Protein: MBRL
Membralin (Transmembrane protein 259)

Gene: MBRL, TMEM259
Organism: Homo sapiens
Interactions: 111
UniProt ID: Q4ZIN3

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0034976 - response to endoplasmic reticulum stress
GO:1904294 - positive regulation of ERAD pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1197265

RN185
E3 ubiquitin-protein ligase RNF185

4

2

Small-scale

0.694

High

1197294

SRPRB
Signal recognition particle receptor subunit beta

4

0

Small-scale

0.653

High

698722

CALX
Calnexin

3

1

Small-scale

0.633

High

321253

ERLN2
Erlin-2

2

1

Small-scale

0.611

High

1197244

TMUB2
Transmembrane and ubiquitin-like domain-containing protein 2

3

1

Small-scale

0.609

High

1197252

VMA12
Vacuolar ATPase assembly protein VMA12

2

0

High-throughput

0.602

High

1086002

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

0

High-throughput

0.576

High

1197235

DIK1A
Divergent protein kinase domain 1A

2

0

High-throughput

0.576

High

458421

ADRB2
Beta-2 adrenergic receptor

2

1

High-throughput

0.561

High

638198

S1PR1
Sphingosine 1-phosphate receptor 1

2

5

High-throughput

0.549

High

1197263

SPSB4
SPRY domain-containing SOCS box protein 4

2

2

High-throughput

0.549

High

522105

BCL2
Apoptosis regulator Bcl-2

1

1

High-throughput

0.536

High

762133

CNR2
Cannabinoid receptor 2

1

4

Small-scale

0.536

High

1060178

B2CL1
Bcl-2-like protein 1

1

1

High-throughput

0.536

High

1197273

RNF5
E3 ubiquitin-protein ligase RNF5

1

2

High-throughput

0.536

High

931378

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

2

1

Small-scale

0.533

High

1197276

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

2

1

Small-scale

0.533

High

1197250

S15A3
Solute carrier family 15 member 3

2

1

High-throughput

0.521

High

230797

EXTL3
Exostosin-like 3

1

0

High-throughput

0.513

High

323996

CSTN1
Calsyntenin-1

1

0

High-throughput

0.513

High

460260

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

0

High-throughput

0.513

High

1197249

STING
Stimulator of interferon genes protein

1

0

High-throughput

0.513

High

1197258

TLC3A
TLC domain-containing protein 3A

1

0

High-throughput

0.513

High

1197275

EMC6
ER membrane protein complex subunit 6

1

0

High-throughput

0.513

High

251906

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

0

High-throughput

0.493

High

182555

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.489

High

351902

S1PR4
Sphingosine 1-phosphate receptor 4

1

5

High-throughput

0.489

High

420805

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

1

High-throughput

0.489

High

640391

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

3

High-throughput

0.489

High

669270

PTAFR
Platelet-activating factor receptor

1

3

High-throughput

0.489

High

722852

SSR1
Somatostatin receptor type 1

1

1

High-throughput

0.489

High

732925

GASR
Gastrin/cholecystokinin type B receptor

1

1

High-throughput

0.489

High

833823

P2RY2
P2Y purinoceptor 2

1

4

High-throughput

0.489

High

1197248

LHPL1
LHFPL tetraspan subfamily member 1 protein

1

1

High-throughput

0.489

High

1197257

LHPL5
LHFPL tetraspan subfamily member 5 protein

1

1

High-throughput

0.489

High

1197270

SPSB2
SPRY domain-containing SOCS box protein 2

1

2

High-throughput

0.489

High

1197271

GPR21
Probable G-protein coupled receptor 21

1

2

High-throughput

0.489

High

1197272

CML1
Chemerin-like receptor 1

1

4

High-throughput

0.489

High

1197282

GP173
Probable G-protein coupled receptor 173

1

3

High-throughput

0.489

High

1197283

GPR27
Probable G-protein coupled receptor 27

1

3

High-throughput

0.489

High

283269

ERLN1
Erlin-1

1

1

Small-scale

0.479

High

1197287

ZDHC7
Palmitoyltransferase ZDHHC7

1

1

High-throughput

0.479

High

158225

COPE
Coatomer subunit epsilon

1

0

Small-scale

0.458

High

894786

EMD
Emerin

1

0

Small-scale

0.458

High

1164108

CP51A
Lanosterol 14-alpha demethylase

1

0

Small-scale

0.458

High

1197233

MBRL
Membralin

1

0

Small-scale

0.458

High

1197242

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1197261

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.458

High

170790

CLGN
Calmegin

1

1

High-throughput

0.445

High

1197293

ZDHC9
Palmitoyltransferase ZDHHC9

1

1

High-throughput

0.445

High

1197243

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1197240

S27A1
Long-chain fatty acid transport protein 1

1

0

High-throughput

0.426

High

1197245

RIC3
Protein RIC-3

1

0

High-throughput

0.426

High

1197234

S35F1
Solute carrier family 35 member F1

