Protein: ASC
Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein)

Gene: ASC, Pycard
Organism: Mus musculus
Interactions: 17
UniProt ID: Q9EPB4

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0002020 - protease binding
GO:0002218 - activation of innate immune response
GO:0002221 - pattern recognition receptor signaling pathway
GO:0002230 - positive regulation of defense response to virus by host

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1341594

NLRP3
NACHT, LRR and PYD domains-containing protein 3

13

17

Small-scale

0.974

High

712517

CASP1
Caspase-1

4

16

Small-scale

0.875

High

1424306

ASC
Apoptosis-associated speck-like protein containing a CARD

3

18

Small-scale

0.830

High

1362212

AIM2
Interferon-inducible protein AIM2

2

2

Small-scale

0.754

High

1190721

NLRC4
NLR family CARD domain-containing protein 4

1

18

Small-scale

0.646

High

1221546

TRAF3
TNF receptor-associated factor 3

1

9

Small-scale

0.479

High

1225677

SQSTM
Sequestosome-1

1

4

Small-scale

0.479

High

1243168

UBP50
Ubiquitin carboxyl-terminal hydrolase 50

1

3

Small-scale

0.479

High

1298093

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

1

Small-scale

0.479

High

1353881

MAVS
Mitochondrial antiviral-signaling protein

1

2

Small-scale

0.479

High

1362366

MK08
Mitogen-activated protein kinase 8

1

1

Small-scale

0.479

High

312669

BECN1
Beclin-1

1

8

Small-scale

0.445

High

869555

KSYK
Tyrosine-protein kinase SYK

1

6

Small-scale

0.445

High

1424308

RALB
Ras-related protein Ral-B

1

2

Small-scale

0.445

High

940750

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

6

Small-scale

0.437

High

1424307

PANX1
Pannexin-1 [Cleaved into: Caspase-activated pannexin-1

1

0

Small-scale

0.426

High


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Last updated: 11Aug2025