Protein: MLH3
DNA mismatch repair protein Mlh3 (MutL protein homolog 3)

Gene: MLH3
Organism: Homo sapiens
Interactions: 61
UniProt ID: Q9UHC1

Gene Ontology (top 5):
GO:0000795 - synaptonemal complex
GO:0001673 - male germ cell nucleus
GO:0003682 - chromatin binding
GO:0003696 - satellite DNA binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

827512

MLH1
DNA mismatch repair protein Mlh1

6

14

Small-scale

0.948

High

191264

MSH4
MutS protein homolog 4

2

20

Small-scale

0.812

High

210470

MSH5
MutS protein homolog 5

1

20

Small-scale

0.647

High

144147

F16P2
Fructose-1,6-bisphosphatase isozyme 2

1

1

High-throughput

0.541

High

254447

CC14B
Dual specificity protein phosphatase CDC14B

1

2

High-throughput

0.541

High

282994

FRAT2
GSK-3-binding protein FRAT2

1

1

High-throughput

0.541

High

374990

RASH
GTPase HRas

1

1

High-throughput

0.541

High

482557

F16P1
Fructose-1,6-bisphosphatase 1

1

1

High-throughput

0.541

High

654141

XPA
DNA repair protein complementing XP-A cells

1

2

High-throughput

0.541

High

728466

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

High-throughput

0.541

High

977604

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

3

High-throughput

0.541

High

1025906

FANCC
Fanconi anemia group C protein

1

1

High-throughput

0.541

High

1038373

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

3

High-throughput

0.541

High

1120137

CYLC2
Cylicin-2

1

1

High-throughput

0.541

High

1154019

SMAD1
Mothers against decapentaplegic homolog 1

1

1

High-throughput

0.541

High

1366757

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

1

High-throughput

0.541

High

1380879

TRI63
E3 ubiquitin-protein ligase TRIM63

1

3

High-throughput

0.541

High

1419322

TRI55
Tripartite motif-containing protein 55

1

3

High-throughput

0.541

High

1419393

TBD2A
TBC1 domain family member 2A

1

2

High-throughput

0.541

High

1459789

LEF1
Lymphoid enhancer-binding factor 1

1

1

High-throughput

0.541

High

373418

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.536

High

376918

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.518

High

609893

IBP3
Insulin-like growth factor-binding protein 3

1

0

High-throughput

0.518

High

881619

CDK8
Cyclin-dependent kinase 8

1

0

High-throughput

0.518

High

1417008

HEMGN
Hemogen

1

0

High-throughput

0.518

High

1459791

ZN510
Zinc finger protein 510

1

0

High-throughput

0.518

High

1279790

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

1

High-throughput

0.515

High

551321

PCNA
Proliferating cell nuclear antigen

1

5

Small-scale

0.501

High

1459790

EXO1
Exonuclease 1

1

5

Small-scale

0.501

High

261670

CATL2
Cathepsin L2

1

1

High-throughput

0.494

High

421205

ALDOB
Fructose-bisphosphate aldolase B

1

2

High-throughput

0.494

High

635757

RASA1
Ras GTPase-activating protein 1

1

1

High-throughput

0.494

High

788504

DHB3
17-beta-hydroxysteroid dehydrogenase type 3

1

1

High-throughput

0.494

High

943152

STX17
Syntaxin-17

1

1

High-throughput

0.494

High

1120078

BAAT
Bile acid-CoA:amino acid N-acyltransferase

1

1

High-throughput

0.494

High

1312545

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

1

2

High-throughput

0.494

High

1340622

TDRD7
Tudor domain-containing protein 7

1

1

High-throughput

0.494

High

1393186

SFRP2
Secreted frizzled-related protein 2

1

1

High-throughput

0.494

High

1451852

IMPA3
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase

1

0

High-throughput

0.493

High

520430

ANDR
Androgen receptor

1

1

Small-scale

0.481

High

174631

TRI66
Tripartite motif-containing protein 66

1

5

High-throughput

0.479

High

474351

NFIC
Nuclear factor 1 C-type

1

12

High-throughput

0.479

High

1088079

NFIA
Nuclear factor 1 A-type

1

12

High-throughput

0.479

High

1114572

CUL3
Cullin-3

1

3

High-throughput

0.479

High

1133716

NFIX
Nuclear factor 1 X-type

1

12

High-throughput

0.479

High

1314470

SLX4
Structure-specific endonuclease subunit SLX4

1

2

High-throughput

0.479

High

1459792

FAN1
Fanconi-associated nuclease 1

1

6

Small-scale

0.479

High

109530

G5E9A7
DM1 locus, WD repeat containing

1

3

High-throughput

0.470

High

76634

B4DZK1
cDNA FLJ50036, weakly similar to Myosin-11

1

5

High-throughput

0.439

High

1454185

CC180
Coiled-coil domain-containing protein 180

1

5

High-throughput

0.417

High

159406

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

0

High-throughput

0.282

High

702055

TMOD1
Tropomodulin-1

1

0

High-throughput

0.282

High

951502

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.282

High

1214467

TSTD2
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2

1

0

High-throughput

0.282

High

1307670

ZDH17
Palmitoyltransferase ZDHHC17

1

0

High-throughput

0.282

High

1315412

TEFF1
Tomoregulin-1

1

0

High-throughput

0.282

High

1329535

AMPO
Aminopeptidase O

1

0

High-throughput

0.282

High

1392603

MSD3
Myb/SANT-like DNA-binding domain-containing protein 3

1

0

High-throughput

0.282

High

1397762

CANB2
Calcineurin subunit B type 2

1

0

High-throughput

0.282

High

1447940

SIAS
N-acetylneuraminate-9-phosphate synthase

1

0

High-throughput

0.282

High

1141999

EEA1
Early endosome antigen 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025