Protein: MCU
Calcium uniporter protein, mitochondrial (HsMCU) (Coiled-coil domain-containing protein 109A)

Gene: MCU
Organism: Homo sapiens
Interactions: 203
UniProt ID: Q8NE86

Gene Ontology (top 5):
GO:0005262 - calcium channel activity
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0006851 - mitochondrial calcium ion transmembrane transport
GO:0015292 - uniporter activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1337192

MCU
Calcium uniporter protein, mitochondrial

3

6

Small-scale

0.834

High

1337232

EMRE
Essential MCU regulator, mitochondrial

3

0

Small-scale

0.809

High

1337218

MICU1
Calcium uptake protein 1, mitochondrial

6

2

Small-scale

0.721

High

1142508

PDCD1
Programmed cell death protein 1

2

0

High-throughput

0.679

High

1086051

ASPH
Aspartyl/asparaginyl beta-hydroxylase

3

1

High-throughput

0.662

High

988535

RAC1
Ras-related C3 botulinum toxin substrate 1

3

6

High-throughput

0.650

High

1315580

MICU2
Calcium uptake protein 2, mitochondrial

3

2

Small-scale

0.624

High

1337240

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

6

High-throughput

0.618

High

1163483

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

2

1

High-throughput

0.611

High

418707

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

3

1

High-throughput

0.609

High

771181

APJ
Apelin receptor

2

2

High-throughput

0.574

High

1196204

S22A6
Solute carrier family 22 member 6

2

1

High-throughput

0.574

High

653450

HEMH
Ferrochelatase, mitochondrial

2

1

High-throughput

0.571

High

1337204

BAD
Bcl2-associated agonist of cell death

2

0

High-throughput

0.547

High

1123353

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.536

High

901400

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.513

High

1310242

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1337197

HUMMR
Protein MGARP

1

0

High-throughput

0.513

High

182674

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.489

High

183951

S22A2
Solute carrier family 22 member 2

1

1

High-throughput

0.489

High

378640

IL2RA
Interleukin-2 receptor subunit alpha

1

1

High-throughput

0.489

High

833839

P2RY2
P2Y purinoceptor 2

1

3

High-throughput

0.489

High

1270839

SV2A
Synaptic vesicle glycoprotein 2A

1

2

High-throughput

0.489

High

1337214

SEC62
Translocation protein SEC62

1

1

High-throughput

0.489

High

1337217

CML1
Chemerin-like receptor 1

1

3

High-throughput

0.489

High

1337229

KLK15
Kallikrein-15

1

2

High-throughput

0.489

High

75997

B4DEF8
Large ribosomal subunit protein mL45

1

1

High-throughput

0.479

High

127517

NDUS8
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

1

1

High-throughput

0.479

High

143876

NDKM
Nucleoside diphosphate kinase, mitochondrial

1

1

High-throughput

0.479

High

209793

NDUS4
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

1

1

High-throughput

0.479

High

221618

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

1

High-throughput

0.479

High

223848

NDUA2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

1

3

High-throughput

0.479

High

256335

RT14
Small ribosomal subunit protein uS14m

1

1

High-throughput

0.479

High

269030

ABCB7
Iron-sulfur clusters transporter ABCB7, mitochondrial

1

1

High-throughput

0.479

High

275329

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

1

High-throughput

0.479

High

275697

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

1

1

High-throughput

0.479

High

278701

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

1

High-throughput

0.479

High

283913

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

1

High-throughput

0.479

High

322272

GLSK
Glutaminase kidney isoform, mitochondrial

1

1

High-throughput

0.479

High

328553

NDUA7
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

1

1

High-throughput

0.479

High

329308

LETM1
Mitochondrial proton/calcium exchanger protein

1

1

High-throughput

0.479

High

359694

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

1

High-throughput

0.479

High

360448

COX2
Cytochrome c oxidase subunit 2

1

1

High-throughput

0.479

High

552044

ADT1
ADP/ATP translocase 1

1

1

High-throughput

0.479

High

560022

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

1

High-throughput

0.479

High

568453

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

581176

RAC2
Ras-related C3 botulinum toxin substrate 2

