Protein: HMOX1
Heme oxygenase 1 (HO-1) (EC 1.14.14.18) [Cleaved into: Heme oxygenase 1 soluble form]

Gene: HMOX1
Organism: Homo sapiens
Interactions: 143
UniProt ID: P09601

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001935 - endothelial cell proliferation
GO:0002246 - wound healing involved in inflammatory response
GO:0002686 - negative regulation of leukocyte migration
GO:0004392 - heme oxygenase (decyclizing) activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

483991

SRPRB
Signal recognition particle receptor subunit beta

4

3

High-throughput

0.691

High

483916

CGT
2-hydroxyacylsphingosine 1-beta-galactosyltransferase

3

1

High-throughput

0.667

High

483994

TX264
Testis-expressed protein 264

3

1

High-throughput

0.667

High

483875

HLAC
HLA class I histocompatibility antigen, C alpha chain

2

1

High-throughput

0.611

High

253140

MOT2
Monocarboxylate transporter 2

2

2

High-throughput

0.606

High

483892

CY561
Transmembrane ascorbate-dependent reductase CYB561

2

2

High-throughput

0.606

High

483915

STX1A
Syntaxin-1A

2

2

High-throughput

0.606

High

483918

AR13B
ADP-ribosylation factor-like protein 13B

2

2

High-throughput

0.606

High

483919

CYBR1
Plasma membrane ascorbate-dependent reductase CYBRD1

2

2

High-throughput

0.606

High

483920

F209A
Protein FAM209A

2

1

High-throughput

0.606

High

483951

F210B
Protein FAM210B, mitochondrial

2

1

High-throughput

0.606

High

483968

ELOV4
Very long chain fatty acid elongase 4

2

5

High-throughput

0.606

High

483969

ELOV6
Very long chain fatty acid elongase 6

2

5

High-throughput

0.606

High

483975

ELOV5
Very long chain fatty acid elongase 5

2

5

High-throughput

0.606

High

483986

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

3

High-throughput

0.606

High

483967

S39A8
Metal cation symporter ZIP8

3

2

High-throughput

0.604

High

483953

CDK15
Cyclin-dependent kinase 15

2

0

High-throughput

0.602

High

483965

ADA33
Disintegrin and metalloproteinase domain-containing protein 33

2

0

High-throughput

0.602

High

230243

CREB3
Cyclic AMP-responsive element-binding protein 3

2

1

High-throughput

0.590

High

483984

DD19B
ATP-dependent RNA helicase DDX19B

2

0

High-throughput

0.585

High

274964

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

2

0

High-throughput

0.580

High

483913

MSMO1
Methylsterol monooxygenase 1

2

0

High-throughput

0.580

High

483931

JAGN1
Protein jagunal homolog 1

2

0

High-throughput

0.580

High

483936

F174A
Membrane protein FAM174A

2

0

High-throughput

0.580

High

483949

T4S19
Transmembrane 4 L6 family member 19

2

0

High-throughput

0.580

High

483952

TLCD4
TLC domain-containing protein 4

2

0

High-throughput

0.580

High

483964

SC11C
Signal peptidase complex catalytic subunit SEC11C

2

0

High-throughput

0.580

High

483874

HMOX1
Heme oxygenase 1

1

1

Small-scale

0.575

High

483978

C5AR2
C5a anaphylatoxin chemotactic receptor 2

2

6

High-throughput

0.574

High

483944

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

Small-scale

0.561

High

483928

CD20B
Cell division cycle protein 20 homolog B

2

2

High-throughput

0.558

High

483877

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

1

High-throughput

0.553

High

483909

AQP6
Aquaporin-6

2

1

High-throughput

0.553

High

483937

GP152
Probable G-protein coupled receptor 152

2

11

High-throughput

0.553

High

483960

CRUM3
Protein crumbs homolog 3

2

1

High-throughput

0.553

High

483973

TM14B
Transmembrane protein 14B

2

1

High-throughput

0.553

High

483893

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.552

High

483974

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.549

High

483884

PE2R4
Prostaglandin E2 receptor EP4 subtype

1

3

High-throughput

0.541

High

483956

SMO
Protein smoothened

1

1

High-throughput

0.541

High

132555

UPK1A
Uroplakin-1a

1

2

High-throughput

0.536

High

229207

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

1

High-throughput

0.536

High

316476

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

1

High-throughput

0.536

High

349363

TSN15
Tetraspanin-15

1

1

High-throughput

0.536

High

483878

DHB1
17-beta-hydroxysteroid dehydrogenase type 1

1

1

High-throughput

0.536

High

483881

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

1

High-throughput

0.536

High

483885

HPCL1
Hippocalcin-like protein 1

1

1

High-throughput

0.536

High

483890

PTSS1
Phosphatidylserine synthase 1

1

1

High-throughput

0.536

High

483895

NCS1
Neuronal calcium sensor 1

1

1

High-throughput

0.536

High

483902

TAP1
Antigen peptide transporter 1

1

2

High-throughput

0.536

High

483925

PCAT2
Lysophosphatidylcholine acyltransferase 2

1

3

High-throughput

0.536

High

483927

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

4

High-throughput

0.536

High

483947

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.536

High

483950

BSCL2
Seipin

1

1

High-throughput

0.536

High

483957

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

1

High-throughput

0.536

High

483961

DERL1
Derlin-1

1

1

High-throughput

0.536

High

483962

PTSS2
Phosphatidylserine synthase 2

1

1

High-throughput

0.536

High

483977

STIM2
Stromal interaction molecule 2

1

2

High-throughput

0.536

High

483980

PHF11
PHD finger protein 11

1

1

High-throughput

0.536

High

483989

RN115
E3 ubiquitin-protein ligase RNF115

1

3

High-throughput

0.536

High

483886

EAA3
Excitatory amino acid transporter 3

2

0

High-throughput

0.528

High

409189

ARLY
Argininosuccinate lyase

1

0

High-throughput

0.518

High

164514

TNPO2
Transportin-2

1

0

High-throughput

0.513

High

276040

NIPS2
Protein NipSnap homolog 2

1

0

High-throughput

0.513

High

325268

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.513

High

483880

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.513

High

483891

AGRE5
