Protein: PYGB
Glycogen phosphorylase, brain form (EC 2.4.1.1)

Gene: PYGB
Organism: Homo sapiens
Interactions: 108
UniProt ID: P11216

Gene Ontology (top 5):
GO:0005576 - extracellular region
GO:0005737 - cytoplasm
GO:0005980 - glycogen catabolic process
GO:0008184 - glycogen phosphorylase activity
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

446118

PYGL
Glycogen phosphorylase, liver form

5

8

High-throughput

0.940

High

539507

PYGM
Glycogen phosphorylase, muscle form

4

8

High-throughput

0.894

High

539506

PYGB
Glycogen phosphorylase, brain form

1

8

High-throughput

0.698

High

329503

STBD1
Starch-binding domain-containing protein 1

3

2

High-throughput

0.667

High

539515

NTF3
Neurotrophin-3

2

1

High-throughput

0.611

High

539559

ZFP41
Zinc finger protein 41 homolog

3

1

High-throughput

0.609

High

539552

PPR3B
Protein phosphatase 1 regulatory subunit 3B

3

6

High-throughput

0.607

High

539535

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

2

2

High-throughput

0.601

High

240589

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

539529

TERA
Transitional endoplasmic reticulum ATPase

2

1

High-throughput

0.571

High

539540

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

1

High-throughput

0.552

High

539553

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

0

High-throughput

0.549

High

192007

GLYG2
Glycogenin-2

1

1

High-throughput

0.536

High

225523

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

1

High-throughput

0.536

High

539511

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.536

High

539512

GYS1
Glycogen [starch] synthase, muscle

1

2

High-throughput

0.536

High

539526

GLYG
Glycogenin-1

1

1

High-throughput

0.536

High

539547

PPR3F
Protein phosphatase 1 regulatory subunit 3F

1

2

High-throughput

0.536

High

539565

GASP2
G-protein coupled receptor-associated sorting protein 2

1

2

High-throughput

0.536

High

539573

TX101
Testis-expressed protein 101

1

1

High-throughput

0.536

High

539580

HSPB8
Heat shock protein beta-8

1

2

High-throughput

0.536

High

105201

APRIO
Alternative prion protein

2

2

High-throughput

0.533

High

332734

EPM2A
Laforin

1

0

High-throughput

0.513

High

387778

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

0

High-throughput

0.513

High

426435

HMGN2
Non-histone chromosomal protein HMG-17

1

0

High-throughput

0.513

High

539521

GDE
Glycogen debranching enzyme

1

0

High-throughput

0.513

High

539551

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

539567

CERS2
Ceramide synthase 2

1

0

High-throughput

0.513

High

539576

BIN3
Bridging integrator 3

1

0

High-throughput

0.513

High

352892

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.493

High

178071

FYB1
FYN-binding protein 1

1

1

High-throughput

0.489

High

342069

PPR3D
Protein phosphatase 1 regulatory subunit 3D

1

6

High-throughput

0.489

High

539528

PMS1
PMS1 protein homolog 1

1

1

High-throughput

0.489

High

539544

CXB7
Gap junction beta-7 protein

1

1

High-throughput

0.489

High

539510

ACTN1
Alpha-actinin-1

1

0

Small-scale

0.480

High

323132

TRI37
E3 ubiquitin-protein ligase TRIM37

1

4

High-throughput

0.479

High

484031

PGFRB
Platelet-derived growth factor receptor beta

1

4

High-throughput

0.479

High

488384

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

1

Small-scale

0.479

High

536376

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

539517

PML
Protein PML

1

2

High-throughput

0.479

High

539519

MCM5
DNA replication licensing factor MCM5

1

5

High-throughput

0.479

High

539525

MLH1
DNA mismatch repair protein Mlh1

1

1

High-throughput

0.479

High

539527

MCM2
DNA replication licensing factor MCM2

1

5

High-throughput

0.479

High

539530

H2B1D
Histone H2B type 1-D

1

1

High-throughput

0.479

High

539537

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.479

High

539538

EEA1
Early endosome antigen 1

1

1

High-throughput

0.479

High

539548

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

539555

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.479

High

539556

EMC5
ER membrane protein complex subunit 5

1

1

High-throughput

0.479

High

539558

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.479

High

539569

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

539571

H2B1L
Histone H2B type 1-L

1

1

High-throughput

0.479

High

539574

SENP3
Sentrin-specific protease 3

1

1

Small-scale

0.479

High

539575

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

539577

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

539579

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

400194

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

446589

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

539508

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

539509

SKI
Ski oncogene

1

0

Small-scale

0.458

High

539518

UFO
Tyrosine-protein kinase receptor UFO

1

0

High-throughput

0.458

High

539533

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.458

High

539560

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

539561

T185A
Transmembrane protein 185A

1

0

High-throughput

0.458

High

539563

CEMIP
Cell migration-inducing and hyaluronan-binding protein

1

0

Small-scale

0.458

High

254768

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.457

High

126975

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

High-throughput

0.445

High

528947

TAU
Microtubule-associated protein tau

1

9

High-throughput

0.445

High

539531

SMS
Somatostatin

1

1

Small-scale

0.445

High

539581

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

259354

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.437

High

371022

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

521512

H14
Histone H1.4

1

1

High-throughput

0.437

High

539513

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

539514

VGFR1
Vascular endothelial growth factor receptor 1

1

3

High-throughput

0.437

High

539516

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

539520

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

539523

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

3

High-throughput

0.437

High

539532

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.437

High

539543

FBX42
F-box only protein 42

1

1

High-throughput

0.437

High

539562

COP1
E3 ubiquitin-protein ligase COP1

1

1

High-throughput

0.437

High

539564

DPF3
Zinc finger protein DPF3

1

1

Small-scale

0.437

High

539572

FSD1
Fibronectin type III and SPRY domain-containing protein 1

1

7

High-throughput

0.437

High

404637

PRIO
Major prion protein

1

0

High-throughput

0.426

High

539536

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

539546

OLFM4
Olfactomedin-4

1

0

High-throughput

0.426

High

415987

CP1A1
Cytochrome P450 1A1

2

0

High-throughput

0.318

High

346701

NDST3
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3

1

0

High-throughput

0.279

Low

539522

PDE6B
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

1

0

High-throughput

0.279

Low

539534

CD69
Early activation antigen CD69

1

0

High-throughput

0.279

Low

539541

CTSRE
Cation channel sperm-associated auxiliary subunit epsilon

1

0

High-throughput

0.279

Low

539542

KIF24
Kinesin-like protein KIF24

1

0

High-throughput

0.279

Low

539549

CDHR3
Cadherin-related family member 3

1

0

High-throughput

0.279

Low

539554

SUGP1
SURP and G-patch domain-containing protein 1

1

0

High-throughput

0.279

Low

539566

TMA16
Translation machinery-associated protein 16

1

0

High-throughput

0.279

Low

94713

STMP1
Short transmembrane mitochondrial protein 1

1

0

High-throughput

0.249

Low

411256

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

539524

DHB3
17-beta-hydroxysteroid dehydrogenase type 3

1

0

High-throughput

0.249

Low

539539

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

539545

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.249

Low

539550

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

0

Small-scale

0.249

Low

539557

AR6P6
ADP-ribosylation factor-like protein 6-interacting protein 6

1

0

High-throughput

0.249

Low

539568

LIN37
Protein lin-37 homolog

1

0

High-throughput

0.249

Low

539570

CCNL2
Cyclin-L2

1

0

High-throughput

0.249

Low

539578

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

213054

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.232

Low

262204

SCN2B
Sodium channel regulatory subunit beta-2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025