Protein: SIX3
Homeobox protein SIX3 (Sine oculis homeobox homolog 3)

Gene: SIX3
Organism: Homo sapiens
Interactions: 16
UniProt ID: O95343

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001222 - transcription corepressor binding
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

333891

SIX6
Homeobox protein SIX6

1

20

High-throughput

0.691

High

333901

NR4A3
Nuclear receptor subfamily 4 group A member 3

3

7

Small-scale

0.681

High

333893

PAX6
Paired box protein Pax-6

1

14

Small-scale

0.647

High

164501

TNPO2
Transportin-2

1

1

High-throughput

0.536

High

333899

AHNK2
Protein AHNAK2

1

1

High-throughput

0.536

High

333895

TLE1
Transducin-like enhancer protein 1

1

20

Small-scale

0.527

High

333896

TLE5
TLE family member 5

1

19

Small-scale

0.527

High

284265

GEMI
Geminin

1

2

Small-scale

0.501

High

273034

CLU
Clustered mitochondria protein homolog

1

1

High-throughput

0.489

High

333894

ACTA
Actin, aortic smooth muscle

1

2

High-throughput

0.489

High

333900

PALS1
Protein PALS1

1

2

High-throughput

0.489

High

333898

OTUD3
OTU domain-containing protein 3

1

0

Small-scale

0.480

High

333892

TRI27
Zinc finger protein RFP

1

2

Small-scale

0.479

High

333897

MTA1
Metastasis-associated protein MTA1

1

6

Small-scale

0.479

High

333903

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

2

Small-scale

0.479

High

333902

COR2A
Coronin-2A

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025