Protein: FES1
Hsp70 nucleotide exchange factor FES1 (Factor exchange for SSA1 protein 1)

Gene: FES1
Organism: Saccharomyces cerevisiae S288C
Interactions: 48
UniProt ID: P38260

Gene Ontology (top 5):
GO:0000774 - adenyl-nucleotide exchange factor activity
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol
GO:0006417 - regulation of translation
GO:0071629 - cytoplasm protein quality control by the ubiquitin-proteasome system

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

523748

HSP71
Heat shock protein SSA1

11

9

Small-scale

0.756

High

526524

HSP72
Heat shock protein SSA2

6

11

Small-scale

0.728

High

544647

SSB1
Ribosome-associated molecular chaperone SSB1

6

9

Small-scale

0.721

High

796783

SSB2
Ribosome-associated molecular chaperone SSB2

3

9

Small-scale

0.641

High

741455

HSP7F
Heat shock protein homolog SSE1

3

12

High-throughput

0.624

High

645726

HSP74
Heat shock protein SSA4

2

9

Small-scale

0.586

High

670619

SIS1
Protein SIS1

2

1

Small-scale

0.586

High

518273

IF4A
ATP-dependent RNA helicase eIF4A

2

1

High-throughput

0.537

High

796788

LSG1
Large subunit GTPase 1

1

0

High-throughput

0.493

High

479679

F16P
Fructose-1,6-bisphosphatase

1

0

Small-scale

0.480

High

579285

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.479

High

672651

BPH1
Beige protein homolog 1

1

2

High-throughput

0.479

High

779534

LHS1
Heat shock protein 70 homolog LHS1

1

12

High-throughput

0.479

High

796791

PIN3
[PSI+] inducibility protein 3

1

2

High-throughput

0.464

High

673093

RNQ1
[PIN+] prion protein RNQ1

1

0

High-throughput

0.458

High

796789

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

0

Small-scale

0.458

High

796797

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

392635

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.445

High

796781

CAJ1
Protein CAJ1

1

2

High-throughput

0.445

High

796792

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

2

High-throughput

0.445

High

617858

DDR48
Stress protein DDR48

1

0

High-throughput

0.438

High

796785

PHO86
Inorganic phosphate transporter PHO86

1

0

High-throughput

0.438

High

796795

PLB3
Lysophospholipase 3

1

0

High-throughput

0.438

High

394493

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

453560

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

531713

RL4A
Large ribosomal subunit protein uL4A

1

0

High-throughput

0.426

High

792697

GLRX7
Monothiol glutaredoxin-7

1

1

High-throughput

0.417

High

796784

AIP1
Actin-interacting protein 1

1

1

High-throughput

0.417

High

386684

TBB
Tubulin beta chain

1

1

High-throughput

0.407

High

510432

HSP77
Import motor subunit, mitochondrial

1

12

High-throughput

0.407

High

796780

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.407

High

796782

HSP7E
Heat shock protein SSC3, mitochondrial

1

13

High-throughput

0.407

High

796798

HSP42
Heat shock protein 42

3

0

High-throughput

0.330

High

796793

CND3
Condensin complex subunit 3

1

0

High-throughput

0.282

High

458958

LYS2
L-2-aminoadipate reductase

1

0

High-throughput

0.269

Low

561680

RPOM
DNA-directed RNA polymerase, mitochondrial

1

0

Small-scale

0.251

Low

706922

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

796796

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

150049

YP136
Putative uncharacterized protein YPL136W

1

0

High-throughput

0.238

Low

654599

AIM17
Probable oxidoreductase AIM17

1

0

High-throughput

0.238

Low

778890

NNK1
Nitrogen network kinase 1

1

0

High-throughput

0.238

Low

796790

NCW2
Cell wall biogenesis protein NCW2

1

0

High-throughput

0.238

Low

796794

BUD20
Bud site selection protein 20

1

0

High-throughput

0.238

Low

796799

MHT1
Homocysteine S-methyltransferase 1

1

0

High-throughput

0.238

Low

592200

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

752186

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low

796786

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.232

Low

796787

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025