Protein: TNF12
Tumor necrosis factor ligand superfamily member 12 (APO3 ligand) (TNF-related weak inducer of apoptosis) (TWEAK) [Cleaved into: Tumor necrosis factor ligand superfamily member 12, membrane form; Tumor necrosis factor ligand superfamily member 12, secreted form]

Gene: TNF12, TNFSF12
Organism: Homo sapiens
Interactions: 31
UniProt ID: O43508

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001938 - positive regulation of endothelial cell proliferation
GO:0005102 - signaling receptor binding
GO:0005125 - cytokine activity
GO:0005164 - tumor necrosis factor receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

219403

DDIT3
DNA damage-inducible transcript 3 protein

3

1

High-throughput

0.597

High

219424

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

0

Small-scale

0.586

High

219421

TNR12
Tumor necrosis factor receptor superfamily member 12A

2

0

Small-scale

0.585

High

219407

TRAF2
TNF receptor-associated factor 2

1

0

Small-scale

0.513

High

219408

BIRC2
Baculoviral IAP repeat-containing protein 2

1

0

Small-scale

0.513

High

219400

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.493

High

219401

CDK1
Cyclin-dependent kinase 1

1

0

High-throughput

0.493

High

219423

DICER
Endoribonuclease Dicer

1

0

Small-scale

0.484

High

219399

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.460

High

213296

ADCY6
Adenylate cyclase type 6

1

0

High-throughput

0.458

High

219402

LYN
Tyrosine-protein kinase Lyn

1

0

Small-scale

0.458

High

219404

CLCN3
H(+)/Cl(-) exchange transporter 3

1

0

High-throughput

0.458

High

219406

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

219409

IMB1
Importin subunit beta-1

1

0

High-throughput

0.458

High

219417

FAM3C
Protein FAM3C

1

0

High-throughput

0.458

High

219420

TRPM3
Transient receptor potential cation channel subfamily M member 3

1

0

High-throughput

0.458

High

219422

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

1

0

High-throughput

0.458

High

219426

ZNT1
Proton-coupled zinc antiporter SLC30A1

1

0

High-throughput

0.458

High

219397

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

2

0

High-throughput

0.316

High

219418

OTUB1
Ubiquitin thioesterase OTUB1

1

0

Small-scale

0.279

Low

219398

NRDC
Nardilysin

1

0

High-throughput

0.249

Low

219405

RRP1
Ribosomal RNA processing protein 1 homolog A

1

0

High-throughput

0.249

Low

219410

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

219411

TTI2
TELO2-interacting protein 2

1

0

High-throughput

0.249

Low

219412

DJC14
DnaJ homolog subfamily C member 14

1

0

High-throughput

0.249

Low

219413

RBM23
Probable RNA-binding protein 23

1

0

High-throughput

0.249

Low

219414

NOP9
Nucleolar protein 9

1

0

High-throughput

0.249

Low

219415

ARL10
ADP-ribosylation factor-like protein 10

1

0

High-throughput

0.249

Low

219416

CC71L
Coiled-coil domain-containing protein 71L

1

0

High-throughput

0.249

Low

219419

KLDC3
Kelch domain-containing protein 3

1

0

High-throughput

0.249

Low

219425

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025