Protein: GEMI
Geminin

Gene: GEMI, GMNN
Organism: Homo sapiens
Interactions: 115
UniProt ID: O75496

Gene Ontology (top 5):
GO:0003682 - chromatin binding
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

284348

CDT1
DNA replication factor Cdt1

24

3

Small-scale

0.992

High

94478

MCIN
Multicilin

3

2

Small-scale

0.871

High

284280

CDK2
Cyclin-dependent kinase 2

4

2

High-throughput

0.699

High

284337

ZN439
Zinc finger protein 439

4

1

High-throughput

0.698

High

284313

TFDP1
Transcription factor Dp-1

3

2

High-throughput

0.675

High

284278

CCNA2
Cyclin-A2

4

0

High-throughput

0.670

High

284303

CDK3
Cyclin-dependent kinase 3

3

2

High-throughput

0.667

High

284272

HSP7C
Heat shock cognate 71 kDa protein

3

1

High-throughput

0.662

High

284362

FZR1
Fizzy-related protein homolog

3

2

Small-scale

0.660

High

284269

CDK1
Cyclin-dependent kinase 1

3

2

High-throughput

0.650

High

284307

CDC20
Cell division cycle protein 20 homolog

3

2

Small-scale

0.646

High

284311

MTMR1
Phosphatidylinositol-3-phosphate phosphatase MTMR1

3

0

High-throughput

0.646

High

284294

CDN2A
Cyclin-dependent kinase inhibitor 2A

2

1

High-throughput

0.633

High

69749

ZN785
Zinc finger protein 785

2

1

High-throughput

0.628

High

186491

TRI18
E3 ubiquitin-protein ligase Midline-1

2

2

High-throughput

0.628

High

276257

HMMR
Hyaluronan mediated motility receptor

2

1

High-throughput

0.628

High

284290

CKS2
Cyclin-dependent kinases regulatory subunit 2

2

1

High-throughput

0.628

High

284299

CKS1
Cyclin-dependent kinases regulatory subunit 1

2

1

High-throughput

0.628

High

284317

E2F5
Transcription factor E2F5

2

1

High-throughput

0.628

High

284318

E2F4
Transcription factor E2F4

2

1

High-throughput

0.628

High

284359

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

2

High-throughput

0.628

High

284324

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

1

High-throughput

0.606

High

284266

BAG4
BAG family molecular chaperone regulator 4

2

0

High-throughput

0.602

High

284287

TYK2
Non-receptor tyrosine-protein kinase TYK2

2

0

High-throughput

0.602

High

284308

SKP2
S-phase kinase-associated protein 2

2

0

High-throughput

0.602

High

284310

TARB1
tRNA

2

0

High-throughput

0.602

High

284319

CTC1
CST complex subunit CTC1

2

0

High-throughput

0.602

High

284321

KLH22
Kelch-like protein 22

2

0

High-throughput

0.602

High

284325

MSL1
Male-specific lethal 1 homolog

2

0

High-throughput

0.602

High

284329

NPHP3
Nephrocystin-3

2

0

High-throughput

0.602

High

284332

TF2LY
Homeobox protein TGIF2LY

2

0

High-throughput

0.602

High

284339

CERK1
Ceramide kinase

2

0

High-throughput

0.602

High

284349

FA83D
Protein FAM83D

2

0

High-throughput

0.602

High

284352

STN1
CST complex subunit STN1

2

0

High-throughput

0.602

High

284355

MYO5C
Unconventional myosin-Vc

2

0

High-throughput

0.602

High

284262

GEMI
Geminin

1

2

High-throughput

0.590

High

284336

PNKD
Probable thioesterase PNKD

2

0

High-throughput

0.585

High

284277

ZN250
Zinc finger protein 250

2

0

High-throughput

0.580

High

284306

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

0

High-throughput

0.580

High

284331

SAPC2
Suppressor APC domain-containing protein 2

2

0

High-throughput

0.580

High

284338

LNX1
E3 ubiquitin-protein ligase LNX

2

0

High-throughput

0.580

High

284347

GLIS2
Zinc finger protein GLIS2

2

0

High-throughput

0.580

High

284297

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

1

Small-scale

0.561

High

284289

HXC9
Homeobox protein Hox-C9

1

8

Small-scale

0.554

High

169854

AURKA
Aurora kinase A

1

0

Small-scale

0.537

High

284346

REPI1
DNA-binding protein REPIN1

1

0

Small-scale

0.537

High

284298

HSP72
Heat shock-related 70 kDa protein 2

1

1

High-throughput

0.536

High

284315

CASP8
Caspase-8

1

1

High-throughput

0.536

High

284335

SIX5
Homeobox protein SIX5

1

1

High-throughput

0.536

High

284279

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

1

0

High-throughput

0.518

High

284283

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

0

High-throughput

0.518

High

284291

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.513

High

284314

MCM6
DNA replication licensing factor MCM6

1

0

High-throughput

0.513

High

227279

SPOP
Speckle-type POZ protein

1

0

Small-scale

0.513

High

284267

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