1

2

High-throughput

0.407

High

1197259

S35F5
Solute carrier family 35 member F5

1

2

High-throughput

0.407

High

1197269

S1PR3
Sphingosine 1-phosphate receptor 3

1

5

High-throughput

0.407

High

1197237

STYK1
Tyrosine-protein kinase STYK1

3

0

High-throughput

0.349

High

229187

B3GT2
Beta-1,3-galactosyltransferase 2

3

0

High-throughput

0.347

High

1197292

SIAT9
Lactosylceramide alpha-2,3-sialyltransferase

3

0

High-throughput

0.347

High

1197279

YIPF3
Protein YIPF3

2

0

High-throughput

0.328

High

1197284

TNR19
Tumor necrosis factor receptor superfamily member 19

2

0

High-throughput

0.328

High

230967

TYOBP
TYRO protein tyrosine kinase-binding protein

2

0

High-throughput

0.313

High

1197262

FUCT1
GDP-fucose transporter 1

2

0

High-throughput

0.313

High

1197274

ABHEA
Protein ABHD14A

2

0

High-throughput

0.313

High

316505

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

0

High-throughput

0.279

Low

351757

SG1D2
Secretoglobin family 1D member 2

1

0

High-throughput

0.279

Low

380438

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

0

High-throughput

0.279

Low

387528

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.279

Low

387653

APOC3
Apolipoprotein C-III

1

0

High-throughput

0.279

Low

692204

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

1

0

High-throughput

0.279

Low

933972

APOC4
Apolipoprotein C-IV

1

0

High-throughput

0.279

Low

1024374

S25A3
Solute carrier family 25 member 3

1

0

High-throughput

0.279

Low

1197241

TMCO3
Transmembrane and coiled-coil domain-containing protein 3

1

0

High-throughput

0.279

Low

1197247

ANR46
Ankyrin repeat domain-containing protein 46

1

0

High-throughput

0.279

Low

1197253

M4A15
Membrane-spanning 4-domains subfamily A member 15

1

0

High-throughput

0.279

Low

1197255

OR4N2
Olfactory receptor 4N2

1

0

High-throughput

0.279

Low

1197256

OR6T1
Olfactory receptor 6T1

1

0

High-throughput

0.279

Low

1197264

VOPP1
WW domain binding protein VOPP1

1

0

High-throughput

0.279

Low

1197266

PLPR2
Phospholipid phosphatase-related protein type 2

1

0

High-throughput

0.279

Low

1197280

GPR88
G protein-coupled receptor 88

1

0

High-throughput

0.279

Low

1197289

P2RX2
P2X purinoceptor 2

1

0

High-throughput

0.279

Low

1197290

TSN16
Tetraspanin-16

1

0

High-throughput

0.279

Low

1197291

TNF18
Tumor necrosis factor ligand superfamily member 18

1

0

High-throughput

0.279

Low

49449

TM223
Transmembrane protein 223

1

0

High-throughput

0.269

Low

218263

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

378111

TNFA
Tumor necrosis factor

1

0

High-throughput

0.249

Low

969622

RS15A
Small ribosomal subunit protein uS8

1

0

Small-scale

0.249

Low

1136094

PAF15
PCNA-associated factor

1

0

Small-scale

0.249

Low

1155148

EREP1
Endosomal transmembrane epsin interactor 1

1

0

High-throughput

0.249

Low

1197189

SIM43
Small integral membrane protein 43

1

0

High-throughput

0.249

Low

1197239

CH074
Uncharacterized protein C8orf74

1

0

High-throughput

0.249

Low

1197254

DAAF3
Dynein axonemal assembly factor 3

1

0

Small-scale

0.249

Low

1197278

TRIM4
E3 ubiquitin-protein ligase TRIM4

1

0

Small-scale

0.249

Low

1197285

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low

1197286

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

907240

ARSL
Arylsulfatase L

1

0

High-throughput

0.238

Low

351224

MOT3
Monocarboxylate transporter 3

1

0

High-throughput

0.232

Low

574100

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

0

High-throughput

0.232

Low

834977

S19A1
Reduced folate transporter

1

0

High-throughput

0.232

Low

1131538

MFS10
Major facilitator superfamily domain-containing protein 10

1

0

High-throughput

0.232

Low

1197236

K0930
Uncharacterized protein KIAA0930

1

0

High-throughput

0.232

Low

1197238

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.232

Low

1197246

S47A2
Multidrug and toxin extrusion protein 2

1

0

High-throughput

0.232

Low

1197251

S35F3
Solute carrier family 35 member F3

1

0

High-throughput

0.232

Low

1197260

S13A3
Na(+)/dicarboxylate cotransporter 3

1

0

High-throughput

0.232

Low

1197267

B3A4
Anion exchange protein 4

1

0

High-throughput

0.232

Low

1197268

S26A8
Testis anion transporter 1

1

0

High-throughput

0.232

Low

1197277

S12A9
Solute carrier family 12 member 9

1

0

High-throughput

0.232

Low

1197281

ANKH
Mineralization regulator ANKH

1

0

High-throughput

0.232

Low

1197288

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025