Protein: HOOK1
Protein Hook homolog 1 (h-hook1) (hHK1)

Gene: HOOK1
Organism: Homo sapiens
Interactions: 234
UniProt ID: Q9UJC3

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005737 - cytoplasm
GO:0005813 - centrosome
GO:0005874 - microtubule
GO:0007030 - Golgi organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1436475

AKTIP
AKT-interacting protein

11

4

Small-scale

0.981

High

1291602

HOOK3
Protein Hook homolog 3

7

18

Small-scale

0.969

High

1460576

HOOK1
Protein Hook homolog 1

6

18

Small-scale

0.945

High

1328732

FHI1B
FHF complex subunit HOOK-interacting protein 1B

4

13

Small-scale

0.900

High

1053463

FHI1A
FHF complex subunit HOOK-interacting protein 1A

2

13

High-throughput

0.802

High

549258

CDK4
Cyclin-dependent kinase 4

5

13

High-throughput

0.726

High

1458239

TFP11
Tuftelin-interacting protein 11

5

1

High-throughput

0.718

High

1290245

FHI2B
FHF complex subunit HOOK-interacting protein 2B

2

13

High-throughput

0.717

High

1388881

HOOK2
Protein Hook homolog 2

1

19

Small-scale

0.713

High

1404483

CDC5L
Cell division cycle 5-like protein

4

1

High-throughput

0.688

High

1219963

FHI2A
FHF complex subunit HOOK interacting protein 2A

2

13

High-throughput

0.675

High

1460583

TN13B
Tumor necrosis factor ligand superfamily member 13B

3

2

High-throughput

0.667

High

1093077

CDC16
Cell division cycle protein 16 homolog

2

2

High-throughput

0.628

High

1413503

AASD1
Alanyl-tRNA editing protein Aarsd1

2

1

High-throughput

0.628

High

1460585

CRYL1
Lambda-crystallin homolog

2

1

High-throughput

0.628

High

681947

RBTN2
Rhombotin-2

3

5

High-throughput

0.616

High

244877

TRAK2
Trafficking kinesin-binding protein 2

2

18

High-throughput

0.611

High

343099

HERC2
E3 ubiquitin-protein ligase HERC2

2

8

High-throughput

0.611

High

921578

PGTB2
Geranylgeranyl transferase type-2 subunit beta

3

2

High-throughput

0.609

High

1185338

F161A
Protein FAM161A

2

4

High-throughput

0.606

High

1330249

ZN655
Zinc finger protein 655

2

3

High-throughput

0.606

High

1098686

SBP1
Methanethiol oxidase

2

0

High-throughput

0.602

High

1322156

SYCE1
Synaptonemal complex central element protein 1

2

2

High-throughput

0.588

High

246179

KIF1B
Kinesin-like protein KIF1B

2

15

High-throughput

0.584

High

1104278

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

2

6

High-throughput

0.584

High

1211463

CF141
Uncharacterized protein C6orf141

2

1

High-throughput

0.574

High

1233812

CNDH2
Condensin-2 complex subunit H2

2

1

High-throughput

0.574

High

288535

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

18

High-throughput

0.573

High

1385714

ENTR1
Endosome-associated-trafficking regulator 1

2

0

High-throughput

0.559

High

1460581

AP4E1
AP-4 complex subunit epsilon-1

2

7

Small-scale

0.558

High

1460592

AP4B1
AP-4 complex subunit beta-1

2

5

Small-scale

0.558

High

297880

PIAS2
E3 SUMO-protein ligase PIAS2

2

2

High-throughput

0.553

High

567196

ZNF35
Zinc finger protein 35

2

4

High-throughput

0.553

High

902985

ZNF80
Zinc finger protein 80

2

4

High-throughput

0.553

High

1180516

C19L2
CWF19-like protein 2

2

2

High-throughput

0.553

High

1215305

UT14C
U3 small nucleolar RNA-associated protein 14 homolog C

2

5

High-throughput

0.553

High

1277132

ZN572
Zinc finger protein 572

2

4

High-throughput

0.553

High

1286331

ANR23
Ankyrin repeat domain-containing protein 23

2

13

High-throughput

0.553

High

1392752

ZN764
Zinc finger protein 764

2

4

High-throughput

0.553

High

1459094

ZBT47
Zinc finger and BTB domain-containing protein 47

2

8

High-throughput

0.553

High

125856

AP4M1
AP-4 complex subunit mu-1

2

8

Small-scale

0.548

High

72435

MI4GD
MIF4G domain-containing protein

