Protein: CLU
Clustered mitochondria protein homolog

Gene: CLU, CLUH
Organism: Homo sapiens
Interactions: 108
UniProt ID: O75153

Gene Ontology (top 5):
GO:0003729 - mRNA binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0007005 - mitochondrion organization
GO:0048312 - intracellular distribution of mitochondria

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

273088

WDR90
WD repeat-containing protein 90

3

5

High-throughput

0.667

High

273121

WDR37
WD repeat-containing protein 37

3

5

High-throughput

0.667

High

273101

CLPB
Mitochondrial disaggregase

3

3

High-throughput

0.662

High

273071

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

4

0

High-throughput

0.661

High

273068

FTM
Protein fantom

3

2

High-throughput

0.650

High

273036

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

3

7

High-throughput

0.640

High

273033

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

3

0

High-throughput

0.638

High

273037

MOS
Proto-oncogene serine/threonine-protein kinase mos

3

0

High-throughput

0.638

High

273080

DC4L2
DDB1- and CUL4-associated factor 4-like protein 2

4

2

Small-scale

0.633

High

273085

COA8
Cytochrome c oxidase assembly factor 8

3

0

High-throughput

0.629

High

273058

MPPA
Mitochondrial-processing peptidase subunit alpha

2

4

High-throughput

0.628

High

273069

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

2

1

High-throughput

0.628

High

273098

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

2

8

High-throughput

0.628

High

273029

CLU
Clustered mitochondria protein homolog

1

18

High-throughput

0.618

High

273049

HSPA9
Stress-70 protein, mitochondrial

1

13

High-throughput

0.618

High

273094

DNJC7
DnaJ homolog subfamily C member 7

1

9

High-throughput

0.618

High

273039

P53
Cellular tumor antigen p53

2

1

High-throughput

0.611

High

273076

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

2

High-throughput

0.611

High

273091

SPAG5
Sperm-associated antigen 5

2

4

High-throughput

0.611

High

273124

SKAP
Small kinetochore-associated protein

2

1

High-throughput

0.611

High

273083

HDA11
Histone deacetylase 11

3

5

High-throughput

0.604

High

273045

HEMH
Ferrochelatase, mitochondrial

2

0

High-throughput

0.602

High

273084

SYMM
Methionine--tRNA ligase, mitochondrial

2

2

High-throughput

0.601

High

273095

KLDC3
Kelch domain-containing protein 3

2

2

High-throughput

0.601

High

273116

NPS3A
Protein NipSnap homolog 3A

2

1

High-throughput

0.601

High

273103

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

2

0

High-throughput

0.585

High

67161

ZAR1L
Protein ZAR1-like

2

0

High-throughput

0.576

High

273089

MCEE
Methylmalonyl-CoA epimerase, mitochondrial

2

0

High-throughput

0.576

High

273062

F263
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

2

1

High-throughput

0.574

High

273081

DCAF4
DDB1- and CUL4-associated factor 4

2

2

High-throughput

0.574

High

273086

THOC3
THO complex subunit 3

2

4

High-throughput

0.574

High

273097

TEKT3
Tektin-3

2

1

High-throughput

0.574

High

273052

PER3
Period circadian protein homolog 3

1

3

High-throughput

0.536

High

273064

ACSM3
Acyl-coenzyme A synthetase ACSM3, mitochondrial

1

1

High-throughput

0.536

High

273096

NPS3B
Protein NipSnap homolog 3B

1

1

High-throughput

0.536

High

273119

TPC2L
Trafficking protein particle complex subunit 2-like protein

1

2

High-throughput

0.536

High

273125

RM42
Large ribosomal subunit protein mL42

1

1

High-throughput

0.536

High

273077

PARP9
Protein mono-ADP-ribosyltransferase PARP9

1

3

High-throughput

0.515

High

273120

MTUS1
Microtubule-associated tumor suppressor 1

1

3

High-throughput

0.515

High

273051

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.513

High

273123

CIA30
Complex I intermediate-associated protein 30, mitochondrial

1

0

High-throughput

0.513

High

273034

SIX3
Homeobox protein SIX3

1

1

High-throughput

0.489

High

273035

SIX6
Homeobox protein SIX6

1

4

High-throughput

0.489

High

273087

MRP9
ATP-binding cassette sub-family C member 12

1

1

High-throughput

0.489

High

273106

MAGIX
PDZ domain-containing protein MAGIX

1

3

High-throughput

0.489

High

273118

FOXD3
Forkhead box protein D3

1

2

High-throughput

0.489

High

240263

PRKN
E3 ubiquitin-protein ligase parkin

1

14

High-throughput

0.479

High

273031

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

273038

NTRK1
