Protein: UBE2W
Ubiquitin-conjugating enzyme E2 W (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme W) (N-terminal E2 ubiquitin-conjugating enzyme) (EC 2.3.2.25) (N-terminus-conjugating E2) (Ubiquitin carrier protein W) (Ubiquitin-conjugating enzyme 16) (UBC-16) (Ubiquitin-protein ligase W)

Gene: UBE2W
Organism: Homo sapiens
Interactions: 100
UniProt ID: Q96B02

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1383947

CHIP
E3 ubiquitin-protein ligase CHIP

7

14

Small-scale

0.960

High

799378

BRCA1
Breast cancer type 1 susceptibility protein

5

20

Small-scale

0.927

High

647621

UBA1
Ubiquitin-like modifier-activating enzyme 1

5

20

Small-scale

0.919

High

1004943

RNF4
E3 ubiquitin-protein ligase RNF4

4

20

Small-scale

0.893

High

1383934

RN167
E3 ubiquitin-protein ligase RNF167

3

20

Small-scale

0.868

High

1252763

RN111
E3 ubiquitin-protein ligase Arkadia

3

20

High-throughput

0.867

High

1383938

FANCL
E3 ubiquitin-protein ligase FANCL

3

2

Small-scale

0.840

High

1383927

RNF5
E3 ubiquitin-protein ligase RNF5

2

20

High-throughput

0.834

High

1383920

OTUB1
Ubiquitin thioesterase OTUB1

3

9

Small-scale

0.817

High

1383949

RN115
E3 ubiquitin-protein ligase RNF115

2

20

High-throughput

0.817

High

1383945

AMFR
E3 ubiquitin-protein ligase AMFR

2

20

High-throughput

0.815

High

623475

RO52
E3 ubiquitin-protein ligase TRIM21

2

20

Small-scale

0.806

High

1383928

RNF26
E3 ubiquitin-protein ligase RNF26

2

20

High-throughput

0.801

High

1336241

ZNRF1
E3 ubiquitin-protein ligase ZNRF1

2

19

Small-scale

0.800

High

1383933

TRIM2
Tripartite motif-containing protein 2

2

20

Small-scale

0.800

High

1022765

XIAP
E3 ubiquitin-protein ligase XIAP

2

20

Small-scale

0.791

High

1383939

MARH5
E3 ubiquitin-protein ligase MARCHF5

4

7

High-throughput

0.700

High

128512

RN103
E3 ubiquitin-protein ligase RNF103

1

20

High-throughput

0.698

High

186571

TRI18
E3 ubiquitin-protein ligase Midline-1

1

20

High-throughput

0.698

High

208547

PJA2
E3 ubiquitin-protein ligase Praja-2

1

20

High-throughput

0.698

High

244489

MGRN1
E3 ubiquitin-protein ligase MGRN1

1

9

High-throughput

0.698

High

302603

RNF8
E3 ubiquitin-protein ligase RNF8

1

20

High-throughput

0.698

High

322559

RNF37
RING finger protein 37

1

6

High-throughput

0.698

High

340585

CNOT4
CCR4-NOT transcription complex subunit 4

1

11

High-throughput

0.698

High

1093682

MKRN3
E3 ubiquitin-protein ligase makorin-3

1

15

High-throughput

0.698

High

1107446

BIRC2
Baculoviral IAP repeat-containing protein 2

1

20

High-throughput

0.698

High

1243712

RFWD3
E3 ubiquitin-protein ligase RFWD3

1

20

High-throughput

0.698

High

1248433

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

7

High-throughput

0.698

High

1254113

ARK2C
E3 ubiquitin-protein ligase ARK2C

1

20

High-throughput

0.698

High

1294546

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

20

High-throughput

0.698

High

1295523

MIB1
E3 ubiquitin-protein ligase MIB1

1

7

High-throughput

0.698

High

1328512

RNF10
E3 ubiquitin-protein ligase RNF10

1

20

High-throughput

0.698

High

1331905

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

20

High-throughput

0.698

High

1350939

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

20

High-throughput

0.698

High

1357971

RN138
E3 ubiquitin-protein ligase RNF138

1

20

High-throughput

0.698

High

1359343

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

20

High-throughput

0.698

High

1381384

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

20

High-throughput

0.698

High

1382330

RN166
E3 ubiquitin-protein ligase RNF166

1

20

High-throughput

0.698

High

1383918

CHFR
E3 ubiquitin-protein ligase CHFR

1

20

High-throughput

0.698

High

1383919

RN125
E3 ubiquitin-protein ligase RNF125

1

20

High-throughput

0.698

High

1383921

RMD5B
E3 ubiquitin-protein transferase RMND5B

1

7

High-throughput

0.698

High

1383923

BIRC8
Baculoviral IAP repeat-containing protein 8

1

20

High-throughput

0.698

High

1383924

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

8

High-throughput

0.698

High

1383925

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.698

High

1383929

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

20

High-throughput

0.698

High

1383937

TOPRS
E3 ubiquitin-protein ligase Topors

