Protein: AACS
Acetoacetyl-CoA synthetase (EC 6.2.1.16) (Acyl-CoA synthetase family member 1) (Protein sur-5 homolog)

Gene: AACS
Organism: Homo sapiens
Interactions: 27
UniProt ID: Q86V21

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0006631 - fatty acid metabolic process
GO:0030729 - acetoacetate-CoA ligase activity
GO:0032024 - positive regulation of insulin secretion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1289809

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

2

High-throughput

0.523

High

1289808

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1289811

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

1

High-throughput

0.489

High

1141746

EEA1
Early endosome antigen 1

1

2

High-throughput

0.479

High

142364

PEX7
Peroxisomal targeting signal 2 receptor

1

6

High-throughput

0.445

High

730729

1433S
14-3-3 protein sigma

1

2

High-throughput

0.445

High

896407

ERF
ETS domain-containing transcription factor ERF

1

1

High-throughput

0.445

High

1239230

ARMC6
Armadillo repeat-containing protein 6

1

1

High-throughput

0.445

High

1289805

FXL16
F-box/LRR-repeat protein 16

1

1

High-throughput

0.445

High

1289807

SPSB4
SPRY domain-containing SOCS box protein 4

1

8

High-throughput

0.445

High

589063

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

695852

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

768562

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

1254463

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

1289810

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

248902

GSDME
Gasdermin-E

1

0

High-throughput

0.426

High

261211

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.407

High

330226

VENTX
Homeobox protein VENTX

1

2

High-throughput

0.407

High

437720

HEPS
Serine protease hepsin

1

1

High-throughput

0.407

High

628420

KLK2
Kallikrein-2

1

6

High-throughput

0.407

High

914440

EFNB2
Ephrin-B2

1

1

High-throughput

0.407

High

1289806

LPAR1
Lysophosphatidic acid receptor 1

1

4

High-throughput

0.407

High

750563

CP2CI
Cytochrome P450 2C18

1

0

High-throughput

0.279

Low

1055128

CCG1
Voltage-dependent calcium channel gamma-1 subunit

1

0

High-throughput

0.279

Low

466932

ACM4
Muscarinic acetylcholine receptor M4

1

0

High-throughput

0.232

Low

607945

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

0

High-throughput

0.232

Low

1030184

IL5RA
Interleukin-5 receptor subunit alpha

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025