Protein: HEP2
Heparin cofactor 2 (Heparin cofactor II) (HC-II) (Protease inhibitor leuserpin-2) (HLS2) (Serpin D1)

Gene: HEP2, SERPIND1
Organism: Homo sapiens
Interactions: 18
UniProt ID: P05546

Gene Ontology (top 5):
GO:0004866 - endopeptidase inhibitor activity
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005788 - endoplasmic reticulum lumen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

210682

KLK10
Kallikrein-10

1

20

High-throughput

0.691

High

421298

A4
Amyloid-beta precursor protein

2

2

High-throughput

0.602

High

366086

THRB
Prothrombin

1

20

Small-scale

0.575

High

379190

IGHG1
Immunoglobulin heavy constant gamma 1

1

1

High-throughput

0.575

High

379607

IGHA1
Immunoglobulin heavy constant alpha 1

1

1

High-throughput

0.575

High

431489

VAT1L
Synaptic vesicle membrane protein VAT-1 homolog-like

2

3

High-throughput

0.558

High

431480

FGF4
Fibroblast growth factor 4

1

1

High-throughput

0.536

High

431481

CFTR
Cystic fibrosis transmembrane conductance regulator

1

7

High-throughput

0.494

High

431483

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

6

High-throughput

0.489

High

431484

RHBL4
Rhomboid-related protein 4

1

5

High-throughput

0.489

High

431487

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

8

High-throughput

0.489

High

431490

PHF11
PHD finger protein 11

1

8

High-throughput

0.489

High

390845

TRFE
Serotransferrin

1

2

High-throughput

0.445

High

431482

LAMB3
Laminin subunit beta-3

1

2

High-throughput

0.445

High

277253

PITX3
Pituitary homeobox 3

1

3

Small-scale

0.437

High

431485

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.437

High

431486

NECD
Necdin

1

1

High-throughput

0.407

High

431488

UCK2
Uridine-cytidine kinase 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025