1

6

High-throughput

0.698

High

1383942

RNF14
E3 ubiquitin-protein ligase RNF14

1

20

High-throughput

0.698

High

1383946

RN150
RING finger protein 150

1

20

High-throughput

0.698

High

1383948

TRI35
E3 ubiquitin-protein ligase TRIM35

1

20

High-throughput

0.698

High

1383950

RN114
E3 ubiquitin-protein ligase RNF114

1

20

High-throughput

0.698

High

1383951

TRI17
E3 ubiquitin-protein ligase TRIM17

1

20

High-throughput

0.698

High

1025404

CDK6
Cyclin-dependent kinase 6

3

2

High-throughput

0.667

High

285405

EED
Polycomb protein EED

1

7

High-throughput

0.656

High

1220718

RN123
E3 ubiquitin-protein ligase RNF123

1

8

High-throughput

0.656

High

1383943

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

15

High-throughput

0.656

High

1383926

BARD1
BRCA1-associated RING domain protein 1

3

9

Small-scale

0.655

High

279064

TRIM3
Tripartite motif-containing protein 3

1

20

Small-scale

0.647

High

783365

TRI23
E3 ubiquitin-protein ligase TRIM23

1

9

Small-scale

0.647

High

1383915

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

16

Small-scale

0.647

High

1383917

RNF31
E3 ubiquitin-protein ligase RNF31

1

20

Small-scale

0.647

High

1383932

TRIM5
Tripartite motif-containing protein 5

1

20

Small-scale

0.647

High

1383922

RN185
E3 ubiquitin-protein ligase RNF185

1

20

High-throughput

0.625

High

651398

CBL
E3 ubiquitin-protein ligase CBL

1

12

Small-scale

0.621

High

1340066

ZNRF2
E3 ubiquitin-protein ligase ZNRF2

1

19

Small-scale

0.621

High

983926

RBX1
E3 ubiquitin-protein ligase RBX1

1

20

Small-scale

0.618

High

1383944

HERC5
E3 ISG15--protein ligase HERC5

1

20

Small-scale

0.618

High

220790

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

2

0

High-throughput

0.613

High

1217713

RN220
E3 ubiquitin-protein ligase RNF220

1

8

High-throughput

0.590

High

530190

TAU
Microtubule-associated protein tau

2

3

Small-scale

0.585

High

1383935

ROP1A
Ropporin-1A

1

1

High-throughput

0.573

High

1310695

TRI59
Tripartite motif-containing protein 59

1

20

High-throughput

0.555

High

572113

TRI27
Zinc finger protein RFP

1

20

High-throughput

0.541

High

838913

AK1C3
Aldo-keto reductase family 1 member C3

1

1

High-throughput

0.541

High

1098827

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

14

High-throughput

0.541

High

1288117

MARH3
E3 ubiquitin-protein ligase MARCHF3

1

20

High-throughput

0.541

High

1289217

CAPS2
Calcium-dependent secretion activator 2

1

6

High-throughput

0.541

High

1331290

RN152
E3 ubiquitin-protein ligase RNF152

1

20

High-throughput

0.541

High

1383930

TRI31
E3 ubiquitin-protein ligase TRIM31

1

20

High-throughput

0.541

High

1383936

TRI39
E3 ubiquitin-protein ligase TRIM39

1

20

High-throughput

0.541

High

1383940

BFAR
Bifunctional apoptosis regulator

1

20

High-throughput

0.541

High

246307

MARH6
E3 ubiquitin-protein ligase MARCHF6

1

20

High-throughput

0.536

High

1307254

TF2LX
Homeobox protein TGIF2LX

1

1

High-throughput

0.536

High

1330772

UBR7
Putative E3 ubiquitin-protein ligase UBR7

1

1

High-throughput

0.536

High

912100

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

Small-scale

0.527

High

1330044

USBP1
Harmonin-binding protein USHBP1

1

1

High-throughput

0.523

High

621706

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.518

High

1313673

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.513

High

791614

SYUA
Alpha-synuclein

1

1

Small-scale

0.501

High

927091

ATX3
Ataxin-3

1

1

Small-scale

0.501

High

1383931

TRIM7
E3 ubiquitin-protein ligase TRIM7

1

20

Small-scale

0.501

High

876109

TCPE
T-complex protein 1 subunit epsilon

1

0

High-throughput

0.493

High

1383941

DNM3B
DNA

1

0

High-throughput

0.486

High

964547

UFM1
Ubiquitin-fold modifier 1

1

6

High-throughput

0.481

High

1383916

RN183
E3 ubiquitin-protein ligase RNF183

1

1

High-throughput

0.481

High

319964

UFL1
E3 UFM1-protein ligase 1

1

6

High-throughput

0.457

High

972742

RS23
Small ribosomal subunit protein uS12

1

1

High-throughput

0.457

High

982509

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.457

High

1383952

SNURF
SNRPN upstream reading frame protein

1

4

High-throughput

0.457

High

387137

TNNC2
Troponin C, skeletal muscle

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025