Protein: GLYC
Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)

Gene: GLYC, SHM2
Organism: Saccharomyces cerevisiae S288C
Interactions: 92
UniProt ID: P37291

Gene Ontology (top 5):
GO:0004372 - glycine hydroxymethyltransferase activity
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005886 - plasma membrane
GO:0006730 - one-carbon metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

523663

HSP71
Heat shock protein SSA1

3

4

High-throughput

0.633

High

526448

HSP72
Heat shock protein SSA2

3

4

High-throughput

0.624

High

544536

SSB1
Ribosome-associated molecular chaperone SSB1

3

4

High-throughput

0.624

High

464585

PBS2
MAP kinase kinase PBS2

2

3

High-throughput

0.601

High

392580

HSP82
ATP-dependent molecular chaperone HSP82

2

3

High-throughput

0.584

High

626695

HSP60
Heat shock protein 60, mitochondrial

2

2

High-throughput

0.571

High

741393

HSP7F
Heat shock protein homolog SSE1

2

6

High-throughput

0.552

High

790204

SSB2
Ribosome-associated molecular chaperone SSB2

2

4

High-throughput

0.552

High

670586

SIS1
Protein SIS1

2

2

High-throughput

0.537

High

790220

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

3

High-throughput

0.536

High

743816

FRDS
Fumarate reductase 1

1

1

High-throughput

0.515

High

790213

LYS4
Homoaconitase, mitochondrial

1

2

High-throughput

0.515

High

454433

PHO4
Phosphate system positive regulatory protein PHO4

1

0

High-throughput

0.513

High

460963

LTE1
Guanine nucleotide exchange factor LTE1

1

0

High-throughput

0.513

High

517995

SSBP1
Single-stranded nucleic acid-binding protein

1

1

High-throughput

0.501

High

617385

GBB
Guanine nucleotide-binding protein subunit beta

1

1

High-throughput

0.500

High

790238

ARP6
Actin-like protein ARP6

1

0

High-throughput

0.493

High

645913

DBF2
Cell cycle protein kinase DBF2

1

1

High-throughput

0.489

High

790218

RHO5
GTP-binding protein RHO5

1

1

Small-scale

0.481

High

737303

CDC12
Cell division control protein 12

1

0

High-throughput

0.479

High

751381

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.479

High

469988

FUMH
Fumarate hydratase, mitochondrial

1

1

High-throughput

0.479

High

579224

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.479

High

645720

HSP74
Heat shock protein SSA4

1

4

High-throughput

0.479

High

674565

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

679584

CDC48
Cell division control protein 48

1

2

High-throughput

0.479

High

704589

SBA1
Co-chaperone protein SBA1

1

1

High-throughput

0.479

High

726947

HS104
Heat shock protein 104

1

3

High-throughput

0.479

High

750632

PRS6A
26S proteasome regulatory subunit 6A

1

1

High-throughput

0.479

High

752150

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.479

High

790193

ATG8
Autophagy-related protein 8

1

1

High-throughput

0.479

High

790196

UBA4
Adenylyltransferase and sulfurtransferase UBA4

1

2

High-throughput

0.479

High

790201

DHH1
ATP-dependent RNA helicase DHH1

1

3

High-throughput

0.479

High

790205

TM108
Protein TMA108

1

2

High-throughput

0.479

High

790211

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

1

High-throughput

0.479

High

790217

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

790219

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

790223

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.479

High

790228

RQC1
Ribosome quality control complex subunit 1

1

1

Small-scale

0.479

High

790231

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

2

Small-scale

0.479

High

790234

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.479

High

790236

PSH1
RING finger protein PSH1

1

2

High-throughput

0.470

High

365022

KPYK1
Pyruvate kinase 1

1

0

Small-scale

0.458

High

368434

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

401976

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.458

High

435021

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

531304

METK1
S-adenosylmethionine synthase 1

1

0

Small-scale

0.458

High

558679

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

645387

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.458

High

737827

HOG1
Mitogen-activated protein kinase HOG1

1

0

High-throughput

0.458

High

747804

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

790195

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

790197

DNPEP
Aspartyl aminopeptidase 4

1

0

High-throughput

0.458

High

790206

SER33
D-3-phosphoglycerate dehydrogenase 2

1

0

Small-scale

0.458

High

790207

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.458

High

790214

SKP1
Suppressor of kinetochore protein 1

1

0

Small-scale

0.458

High

790222

ESP1
Separin

1

0

High-throughput

0.458

High

790226

SEG1
Eisosome protein SEG1

1

0

Small-scale

0.458

High

748161

SUI1
Eukaryotic translation initiation factor eIF-1

1

1

High-throughput

0.457

High

790200

CAJ1
Protein CAJ1

1

2

High-throughput

0.445

High

790208

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.439

High

790221

ULP1
Ubiquitin-like-specific protease 1

1

1

High-throughput

0.439

High

441854

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.437

High

645152

PSB4
Proteasome subunit beta type-4

1

3

Small-scale

0.437

High

706839

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

790192

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

790198

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

1

Small-scale

0.437

High

790202

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

790227

POB3
FACT complex subunit POB3

1

1

High-throughput

0.437

High

790229

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

790230

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.437

High

790233

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

790237

DBP10
ATP-dependent RNA helicase DBP10

1

4

High-throughput

0.437

High

394465

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

734074

EF2
Elongation factor 2

1

2

High-throughput

0.407

High

790224

GCN5
Histone acetyltransferase GCN5

1

1

High-throughput

0.407

High

643267

BAS1
Myb-like DNA-binding protein BAS1

2

0

High-throughput

0.323

High

575435

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

2

0

High-throughput

0.307

High

790210

GCN20
Protein GCN20

2

0

High-throughput

0.307

High

790194

RFC3
Replication factor C subunit 3

1

0

High-throughput

0.279

Low

790232

PRP11
Pre-mRNA-splicing factor PRP11

1

0

High-throughput

0.279

Low

676799

BUD3
Bud site selection protein 3

1

0

High-throughput

0.269

Low

790235

TGL5
Triacylglycerol lipase 5

1

0

High-throughput

0.269

Low

790203

LSM5
LSM complex subunit LSM5

1

0

High-throughput

0.265

Low

459074

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.261

Low

790216

SEH1
Nucleoporin SEH1

1

0

High-throughput

0.261

Low

790199

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.249

Low

790209

BRE2
COMPASS component BRE2

1

0

Small-scale

0.249

Low

790212

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

790215

ACS2
Acetyl-coenzyme A synthetase 2

1

0

Small-scale

0.249

Low

790225

ESC1
Silent chromatin protein ESC1

1

0

High-throughput

0.249

Low

790239

H2AZ
Histone H2A.Z

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025