1

2

High-throughput

0.536

High

391516

FRIL
Ferritin light chain

1

3

High-throughput

0.536

High

1152289

MARE1
Microtubule-associated protein RP/EB family member 1

1

4

High-throughput

0.536

High

1178912

CF184
Cilia- and flagella-associated protein 184

1

1

High-throughput

0.536

High

1383888

EFMT3
EEF1A lysine methyltransferase 3

1

9

High-throughput

0.536

High

1417901

DUS16
Dual specificity protein phosphatase 16

1

7

High-throughput

0.536

High

1420255

UBXN6
UBX domain-containing protein 6

1

2

High-throughput

0.536

High

213497

CTIF
CBP80/20-dependent translation initiation factor

2

2

High-throughput

0.533

High

69838

ZN785
Zinc finger protein 785

1

3

High-throughput

0.523

High

423418

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.515

High

1025520

CDK5
Cyclin-dependent kinase 5

1

16

High-throughput

0.515

High

296843

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.513

High

1207273

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

0

High-throughput

0.513

High

585111

ZN250
Zinc finger protein 250

1

1

High-throughput

0.494

High

158515

RFXK
DNA-binding protein RFXANK

1

7

High-throughput

0.489

High

300854

KRT38
Keratin, type I cuticular Ha8

1

20

High-throughput

0.489

High

584050

FOSL1
Fos-related antigen 1

1

4

High-throughput

0.489

High

1101700

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

7

High-throughput

0.489

High

1102964

ITAD
Integrin alpha-D

1

5

High-throughput

0.489

High

1331617

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

19

High-throughput

0.489

High

1365942

RUBIC
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein

1

1

High-throughput

0.489

High

1407010

NPAS1
Neuronal PAS domain-containing protein 1

1

9

High-throughput

0.489

High

1418705

LOXE3
Hydroperoxide isomerase ALOXE3

1

1

High-throughput

0.489

High

1453205

GPC5D
G-protein coupled receptor family C group 5 member D

1

3

High-throughput

0.489

High

321687

PRP6
Pre-mRNA-processing factor 6

1

1

High-throughput

0.481

High

894234

MEOX2
Homeobox protein MOX-2

1

5

High-throughput

0.481

High

967596

RS7
Small ribosomal subunit protein eS7

1

1

High-throughput

0.481

High

1112770

CUL1
Cullin-1

1

15

High-throughput

0.481

High

1241887

DEN1B
DENN domain-containing protein 1B

1

4

High-throughput

0.481

High

1371324

KAT5
Histone acetyltransferase KAT5

1

2

High-throughput

0.481

High

127795

IKBE
NF-kappa-B inhibitor epsilon

1

13

High-throughput

0.479

High

208585

PJA2
E3 ubiquitin-protein ligase Praja-2

1

7

High-throughput

0.479

High

214632

WDR62
WD repeat-containing protein 62

1

9

High-throughput

0.479

High

230586

KIF1C
Kinesin-like protein KIF1C

1

15

High-throughput

0.479

High

243236

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

244193

KIF5C
Kinesin heavy chain isoform 5C

1

6

High-throughput

0.479

High

244616

SI1L3
Signal-induced proliferation-associated 1-like protein 3

1

8

High-throughput

0.479

High

294500

CD123
Translation initiation factor eIF2 assembly protein

1

4

High-throughput

0.479

High

317261

AL1A2
Retinal dehydrogenase 2

1

2

High-throughput

0.479

High

322475

HAUS5
HAUS augmin-like complex subunit 5

1

1

High-throughput

0.479

High

326085

UBR5
E3 ubiquitin-protein ligase UBR5

1

11

High-throughput

0.479

High

336509

SVIL
Supervillin

1

14

High-throughput

0.479

High

351186

ECD
Protein ecdysoneless homolog

1

1

High-throughput

0.479

High

363996

EGFR
Epidermal growth factor receptor

1

12

High-throughput

0.479

High

456884

ANXA2
Annexin A2

1

8

High-throughput

0.479

High

475055

VIME
Vimentin

1

8

High-throughput

0.479

High

539434

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

5

