Protein: DHB3
17-beta-hydroxysteroid dehydrogenase type 3 (17-beta-HSD 3) (Estradiol 17-beta-dehydrogenase 2) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 12C member 2) (Testicular 17-beta-hydroxysteroid dehydrogenase) (Testosterone 17-beta-dehydrogenase 3) (EC 1.1.1.64)

Gene: DHB3, HSD17B3
Organism: Homo sapiens
Interactions: 30
UniProt ID: P37058

Gene Ontology (top 5):
GO:0004303 - estradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006694 - steroid biosynthetic process
GO:0006702 - androgen biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

788491

NCS1
Neuronal calcium sensor 1

3

0

High-throughput

0.638

High

506926

POTEI
POTE ankyrin domain family member I

2

2

High-throughput

0.558

High

788490

ACTB
Actin, cytoplasmic 1

2

3

High-throughput

0.558

High

788493

HERC3
Probable E3 ubiquitin-protein ligase HERC3

2

4

High-throughput

0.558

High

224092

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

1

2

High-throughput

0.541

High

578410

BRAF
Serine/threonine-protein kinase B-raf

1

5

High-throughput

0.541

High

788501

RHG07
Rho GTPase-activating protein 7

1

2

High-throughput

0.541

High

507102

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

7

High-throughput

0.536

High

788502

ABCB9
ABC-type oligopeptide transporter ABCB9

1

2

High-throughput

0.536

High

788505

AMFR
E3 ubiquitin-protein ligase AMFR

1

4

High-throughput

0.536

High

764263

CTNA1
Catenin alpha-1

1

0

High-throughput

0.518

High

788495

SMAD2
Mothers against decapentaplegic homolog 2

1

0

High-throughput

0.518

High

788497

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.513

High

788498

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.513

High

410675

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

9

High-throughput

0.494

High

555915

CADH1
Cadherin-1

1

3

High-throughput

0.494

High

788504

MLH3
DNA mismatch repair protein Mlh3

1

1

High-throughput

0.494

High

788492

AHNK
Neuroblast differentiation-associated protein AHNAK

1

1

High-throughput

0.489

High

788496

ACTBL
Beta-actin-like protein 2

1

2

High-throughput

0.489

High

788506

S12A4
Solute carrier family 12 member 4

1

4

High-throughput

0.489

High

788507

MTCH2
Mitochondrial carrier homolog 2

1

3

High-throughput

0.489

High

413321

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

788499

TAXB1
Tax1-binding protein 1

1

1

High-throughput

0.437

High

788489

MLH1
DNA mismatch repair protein Mlh1

1

1

Small-scale

0.417

High

659381

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.282

High

786415

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

0

High-throughput

0.279

Low

788500

PCP2
Purkinje cell protein 2 homolog

1

0

High-throughput

0.279

Low

788503

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.279

Low

539524

PYGB
Glycogen phosphorylase, brain form

1

0

High-throughput

0.249

Low

788494

EEA1
Early endosome antigen 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025