1

2

High-throughput

0.437

High

462509

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

7

High-throughput

0.437

High

484592

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

4

High-throughput

0.437

High

595505

H15
Histone H1.5

1

4

High-throughput

0.437

High

596217

H12
Histone H1.2

1

4

High-throughput

0.437

High

612696

RL7
Large ribosomal subunit protein uL30

1

2

High-throughput

0.437

High

623431

RO52
E3 ubiquitin-protein ligase TRIM21

1

3

High-throughput

0.437

High

646885

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

2

High-throughput

0.437

High

650850

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

3

High-throughput

0.437

High

685638

U2AF2
Splicing factor U2AF 65 kDa subunit

1

3

High-throughput

0.437

High

729347

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

5

High-throughput

0.437

High

733959

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

1

High-throughput

0.437

High

775189

FUS
RNA-binding protein FUS

1

4

High-throughput

0.437

High

788093

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

4

High-throughput

0.437

High

842434

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.437

High

859350

RL5
Large ribosomal subunit protein uL18

1

2

High-throughput

0.437

High

909624

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

3

High-throughput

0.437

High

937814

FOXA1
Hepatocyte nuclear factor 3-alpha

1

4

High-throughput

0.437

High

959856

RS3A
Small ribosomal subunit protein eS1

1

1

High-throughput

0.437

High

979049

RS6
Small ribosomal subunit protein eS6

1

2

High-throughput

0.437

High

979957

H4
Histone H4

1

3

High-throughput

0.437

High

998524

H31
Histone H3.1

1

5

High-throughput

0.437

High

1016510

SRSF3
Serine/arginine-rich splicing factor 3

1

3

High-throughput

0.437

High

1059890

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

2

High-throughput

0.437

High

1062044

SRSF4
Serine/arginine-rich splicing factor 4

1

1

High-throughput

0.437

High

1097829

STX5
Syntaxin-5

1

8

High-throughput

0.437

High

1144411

NONO
Non-POU domain-containing octamer-binding protein

1

6

High-throughput

0.437

High

1227030

A16L1
Autophagy-related protein 16-1

1

8

High-throughput

0.437

High

1229559

VIR
Protein virilizer homolog

1

2

High-throughput

0.437

High

1244730

KLD10
Kelch domain-containing protein 10

1

1

High-throughput

0.437

High

1313732

H2B3B
Histone H2B type 3-B

1

7

High-throughput

0.437

High

1313734

LS14A
Protein LSM14 homolog A

1

4

High-throughput

0.437

High

1313751

T22D4
TSC22 domain family protein 4

1

5

High-throughput

0.437

High

1313742

FEZ1
Fasciculation and elongation protein zeta-1

1

0

High-throughput

0.426

High

1033378

CDR2
Cerebellar degeneration-related protein 2

2

0

High-throughput

0.316

High

1313740

PIGS
GPI-anchor transamidase component PIGS

1

0

High-throughput

0.279

Low

1313749

ZN281
Zinc finger protein 281

1

0

High-throughput

0.279

Low

163134

CHK1
Serine/threonine-protein kinase Chk1

1

0

High-throughput

0.249

Low

428851

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.249

Low

586775

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

615861

RL17
Large ribosomal subunit protein uL22

1

0

High-throughput

0.249

Low

686260

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.249

Low

690586

PON1
Serum paraoxonase/arylesterase 1

1

0

High-throughput

0.249

Low

693836

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.249

Low

716906

RL12
Large ribosomal subunit protein uL11

1

0

High-throughput

0.249

Low

723937

LCN1
Lipocalin-1

1

0

High-throughput

0.249

Low

785285

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.249

Low

810205

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.249

Low

824226

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.249

Low

858980

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.249

Low

859897

RL28
Large ribosomal subunit protein eL28

1

0

High-throughput

0.249

Low

860265

RS9
Small ribosomal subunit protein uS4

1

0

High-throughput

0.249

Low

868551

RL29
Large ribosomal subunit protein eL29

1

0

High-throughput

0.249

Low

880337

RL34
Large ribosomal subunit protein eL34

1

0

High-throughput

0.249

Low

898719

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.249

Low

960165

RL26
Large ribosomal subunit protein uL24

1

0

High-throughput

0.249

Low

960792

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.249

Low

961335

RL27
Large ribosomal subunit protein eL27

1

0

High-throughput

0.249

Low

965771

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

0

High-throughput

0.249

Low

967490

RS7
Small ribosomal subunit protein eS7

1

0

High-throughput

0.249

Low

969301

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.249

Low

969965

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.249

Low

972481

RS14
Small ribosomal subunit protein uS11

1

0

High-throughput

0.249

Low

972724

RS23
Small ribosomal subunit protein uS12

1

0

High-throughput

0.249

Low

972906

RS18
Small ribosomal subunit protein uS13

1

0

High-throughput

0.249

Low

973230

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

973496

RS11
Small ribosomal subunit protein uS17

1

0

High-throughput

0.249

Low

975797

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.249

Low

977296

RS4X
Small ribosomal subunit protein eS4, X isoform

1

0

High-throughput

0.249

Low

978603

RL23A
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

981885

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.249

Low

982994

RS25
Small ribosomal subunit protein eS25

1

0

High-throughput

0.249

Low

983172

RS26
Small ribosomal subunit protein eS26

1

0

High-throughput

0.249

Low

985238

RL10A
Large ribosomal subunit protein uL1

1

0

High-throughput

0.249

Low

986102

RL8
Large ribosomal subunit protein uL2

1

0

High-throughput

0.249

Low

1013808

RL24
Large ribosomal subunit protein eL24

1

0

High-throughput

0.249

Low

1016098

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.249

Low

1028674

U2AF1
Splicing factor U2AF 35 kDa subunit

1

0

High-throughput

0.249

Low

1029335

SET
Protein SET

1

0

High-throughput

0.249

Low

1037550

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.249

Low

1039282

RL6
Large ribosomal subunit protein eL6

1

0

High-throughput

0.249

Low

1057801

RL18
Large ribosomal subunit protein eL18

1

0

High-throughput

0.249

Low

1089326

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

1

0

High-throughput

0.249

Low

1089470

ILF2
Interleukin enhancer-binding factor 2

1

0

High-throughput

0.249

Low

1096585

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.249

Low

1100885

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.249

Low

1313733

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.249

Low

1313750

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

High-throughput

0.249

Low

1132522

NAA30
N-alpha-acetyltransferase 30

1

0

High-throughput

0.232

Low

1313739

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.232

Low

1313743

MAT2B
Methionine adenosyltransferase 2 subunit beta

1

0

High-throughput

0.232

Low

1313748

NDRG2
Protein NDRG2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025