High-throughput

0.479

High

547220

PYC
Pyruvate carboxylase, mitochondrial

1

8

High-throughput

0.479

High

555821

ACE
Angiotensin-converting enzyme

1

4

High-throughput

0.479

High

610935

TCPA
T-complex protein 1 subunit alpha

1

2

High-throughput

0.479

High

626395

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

15

High-throughput

0.479

High

631546

RAB5A
Ras-related protein Rab-5A

1

5

High-throughput

0.479

High

750021

KINH
Kinesin-1 heavy chain

1

8

High-throughput

0.479

High

888822

VPS41
Vacuolar protein sorting-associated protein 41 homolog

1

8

Small-scale

0.479

High

896330

PEX5
Peroxisomal targeting signal 1 receptor

1

3

High-throughput

0.479

High

915214

CAZA1
F-actin-capping protein subunit alpha-1

1

10

High-throughput

0.479

High

935261

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.479

High

936680

BRPF1
Peregrin

1

8

High-throughput

0.479

High

958537

ACTZ
Alpha-centractin

1

20

High-throughput

0.479

High

1007332

TCPB
T-complex protein 1 subunit beta

1

3

High-throughput

0.479

High

1014976

ARF1
ADP-ribosylation factor 1

1

3

High-throughput

0.479

High

1022664

LRP2
Low-density lipoprotein receptor-related protein 2

1

3

High-throughput

0.479

High

1045885

TF65
Transcription factor p65

1

6

High-throughput

0.479

High

1049887

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1060586

KLC1
Kinesin light chain 1

1

5

High-throughput

0.479

High

1085203

WASC5
WASH complex subunit 5

1

1

High-throughput

0.479

High

1123863

DCTN1
Dynactin subunit 1

1

18

High-throughput

0.479

High

1124082

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

6

High-throughput

0.479

High

1150962

TRIPB
Thyroid receptor-interacting protein 11

1

19

High-throughput

0.479

High

1161253

MK06
Mitogen-activated protein kinase 6

1

15

High-throughput

0.479

High

1225391

WAC2A
WASH complex subunit 2A

1

2

High-throughput

0.479

High

1241133

C2D1A
Coiled-coil and C2 domain-containing protein 1A

1

5

High-throughput

0.479

High

1247916

C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial

1

3

High-throughput

0.479

High

1251278

DNMBP
Dynamin-binding protein

1

20

High-throughput

0.479

High

1257771

VP13C
Intermembrane lipid transfer protein VPS13C

1

2

High-throughput

0.479

High

1277801

MYH14
Myosin-14

1

14

High-throughput

0.479

High

1313719

IFT20
Intraflagellar transport protein 20 homolog

1

1

High-throughput

0.479

High

1313940

DHX37
Probable ATP-dependent RNA helicase DHX37

1

1

High-throughput

0.479

High

1329363

ARFG2
ADP-ribosylation factor GTPase-activating protein 2

1

1

High-throughput

0.479

High

1339021

NUP43
Nucleoporin Nup43

1

11

High-throughput

0.479

High

1364663

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

8

High-throughput

0.479

High

1365261

HS105
Heat shock protein 105 kDa

1

8

High-throughput

0.479

High

1386300

HAUS1
HAUS augmin-like complex subunit 1

1

1

High-throughput

0.479

High

1394872

VPS39
Vam6/Vps39-like protein

1

18

Small-scale

0.479

High

1395784

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

20

High-throughput

0.479

High

1396982

IFT74
Intraflagellar transport protein 74 homolog

1

19

High-throughput

0.479

High

1399783

RBM14
RNA-binding protein 14

1

4

High-throughput

0.479

High

1407623

TCPH
T-complex protein 1 subunit eta

1

2

High-throughput

0.479

High

1415980

IFT27
Intraflagellar transport protein 27 homolog

1

12

High-throughput

0.479

High

1420899

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

9

High-throughput

0.479

High

1429717

KLC2
Kinesin light chain 2

1

6

High-throughput

0.479

High

1431142

RBNS5
Rabenosyn-5

1

8

High-throughput

0.479

High

1431587

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