Adhesion G protein-coupled receptor E5

1

0

High-throughput

0.513

High

483894

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

483897

SSBP2
Single-stranded DNA-binding protein 2

1

0

High-throughput

0.513

High

483898

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.513

High

483900

GCYA1
Guanylate cyclase soluble subunit alpha-1

1

0

High-throughput

0.513

High

483921

PLPP4
Phospholipid phosphatase 4

1

0

High-throughput

0.513

High

483923

NIPA3
Magnesium transporter NIPA3

1

0

High-throughput

0.513

High

483929

CERS3
Ceramide synthase 3

1

0

High-throughput

0.513

High

483945

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.513

High

483946

T106A
Transmembrane protein 106A

1

0

High-throughput

0.513

High

483948

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.513

High

483954

PIGS
GPI-anchor transamidase component PIGS

1

0

High-throughput

0.513

High

483963

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.513

High

483971

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.513

High

483987

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.513

High

483904

ILF3
Interleukin enhancer-binding factor 3

1

0

Small-scale

0.493

High

483883

CCR1
C-C chemokine receptor type 1

1

3

High-throughput

0.489

High

483888

CXA8
Gap junction alpha-8 protein

1

1

High-throughput

0.489

High

483907

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

7

High-throughput

0.489

High

385385

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

High-throughput

0.481

High

483970

SAR1A
Small COPII coat GTPase SAR1A

1

2

High-throughput

0.481

High

483988

TMX2
Thioredoxin-related transmembrane protein 2

1

2

High-throughput

0.481

High

178156

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.479

High

217745

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

373740

RASN
GTPase NRas

1

6

High-throughput

0.479

High

375110

RASK
GTPase KRas

1

6

High-throughput

0.479

High

483879

ZSC20
Zinc finger and SCAN domain-containing protein 20

1

2

High-throughput

0.479

High

483882

TIA1
Cytotoxic granule associated RNA binding protein TIA1

1

1

Small-scale

0.479

High

483896

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

483899

TIAR
Nucleolysin TIAR

1

1

Small-scale

0.479

High

483910

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

1

Small-scale

0.479

High

483933

RN149
E3 ubiquitin-protein ligase RNF149

1

4

High-throughput

0.479

High

483983

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.479

High

483935

TMIE
Transmembrane inner ear expressed protein

1

0

High-throughput

0.460

High

483992

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

1

0

High-throughput

0.460

High

211528

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

0

Small-scale

0.458

High

483876

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

483889

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

483901

NRG1
Pro-neuregulin-1, membrane-bound isoform

1

0

High-throughput

0.458

High

483903

PPID
Peptidyl-prolyl cis-trans isomerase D

1

0

High-throughput

0.458

High

483906

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

Small-scale

0.458

High

483908

SQSTM
Sequestosome-1

1

0

Small-scale

0.458

High

483912

ELAV1
ELAV-like protein 1

1

0

Small-scale

0.458

High

483940

ASB11
Ankyrin repeat and SOCS box protein 11

1

0

High-throughput

0.458

High

483942

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.458

High

483943

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

0

Small-scale

0.458

High

261062

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.445

High

483887

S6A12
Sodium- and chloride-dependent betaine transporter

1

2

High-throughput

0.445

High

483922

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.445

High

483930

S35F2
Solute carrier family 35 member F2

1

2

High-throughput

0.445

High

483934

ZNT7
Zinc transporter 7

1

1

High-throughput

0.445

High

483939

CTL1
Choline transporter-like protein 1

1

2

High-throughput

0.445

High

483941

S39A7
Zinc transporter SLC39A7

1

2

High-throughput

0.445

High

483985

S6A14
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

1

2

High-throughput

0.445

High

483993

MTCH2
Mitochondrial carrier homolog 2

1

1

High-throughput

0.445

High

483932

KASH5
Protein KASH5

1

1

High-throughput

0.439

High

483976

RN181
E3 ubiquitin-protein ligase RNF181

1

1

Small-scale

0.437

High

483979

ACHA9
Neuronal acetylcholine receptor subunit alpha-9

1

1

High-throughput

0.437

High

483911

CASP8
Caspase-8

1

0

High-throughput

0.426

High

483914

NF2L2
Nuclear factor erythroid 2-related factor 2

1

0

High-throughput

0.426

High

483938

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

1

0

High-throughput

0.426

High

483955

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.426

High

483958

PKP2
Plakophilin-2

1

0

High-throughput

0.426

High

483924

CLC4G
C-type lectin domain family 4 member G

1

2

Small-scale

0.407

High

483982

S39AA
Zinc transporter ZIP10

1

2

High-throughput

0.407

High

483966

LRC27
Leucine-rich repeat-containing protein 27

3

0

High-throughput

0.345

High

483972

TB22B
TBC1 domain family member 22B

2

0

High-throughput

0.328

High

483990

PCDC2
Protocadherin alpha-C2

2

0

High-throughput

0.328

High

483905

PDZ1I
PDZK1-interacting protein 1

2

0

High-throughput

0.316

High

483926

CPLX4
Complexin-4

2

0

High-throughput

0.316

High

254757

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.279

Low

260825

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

483959

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.279

Low

483917

SOAT
Sodium-dependent organic anion transporter

1

0

High-throughput

0.251

Low

293097

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

483981

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025