Protein: DHB1
17-beta-hydroxysteroid dehydrogenase type 1 (17-beta-HSD 1) (EC 1.1.1.51) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Estradiol 17-beta-dehydrogenase 1) (EC 1.1.1.62) (Placental 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 28C member 1)

Gene: DHB1, HSD17B1
Organism: Homo sapiens
Interactions: 18
UniProt ID: P14061

Gene Ontology (top 5):
GO:0003824 - catalytic activity
GO:0004303 - estradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO:0005496 - steroid binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

488198

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

0

High-throughput

0.580

High

569445

DHB1
17-beta-hydroxysteroid dehydrogenase type 1

1

17

Small-scale

0.575

High

483878

HMOX1
Heme oxygenase 1

1

1

High-throughput

0.536

High

569446

RAB3B
Ras-related protein Rab-3B

1

1

High-throughput

0.536

High

569450

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

10

High-throughput

0.536

High

569451

RN5A
2-5A-dependent ribonuclease

1

2

High-throughput

0.536

High

569456

NOCT
Nocturnin

1

1

High-throughput

0.536

High

238371

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.513

High

569454

AF1L1
Actin filament-associated protein 1-like 1

1

0

High-throughput

0.513

High

569455

PDLI5
PDZ and LIM domain protein 5

1

0

High-throughput

0.513

High

569448

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

Small-scale

0.501

High

333438

MPZL1
Myelin protein zero-like protein 1

1

3

High-throughput

0.489

High

569447

GPDM
Glycerol-3-phosphate dehydrogenase, mitochondrial

1

4

High-throughput

0.489

High

569449

IL5RA
Interleukin-5 receptor subunit alpha

1

2

High-throughput

0.489

High

569452

EMB
Embigin

1

8

High-throughput

0.489

High

355061

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

1

0

Small-scale

0.438

High

569453

MCU
Calcium uniporter protein, mitochondrial

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025