2

Small-scale

0.479

High

1434177

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

1435941

IFT22
Intraflagellar transport protein 22 homolog

1

5

High-throughput

0.479

High

1448116

4ET
Eukaryotic translation initiation factor 4E transporter

1

1

High-throughput

0.479

High

1449434

KLC4
Kinesin light chain 4

1

5

High-throughput

0.479

High

1450872

PAPD1
Poly(A) RNA polymerase, mitochondrial

1

1

High-throughput

0.479

High

1452519

ABI2
Abl interactor 2

1

18

High-throughput

0.479

High

1453581

LRP1B
Low-density lipoprotein receptor-related protein 1B

1

8

High-throughput

0.479

High

1454280

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

6

Small-scale

0.479

High

1454407

BCCIP
BRCA2 and CDKN1A-interacting protein

1

1

High-throughput

0.479

High

1454563

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

6

High-throughput

0.479

High

1458910

AASS
Alpha-aminoadipic semialdehyde synthase, mitochondrial

1

1

High-throughput

0.479

High

1459109

RIM3A
RIMS-binding protein 3A

1

18

High-throughput

0.479

High

1459234

ZRAN1
Ubiquitin thioesterase ZRANB1

1

14

High-throughput

0.479

High

1459825

TBK1
Serine/threonine-protein kinase TBK1

1

20

High-throughput

0.479

High

1460577

TNIK
TRAF2 and NCK-interacting protein kinase

1

19

High-throughput

0.479

High

1460582

PZRN3
E3 ubiquitin-protein ligase PDZRN3

1

14

High-throughput

0.479

High

1460586

GIT1
ARF GTPase-activating protein GIT1

1

4

High-throughput

0.479

High

1460593

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

3

High-throughput

0.479

High

1162075

H31T
Histone H3.1t

1

8

High-throughput

0.470

High

278448

NCOR1
Nuclear receptor corepressor 1

1

18

High-throughput

0.470

High

1232629

Q6FHY5
MEOX2 protein

1

5

High-throughput

0.470

High

1451081

RBM22
Pre-mRNA-splicing factor RBM22

1

0

High-throughput

0.460

High

48181

IFT56
Intraflagellar transport protein 56

1

0

High-throughput

0.458

High

1228580

HAUS3
HAUS augmin-like complex subunit 3

1

0

High-throughput

0.458

High

1434896

HAUS4
HAUS augmin-like complex subunit 4

1

0

High-throughput

0.458

High

1447061

IFT46
Intraflagellar transport protein 46 homolog

1

0

High-throughput

0.458

High

1460580

SUFU
Suppressor of fused homolog

1

0

High-throughput

0.458

High

58965

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

4

High-throughput

0.445

High

1111343

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.439

High

1358680

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

1

3

High-throughput

0.439

High

1385273

LENG1
Leukocyte receptor cluster member 1

1

1

High-throughput

0.439

High

1415368

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

4

High-throughput

0.439

High

1417324

AP1M1
AP-1 complex subunit mu-1

1

8

Small-scale

0.439

High

157964

CTRO
Citron Rho-interacting kinase

1

20

High-throughput

0.437

High

177327

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

9

High-throughput

0.437

High

262145

NBN
Nibrin

1

1

High-throughput

0.437

High

425860

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

8

High-throughput

0.437

High

425974

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

5

High-throughput

0.437

High

475717

K1C19
Keratin, type I cytoskeletal 19

1

12

High-throughput

0.437

High

483413

CLCB
Clathrin light chain B

1

5

High-throughput

0.437

High

522001

H14
Histone H1.4

1

5

High-throughput

0.437

High

589982

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.437

High

729491

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

3

High-throughput

0.437

High

769460

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

772348

FBN2
Fibrillin-2 [Cleaved into: Placensin]