1

5

High-throughput

0.479

High

622220

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

1

High-throughput

0.479

High

634136

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

1

High-throughput

0.479

High

665643

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

1

High-throughput

0.479

High

702631

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

1

High-throughput

0.479

High

733962

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

3

High-throughput

0.479

High

760970

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

1

High-throughput

0.479

High

766705

PHB1
Prohibitin 1

1

3

High-throughput

0.479

High

788107

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

4

High-throughput

0.479

High

888725

ACOT2
Acyl-coenzyme A thioesterase 2, mitochondrial

1

3

High-throughput

0.479

High

890987

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

1

High-throughput

0.479

High

902532

RT29
Small ribosomal subunit protein mS29

1

1

High-throughput

0.479

High

914671

RM12
Large ribosomal subunit protein bL12m

1

2

High-throughput

0.479

High

940025

NDUV3
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

1

1

High-throughput

0.479

High

941686

NDUA6
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

1

1

High-throughput

0.479

High

1011127

RT22
Small ribosomal subunit protein mS22

1

1

High-throughput

0.479

High

1011321

RT25
Small ribosomal subunit protein mS25

1

1

High-throughput

0.479

High

1011487

RT10
Small ribosomal subunit protein uS10m

1

1

High-throughput

0.479

High

1011665

RT35
Small ribosomal subunit protein mS35

1

1

High-throughput

0.479

High

1011846

RT05
Small ribosomal subunit protein uS5m

1

1

High-throughput

0.479

High

1012076

KGD4
Alpha-ketoglutarate dehydrogenase component 4

1

1

High-throughput

0.479

High

1012557

RT34
Small ribosomal subunit protein mS34

1

1

High-throughput

0.479

High

1012727

RT06
Small ribosomal subunit protein bS6m

1

1

High-throughput

0.479

High

1012903

RT09
Small ribosomal subunit protein uS9m

1

1

High-throughput

0.479

High

1035419

ODO1
2-oxoglutarate dehydrogenase complex component E1

1

2

High-throughput

0.479

High

1094062

RM28
Large ribosomal subunit protein bL28m

1

1

High-throughput

0.479

High

1104018

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.479

High

1104740

NNTM
NAD(P) transhydrogenase, mitochondrial

1

1

High-throughput

0.479

High

1141513

OXA1L
Mitochondrial inner membrane protein OXA1L

1

1

High-throughput

0.479

High

1162192

NDUA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

1

1

High-throughput

0.479

High

1164474

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.479

High

1215599

ATPF1
ATP synthase mitochondrial F1 complex assembly factor 1

1

1

High-throughput

0.479

High

1235920

PDE12
2',5'-phosphodiesterase 12

1

1

High-throughput

0.479

High

1245969

ZNT9
Proton-coupled zinc antiporter SLC30A9, mitochondrial

1

2

High-throughput

0.479

High

1287623

ACOT1
Acyl-coenzyme A thioesterase 1

1

3

High-throughput

0.479

High

1312711

RM41
Large ribosomal subunit protein mL41

1

1

High-throughput

0.479

High

1323207

NDUF2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2

1

1

High-throughput

0.479

High

1328238

RM50
Large ribosomal subunit protein mL50

1

1

High-throughput

0.479

High

1331643

RM43
Large ribosomal subunit protein mL43

1

3

High-throughput

0.479

High

1337196

S2540
Mitochondrial glutathione transporter SLC25A40

1

3

High-throughput

0.479

High

1337200

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

1

High-throughput

0.479

High

1337201

RT4I1
NAD(P)H oxidoreductase RTN4IP1, mitochondrial

1

1

High-throughput

0.479

High

1337202

RT27
Small ribosomal subunit protein mS27

1

1

High-throughput

0.479

High

1337203

RT31
Small ribosomal subunit protein mS31

1

1

High-throughput

0.479

High

1337206

RM24
Large ribosomal subunit protein uL24m

1

1

High-throughput

0.479

High

1337208

P5CR2
Pyrroline-5-carboxylate reductase 2

1

3

High-throughput

0.479

High

1337209

RT24
Small ribosomal subunit protein uS3m

1

1

High-throughput

0.479

High

1337210

PTCD3
Small ribosomal subunit protein mS39

1

1

High-throughput

0.479

High

1337211

MMAB
Corrinoid adenosyltransferase MMAB

1

1

High-throughput

0.479

High

1337216

PHB2
Prohibitin-2

1

3

High-throughput