High affinity nerve growth factor receptor

1

8

High-throughput

0.479

High

273040

K2C8
Keratin, type II cytoskeletal 8

1

5

High-throughput

0.479

High

273042

DESP
Desmoplakin

1

6

High-throughput

0.479

High

273050

CCNF
Cyclin-F

1

9

High-throughput

0.479

High

273057

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

273059

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

273072

SYNE3
Nesprin-3

1

2

High-throughput

0.479

High

273073

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.479

High

273074

MOB3C
MOB kinase activator 3C

1

2

High-throughput

0.479

High

273093

DNJC2
DnaJ homolog subfamily C member 2

1

3

High-throughput

0.479

High

273100

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

3

High-throughput

0.479

High

273102

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

6

Small-scale

0.479

High

273105

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.479

High

273107

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

273108

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

273111

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

273117

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

61369

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

245388

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

0

High-throughput

0.458

High

273032

EPM2A
Laforin

1

0

High-throughput

0.458

High

273041

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

273055

RL27
Large ribosomal subunit protein eL27

1

0

High-throughput

0.458

High

273061

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.458

High

273070

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.458

High

273075

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

273082

MCUR1
Mitochondrial calcium uniporter regulator 1

1

0

High-throughput

0.458

High

273090

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.458

High

273092

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.458

High

273053

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

4

High-throughput

0.445

High

273063

DC4L1
DDB1- and CUL4-associated factor 4-like protein 1

1

2

High-throughput

0.445

High

273065

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.445

High

273115

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

1

High-throughput

0.445

High

104941

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

262456

MCE1
mRNA-capping enzyme

1

4

High-throughput

0.437

High

273043

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

273044

FGFR3
Fibroblast growth factor receptor 3

1

11

High-throughput

0.437

High

273047

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

273048

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

273054

DJB13
DnaJ homolog subfamily B member 13

1

4

High-throughput

0.437

High

273056

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.437

High

273060

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.437

High

273104

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

4

High-throughput

0.437

High

273114

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.437

High

273109

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

0

High-throughput

0.426

High

273112

RM16
Large ribosomal subunit protein uL16m

1

0

High-throughput

0.426

High

273113

CELR3
Cadherin EGF LAG seven-pass G-type receptor 3

1

1

Small-scale

0.417

High

273067

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.407

High

273079

ZN321
Putative protein ZNF321

1

2

High-throughput

0.407

High

273099

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.407

High

190694

MPPD1
Metallophosphoesterase domain-containing protein 1

4

0

High-throughput

0.360

High

179430

ARPC3
Actin-related protein 2/3 complex subunit 3

3

0

High-throughput

0.347

High

165751

PAHX
Phytanoyl-CoA dioxygenase, peroxisomal

1

0

High-throughput

0.279

Low

261460

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.279

Low

273030

NPHP4
Nephrocystin-4

1

0

High-throughput

0.249

Low

273046

HAP40
40-kDa huntingtin-associated protein

1

0

High-throughput

0.249

Low

273066

GKAP1
G kinase-anchoring protein 1

1

0

High-throughput

0.249

Low

273078

RP25L
Ribonuclease P protein subunit p25-like protein

1

0

High-throughput

0.249

Low

273122

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

273110

IFT57
Intraflagellar transport protein 57 homolog

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025