1

4

High-throughput

0.437

High

774698

BASI
Basigin

1

5

Small-scale

0.437

High

878579

PAXI
Paxillin

1

13

High-throughput

0.437

High

952666

MYL6
Myosin light polypeptide 6

1

20

High-throughput

0.437

High

968829

PRS4
26S proteasome regulatory subunit 4

1

2

High-throughput

0.437

High

1094279

ACACA
Acetyl-CoA carboxylase 1

1

8

High-throughput

0.437

High

1143299

PLEC
Plectin

1

17

High-throughput

0.437

High

1147582

UBE3C
Ubiquitin-protein ligase E3C

1

9

High-throughput

0.437

High

1180334

ATG2A
Autophagy-related protein 2 homolog A

1

2

High-throughput

0.437

High

1203630

ZN326
DBIRD complex subunit ZNF326

1

1

High-throughput

0.437

High

1204819

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

3

High-throughput

0.437

High

1225983

F91A1
Protein FAM91A1

1

1

High-throughput

0.437

High

1229752

VIR
Protein virilizer homolog

1

2

High-throughput

0.437

High

1241977

FBX42
F-box only protein 42

1

10

High-throughput

0.437

High

1249312

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1251974

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

High-throughput

0.437

High

1309914

TEX2
Testis-expressed protein 2

1

1

High-throughput

0.437

High

1332249

KRI1
Protein KRI1 homolog

1

1

High-throughput

0.437

High

1369796

RAD50
DNA repair protein RAD50

1

20

High-throughput

0.437

High

1389416

RNF31
E3 ubiquitin-protein ligase RNF31

1

13

High-throughput

0.437

High

1400270

LENG8
Leukocyte receptor cluster member 8

1

1

High-throughput

0.437

High

1401780

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

8

High-throughput

0.437

High

1411670

GPTC1
G patch domain-containing protein 1

1

3

High-throughput

0.437

High

1438819

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

5

High-throughput

0.437

High

1439178

Q9HCK3
KIAA1569 protein

1

1

High-throughput

0.437

High

1448940

VPS45
Vacuolar protein sorting-associated protein 45

1

6

High-throughput

0.437

High

1458929

ZO2
Tight junction protein 2

1

10

High-throughput

0.437

High

1460578

RAB21
Ras-related protein Rab-21

1

8

High-throughput

0.437

High

1460579

MRTFB
Myocardin-related transcription factor B

1

6

High-throughput

0.437

High

1460590

FARP1
FERM, ARHGEF and pleckstrin domain-containing protein 1

1

10

High-throughput

0.437

High

1460591

HYOU1
Hypoxia up-regulated protein 1

1

9

High-throughput

0.437

High

171612

S27A2
Long-chain fatty acid transport protein 2

1

6

High-throughput

0.407

High

1010979

BAT1
b(0,+)-type amino acid transporter 1

1

2

High-throughput

0.407

High

1167129

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

4

High-throughput

0.407

High

1253677

PKHG7
Pleckstrin homology domain-containing family G member 7

1

11

High-throughput

0.407

High

1420754

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.407

High

1453949

TBCD7
TBC1 domain family member 7

4

0

High-throughput

0.364

High

1390451

ZB10P
Putative protein ZBED10P

1

0

High-throughput

0.279

Low

1137684

EXOS7
Exosome complex component RRP42

1

0

High-throughput

0.251

Low

1387419

ESS2
Splicing factor ESS-2 homolog

1

0

High-throughput

0.251

Low

1437187

UNKL
Putative E3 ubiquitin-protein ligase UNKL

1

0

High-throughput

0.251

Low

1460589

CCDC9
Coiled-coil domain-containing protein 9

1

0

High-throughput

0.251

Low

1040233

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

0

High-throughput

0.249

Low

1054213

P2R3A
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

1

0

High-throughput

0.249

Low

1131712

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

0

High-throughput

0.249

Low

1178454

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1206635

AMER1
APC membrane recruitment protein 1

1

0

High-throughput

0.249

Low

1258205

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

1

0

High-throughput

0.249

Low

1289207

N4BP2
NEDD4-binding protein 2

1

0

High-throughput

0.249

Low

1366102

K0232
Uncharacterized protein KIAA0232

1

0

High-throughput

0.249

Low

1417937

K1671
Uncharacterized protein KIAA1671

1

0

High-throughput

0.249

Low

1453030

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

1460584

NCKP1
Nck-associated protein 1

1

0

High-throughput

0.249

Low

1460587

TMED5
Transmembrane emp24 domain-containing protein 5

1

0

High-throughput

0.249

Low

1460588

NOC2L
Nucleolar complex protein 2 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025