Protein: CLCN3
H(+)/Cl(-) exchange transporter 3 (Chloride channel protein 3) (ClC-3) (Chloride transporter ClC-3)

Gene: CLCN3
Organism: Homo sapiens
Interactions: 59
UniProt ID: P51790

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005247 - voltage-gated chloride channel activity
GO:0005254 - chloride channel activity
GO:0005524 - ATP binding
GO:0005765 - lysosomal membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

907702

CLCN5
H(+)/Cl(-) exchange transporter 5

1

5

High-throughput

0.691

High

609627

LEG3
Galectin-3

4

9

High-throughput

0.691

High

907729

TMM9B
Transmembrane protein 9B

4

6

High-throughput

0.691

High

127302

LEG8
Galectin-8

3

9

High-throughput

0.667

High

907701

CLCN3
H(+)/Cl(-) exchange transporter 3

1

5

Small-scale

0.665

High

271596

ICOSL
ICOS ligand

1

0

High-throughput

0.656

High

907732

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

3

6

High-throughput

0.650

High

125334

LEG9
Galectin-9

4

9

High-throughput

0.630

High

332624

LYPD3
Ly6/PLAUR domain-containing protein 3

2

1

High-throughput

0.611

High

907721

TPC2
Two pore channel protein 2

2

0

High-throughput

0.602

High

907733

GGA1
ADP-ribosylation factor-binding protein GGA1

2

0

High-throughput

0.602

High

907714

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

1

1

Small-scale

0.578

High

907716

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.553

High

563453

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

Small-scale

0.536

High

248464

O10H2
Olfactory receptor 10H2

1

1

High-throughput

0.536

High

295569

CIB2
Calcium and integrin-binding family member 2

1

2

High-throughput

0.536

High

719768

V2R
Vasopressin V2 receptor

1

1

High-throughput

0.536

High

907703

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

1

High-throughput

0.536

High

907705

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

1

High-throughput

0.536

High

907707

AVR2B
Activin receptor type-2B

1

1

High-throughput

0.536

High

907713

TTMP
TPA-induced transmembrane protein

1

1

High-throughput

0.536

High

907718

CNGA4
Cyclic nucleotide-gated channel alpha-4

1

1

High-throughput

0.536

High

907734

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.536

High

907735

PCDB7
Protocadherin beta-7

1

1

High-throughput

0.536

High

907736

PCDB3
Protocadherin beta-3

1

2

High-throughput

0.536

High

162810

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

1

Small-scale

0.527

High

907728

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

1

Small-scale

0.527

High

178744

SCAM1
Secretory carrier-associated membrane protein 1

1

0

High-throughput

0.513

High

547315

CP19A
Aromatase

1

0

High-throughput

0.513

High

907704

ACHD
Acetylcholine receptor subunit delta

1

0

High-throughput

0.513

High

907719

TM116
Transmembrane protein 116

1

0

High-throughput

0.513

High

907720

OR4N2
Olfactory receptor 4N2

1

0

High-throughput

0.513

High

907722

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.513

High

907737

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.513

High

907726

DNJC5
DnaJ homolog subfamily C member 5

1

1

High-throughput

0.501

High

907708

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

1

High-throughput

0.489

High

907710

LEG9B
Galectin-9B

1

9

High-throughput

0.489

High

907725

FEM1A
Protein fem-1 homolog A

1

1

High-throughput

0.489

High

507703

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.479

High

901134

RAB7A
Ras-related protein Rab-7a

1

5

High-throughput

0.479

High

907724

RB39B
Ras-related protein Rab-39B

1

2

High-throughput

0.479

High

907709

H2B2E
Histone H2B type 2-E

1

1

High-throughput

0.470

High

219404

TNF12
Tumor necrosis factor ligand superfamily member 12

1

0

High-throughput

0.458

High

651231

CBL
E3 ubiquitin-protein ligase CBL

1

0

High-throughput

0.458

High

877069

KC1D
Casein kinase I isoform delta

1

0

High-throughput

0.458

High

351883

S1PR4
Sphingosine 1-phosphate receptor 4

1

1

High-throughput

0.445

High

704000

5HT1E
5-hydroxytryptamine receptor 1E

1

1

High-throughput

0.445

High

907706

MTAP
S-methyl-5'-thioadenosine phosphorylase

1

2

High-throughput

0.437

High

907717

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.426

High

907715

KLH10
Kelch-like protein 10

1

1

High-throughput

0.407

High

415444

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.282

High

66430

ASB14
Ankyrin repeat and SOCS box protein 14

1

0

High-throughput

0.279

Low

907727

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.279

Low

907730

CP26B
Cytochrome P450 26B1

1

0

High-throughput

0.279

Low

907711

MOGT2
2-acylglycerol O-acyltransferase 2

1

0

High-throughput

0.269

Low

907731

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.269

Low

907712

LARP7
La-related protein 7

1

0

High-throughput

0.249

Low

907723

UQCC5
Ubiquinol-cytochrome c reductase complex assembly factor 5

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025