0.479

High

1337219

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

1

High-throughput

0.479

High

1337220

TACO1
Translational activator of cytochrome c oxidase 1

1

1

High-throughput

0.479

High

1337221

CQ080
Mitochondrial nucleoid-associated protein 1

1

1

High-throughput

0.479

High

1337222

NDUF3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

1

1

High-throughput

0.479

High

1337224

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.479

High

1337225

RM04
Large ribosomal subunit protein uL4m

1

1

High-throughput

0.479

High

1337226

RT26
Small ribosomal subunit protein mS26

1

1

High-throughput

0.479

High

1337237

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

1337238

ATD3A
ATPase family AAA domain-containing protein 3A

1

4

High-throughput

0.479

High

1337242

NDUF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

1

1

High-throughput

0.479

High

1337245

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

1

High-throughput

0.479

High

1337246

NDUAC
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

1

1

High-throughput

0.479

High

1337249

STML2
Stomatin-like protein 2, mitochondrial

1

1

High-throughput

0.479

High

1337251

RT28
Small ribosomal subunit protein bS1m

1

1

High-throughput

0.479

High

1337252

RT17
Small ribosomal subunit protein uS17m

1

1

High-throughput

0.479

High

1337253

RT07
Small ribosomal subunit protein uS7m

1

1

High-throughput

0.479

High

1337254

RT02
Small ribosomal subunit protein uS2m

1

1

High-throughput

0.479

High

1337255

TIM16
Mitochondrial import inner membrane translocase subunit TIM16

1

1

High-throughput

0.479

High

1337256

RT23
Small ribosomal subunit protein mS23

1

1

High-throughput

0.479

High

1337258

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

1

High-throughput

0.479

High

1337259

RT18B
Small ribosomal subunit protein mS40

1

1

High-throughput

0.479

High

137766

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

641811

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

0

High-throughput

0.458

High

1337207

MCUR1
Mitochondrial calcium uniporter regulator 1

1

0

Small-scale

0.458

High

593598

GDC
Solute carrier family 25 member 16

1

2

High-throughput

0.445

High

916306

TXTP
Tricarboxylate transport protein, mitochondrial

1

3

High-throughput

0.445

High

1337228

S2532
Solute carrier family 25 member 32

1

2

High-throughput

0.445

High

126704

RHOD
Rho-related GTP-binding protein RhoD

1

9

High-throughput

0.437

High

466363

RHOC
Rho-related GTP-binding protein RhoC

1

6

High-throughput

0.437

High

824240

RL13A
Large ribosomal subunit protein uL13

1

1

High-throughput

0.437

High

890146

EI2BB
Translation initiation factor eIF2B subunit beta

1

2

High-throughput

0.437

High

910136

RND2
Rho-related GTP-binding protein RhoN

1

8

High-throughput

0.437

High

955386

CDC42
Cell division control protein 42 homolog

1

7

High-throughput

0.437

High

962281

RHOA
Transforming protein RhoA

1

7

High-throughput

0.437

High

978170

RHOB
Rho-related GTP-binding protein RhoB

1

7

High-throughput

0.437

High

1004853

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

1015610

RHOG
Rho-related GTP-binding protein RhoG

1

5

High-throughput

0.437

High

1124211

EI2BA
Translation initiation factor eIF2B subunit alpha

1

2

High-throughput

0.437

High

1151784

RHOH
Rho-related GTP-binding protein RhoH

1

7

High-throughput

0.437

High

1270906

RHOU
Rho-related GTP-binding protein RhoU

1

7

High-throughput

0.437

High

1337231

RHOJ
Rho-related GTP-binding protein RhoJ

1

7

High-throughput

0.437

High

1337233

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1337234

RHOF
Rho-related GTP-binding protein RhoF

1

8

High-throughput

0.437

High

1337247

EI2BD
Translation initiation factor eIF2B subunit delta

1

2

High-throughput

0.437

High

171518

S27A2
Long-chain fatty acid transport protein 2

1

2

High-throughput

0.407

High

351236

MOT3
Monocarboxylate transporter 3

1

3

High-throughput

0.407

High

1007447

S35B1
Solute carrier family 35 member B1

1

3

High-throughput

0.407

High

1131575

MFS10
Major facilitator superfamily domain-containing protein 10

1

3

High-throughput

0.407

High

1240905

S27A4
Long-chain fatty acid transport protein 4

1

2

High-throughput

0.407

High

1242175

NPAL3
NIPA-like protein 3

1

1

High-throughput