284270

CLCB
Clathrin light chain B

1

0

High-throughput

0.513

High

284274

TRI27
Zinc finger protein RFP

1

0

High-throughput

0.513

High

284281

S100P
Protein S100-P

1

0

High-throughput

0.513

High

284309

ATM
Serine-protein kinase ATM

1

0

High-throughput

0.513

High

284323

HERC4
Probable E3 ubiquitin-protein ligase HERC4

1

0

High-throughput

0.513

High

284327

TPGS1
Tubulin polyglutamylase complex subunit 1

1

0

High-throughput

0.513

High

284328

SPT6H
Transcription elongation factor SPT6

1

0

High-throughput

0.513

High

284330

TEDC1
Tubulin epsilon and delta complex protein 1

1

0

High-throughput

0.513

High

284345

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.513

High

284351

PIF1
ATP-dependent DNA helicase PIF1

1

0

High-throughput

0.513

High

284353

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

0

High-throughput

0.513

High

284264

KAT7
Histone acetyltransferase KAT7

1

1

Small-scale

0.501

High

284265

SIX3
Homeobox protein SIX3

1

2

Small-scale

0.501

High

284276

HXB1
Homeobox protein Hox-B1

1

6

Small-scale

0.501

High

284285

HXD10
Homeobox protein Hox-D10

1

8

Small-scale

0.501

High

284286

MSX1
Homeobox protein MSX-1

1

4

Small-scale

0.501

High

284293

CASP3
Caspase-3

1

1

Small-scale

0.501

High

284302

CSK21
Casein kinase II subunit alpha

1

2

Small-scale

0.501

High

284305

PO5F1
POU domain, class 5, transcription factor 1

1

1

Small-scale

0.501

High

284344

RING2
E3 ubiquitin-protein ligase RING2

1

1

Small-scale

0.501

High

284282

PAX6
Paired box protein Pax-6

1

0

Small-scale

0.480

High

284300

ISL1
Insulin gene enhancer protein ISL-1

1

0

Small-scale

0.480

High

284360

FBX5
F-box only protein 5

1

0

Small-scale

0.479

High

284263

RNF8
E3 ubiquitin-protein ligase RNF8

1

1

Small-scale

0.479

High

284292

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

284296

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

1

Small-scale

0.479

High

284316

CDK10
Cyclin-dependent kinase 10

1

3

High-throughput

0.479

High

284341

ASB11
Ankyrin repeat and SOCS box protein 11

1

1

High-throughput

0.479

High

284342

HDA11
Histone deacetylase 11

1

1

Small-scale

0.479

High

284275

NCF1
Neutrophil cytosol factor 1

1

0

Small-scale

0.460

High

188132

HDAC3
Histone deacetylase 3

1

0

Small-scale

0.458

High

284268

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

284273

CADH1
Cadherin-1

1

0

Small-scale

0.458

High

284288

CDC27
Cell division cycle protein 27 homolog

1

0

Small-scale

0.458

High

284301

WDR5
WD repeat-containing protein 5

1

0

Small-scale

0.458

High

284304

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

284312

CUL3
Cullin-3

1

0

High-throughput

0.458

High

284326

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

284343

KKCC2
Calcium/calmodulin-dependent protein kinase kinase 2

1

0

High-throughput

0.458

High

284350

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

284358

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

1

0

Small-scale

0.458

High

284340

CE192
Centrosomal protein of 192 kDa

1

1

High-throughput

0.445

High

284354

Q9HCK3
KIAA1569 protein

1

1

High-throughput

0.437

High

133830

FOXN3
Forkhead box protein N3

1

0

High-throughput

0.426

High

284295

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

284333

CC146
Coiled-coil domain-containing protein 146

7

0

High-throughput

0.391

High

284320

CB068
UPF0561 protein C2orf68

3

0

High-throughput

0.347

High

284322

RUN3A
RUN domain-containing protein 3A

2

0

High-throughput

0.328

High

284361

HECD1
E3 ubiquitin-protein ligase HECTD1

2

0

High-throughput

0.328

High

49147

POTB3
POTE ankyrin domain family member B3

2

0

High-throughput

0.288

High

207774

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

1

0

High-throughput

0.279

Low

252738

AP180
Clathrin coat assembly protein AP180

1

0

High-throughput

0.279

Low

284284

CALX
Calnexin

1

0

High-throughput

0.279

Low

284334

FAM9C
Protein FAM9C

1

0

High-throughput

0.279

Low

284357

HPBP1
Hsp70-binding protein 1

1

0

High-throughput

0.279

Low

284363

ANGP4
Angiopoietin-4

1

0

High-throughput

0.279

Low

284364

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.279

Low

284356

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.249

Low

284271

CT456
Cancer/testis antigen family 45 member A6

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025