0.407

High

1337194

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

2

High-throughput

0.407

High

1337195

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

3

High-throughput

0.407

High

1337205

S35B4
Nucleotide sugar transporter SLC35B4

1

3

High-throughput

0.407

High

854552

S15A1
Solute carrier family 15 member 1

2

0

High-throughput

0.328

High

1128925

I13R2
Interleukin-13 receptor subunit alpha-2

2

0

High-throughput

0.328

High

1239250

ARMC6
Armadillo repeat-containing protein 6

2

0

High-throughput

0.328

High

1239406

IIGP5
Interferon-inducible GTPase 5

2

0

High-throughput

0.328

High

1329162

SC5A8
Sodium-coupled monocarboxylate transporter 1

2

0

High-throughput

0.328

High

1337223

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

2

0

High-throughput

0.328

High

1337227

NYX
Nyctalopin

2

0

High-throughput

0.318

High

1337230

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

2

0

High-throughput

0.305

High

539894

RALB
Ras-related protein Ral-B

2

0

High-throughput

0.298

High

1337193

TOIP2
Torsin-1A-interacting protein 2

2

0

High-throughput

0.288

High

125036

KCNK1
Potassium channel subfamily K member 1

1

0

High-throughput

0.279

Low

209617

SERA
D-3-phosphoglycerate dehydrogenase

1

0

High-throughput

0.279

Low

210463

MSH5
MutS protein homolog 5

1

0

High-throughput

0.279

Low

292377

RA51D
DNA repair protein RAD51 homolog 4

1

0

High-throughput

0.279

Low

372611

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.279

Low

569453

DHB1
17-beta-hydroxysteroid dehydrogenase type 1

1

0

High-throughput

0.279

Low

848529

MAGA8
Melanoma-associated antigen 8

1

0

High-throughput

0.279

Low

1053032

VMAT2
Synaptic vesicular amine transporter

1

0

High-throughput

0.279

Low

1158776

SYPL1
Synaptophysin-like protein 1

1

0

High-throughput

0.279

Low

1248898

EST3
Carboxylesterase 3

1

0

High-throughput

0.279

Low

1317072

CKLF8
CKLF-like MARVEL transmembrane domain-containing protein 8

1

0

High-throughput

0.279

Low

1337198

ZN526
Zinc finger protein 526

1

0

High-throughput

0.279

Low

1337212

CREL1
Protein disulfide isomerase CRELD1

1

0

High-throughput

0.279

Low

1337213

TR13C
Tumor necrosis factor receptor superfamily member 13C

1

0

High-throughput

0.279

Low

1337236

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

0

High-throughput

0.279

Low

1337243

CC167
Coiled-coil domain-containing protein 167

1

0

High-throughput

0.279

Low

1337244

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.279

Low

1337257

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.279

Low

1337248

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.269

Low

106303

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

157630

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

589192

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

695975

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

768675

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

831089

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

879281

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

927068

ATX3
Ataxin-3

1

0

Small-scale

0.249

Low

1140581

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

1156785

E2F4
Transcription factor E2F4

1

0

High-throughput

0.249

Low

1178260

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1254705

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1326273

NIN
Ninein

1

0

High-throughput

0.249

Low

1337199

TM263
Transmembrane protein 263

1

0

High-throughput

0.249

Low

1337215

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.249

Low

1337239

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.249

Low

1337241

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

0

High-throughput

0.249

Low

1337260

COL10
Collectin-10

1

0

High-throughput

0.249

Low

255129

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

1175879

TM241
UDP-N-acetylglucosamine transporter TMEM241

1

0

High-throughput

0.232

Low

1180291

ATG2A
Autophagy-related protein 2 homolog A

1

0

Small-scale

0.232

Low

1280796

S35E3
Solute carrier family 35 member E3

1

0

High-throughput

0.232

Low

1337235

S38AA
Solute carrier family 38 member 10

1

0

High-throughput

0.232

Low

1337250

S35A3
UDP-N-acetylglucosamine transporter

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025