Protein: LOX5
Polyunsaturated fatty acid 5-lipoxygenase (EC 1.13.11.-) (Arachidonate 5-lipoxygenase) (5-LO) (5-lipoxygenase) (EC 1.13.11.34)

Gene: LOX5, ALOX5
Organism: Homo sapiens
Interactions: 86
UniProt ID: P09917

Gene Ontology (top 5):
GO:0001937 - negative regulation of endothelial cell proliferation
GO:0002232 - leukocyte chemotaxis involved in inflammatory response
GO:0002523 - leukocyte migration involved in inflammatory response
GO:0002540 - leukotriene production involved in inflammatory response
GO:0004051 - arachidonate 5-lipoxygenase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

488260

CEP63
Centrosomal protein of 63 kDa

5

1

High-throughput

0.725

High

488221

COTL1
Coactosin-like protein

6

0

Small-scale

0.706

High

488257

RUND1
RUN domain-containing protein 1

2

0

High-throughput

0.679

High

488273

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

4

0

High-throughput

0.679

High

488228

AMOT
Angiomotin

3

2

High-throughput

0.662

High

488203

TPP2
Tripeptidyl-peptidase 2

3

0

High-throughput

0.634

High

488263

OSB11
Oxysterol-binding protein-related protein 11

3

0

High-throughput

0.634

High

488269

DICER
Endoribonuclease Dicer

2

1

Small-scale

0.633

High

488213

NFKB2
Nuclear factor NF-kappa-B p100 subunit

2

3

High-throughput

0.628

High

488219

MTMR3
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3

2

1

High-throughput

0.628

High

488223

RB3GP
Rab3 GTPase-activating protein catalytic subunit

2

1

High-throughput

0.628

High

488224

KS6A2
Ribosomal protein S6 kinase alpha-2

2

3

High-throughput

0.628

High

488236

TRI65
E3 ubiquitin-protein ligase TRIM65

2

3

High-throughput

0.628

High

488259

KI16B
Kinesin-like protein KIF16B

2

1

High-throughput

0.628

High

488261

KKCC2
Calcium/calmodulin-dependent protein kinase kinase 2

2

3

High-throughput

0.628

High

488265

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

2

1

High-throughput

0.628

High

488271

RNF6
E3 ubiquitin-protein ligase RNF6

2

5

High-throughput

0.628

High

488237

HIPL2
HHIP-like protein 2

2

0

High-throughput

0.626

High

488212

GRB2
Growth factor receptor-bound protein 2

2

9

Small-scale

0.602

High

318188

DDHD2
Triacylglycerol hydrolase DDHD2

2

0

High-throughput

0.602

High

488220

CKAP5
Cytoskeleton-associated protein 5

2

0

High-throughput

0.602

High

488225

ITSN1
Intersectin-1

2

0

High-throughput

0.602

High

488227

ERC6L
DNA excision repair protein ERCC-6-like

2

0

High-throughput

0.602

High

488231

PMF1
Polyamine-modulated factor 1

2

0

High-throughput

0.602

High

488238

KDM3B
Lysine-specific demethylase 3B

2

0

High-throughput

0.602

High

488253

MADD
MAP kinase-activating death domain protein

2

0

High-throughput

0.602

High

488254

PSMF1
Proteasome inhibitor PI31 subunit

2

0

High-throughput

0.602

High

488256

PLPL2
Patatin-like phospholipase domain-containing protein 2

2

0

High-throughput

0.602

High

488268

TBD2B
TBC1 domain family member 2B

2

0

High-throughput

0.602

High

488207

MAPK2
MAP kinase-activated protein kinase 2

2

1

Small-scale

0.585

High

488198

DHB1
17-beta-hydroxysteroid dehydrogenase type 1

2

0

High-throughput

0.580

High

488205

LCN1
Lipocalin-1

2

0

High-throughput

0.580

High

488235

CC174
Coiled-coil domain-containing protein 174

2

0

High-throughput

0.580

High

488266

TBCD7
TBC1 domain family member 7

2

0

High-throughput

0.580

High

488246

CE57L
Centrosomal protein CEP57L1

2

1

High-throughput

0.578

High

488216

DMWD
Dystrophia myotonica WD repeat-containing protein

2

1

High-throughput

0.574

High

488215

REL
Proto-oncogene c-Rel

1

3

High-throughput

0.573

High

488226

LTC4S
Leukotriene C4 synthase

1

3

Small-scale

0.561

High

488244

AMOL1
Angiomotin-like protein 1

1

3

High-throughput

0.536

High

488200

AL5AP
Arachidonate 5-lipoxygenase-activating protein

1

3

Small-scale

0.527

High

488208

MEOX1
Homeobox protein MOX-1

1

3

High-throughput

0.523

High

488204

PUR8
Adenylosuccinate lyase

1

0

High-throughput

0.513

High

488211

ALR
FAD-linked sulfhydryl oxidase ALR

1

0

High-throughput

0.513

High

488217

CDC16
Cell division cycle protein 16 homolog

1

0

High-throughput

0.513

High

488240

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.493

High

421366

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

426011

PPBT
Alkaline phosphatase, tissue-nonspecific isozyme

1

0

Small-scale

0.480

High

488214

TF65
Transcription factor p65

1

3

Small-scale

0.479

High

488229

RN123
E3 ubiquitin-protein ligase RNF123

1

2

High-throughput

0.479

High

488267

IKZF3
Zinc finger protein Aiolos

1

1

Small-scale

0.479

High

488230

Q6FHY5
MEOX2 protein

1

2

High-throughput

0.470

High

488233

Q6P2R3
C6orf182 protein

1

1

High-throughput

0.470

High

488201

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

Small-scale

0.458

High

488202

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

0

Small-scale

0.458

High

488210

DHB4
Peroxisomal multifunctional enzyme type 2

1

0

Small-scale

0.458

High

488242

NAL10
NACHT, LRR and PYD domains-containing protein 10

1

0

Small-scale

0.458

High

462954

YES
Tyrosine-protein kinase Yes

1

6

Small-scale

0.445

High

473351

HCK
Tyrosine-protein kinase HCK

1

6

Small-scale

0.445

High

486649

FGR
Tyrosine-protein kinase Fgr

1

6

Small-scale

0.445

High

488199

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

2

Small-scale

0.445

High

488218

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

1

Small-scale

0.445

High

488209

MEOX2
Homeobox protein MOX-2

1

2

High-throughput

0.439

High

249411

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.426

High

488264

S35C2
Solute carrier family 35 member C2

1

0

High-throughput

0.426

High

488243

NUTM1
NUT family member 1

3

0

High-throughput

0.348

High

488247

SYCE1
Synaptonemal complex central element protein 1

2

0

High-throughput

0.341

High

488206

LSS
Lanosterol synthase

2

0

High-throughput

0.328

High

488222

COG2
Conserved oligomeric Golgi complex subunit 2

2

0

High-throughput

0.328

High

488232

ARMX5
Armadillo repeat-containing X-linked protein 5

2

0

High-throughput

0.328

High

488239

ERMP1
Endoplasmic reticulum metallopeptidase 1

2

0

High-throughput

0.328

High

488241

TEDC1
Tubulin epsilon and delta complex protein 1

2

0

High-throughput

0.328

High

488249

PALS1
Protein PALS1

2

0

High-throughput

0.328

High

488251

SLAI1
SLAIN motif-containing protein 1

2

0

High-throughput

0.328

High

488255

NICA
Nicastrin

2

0

High-throughput

0.328

High

488262

MND1
Meiotic nuclear division protein 1 homolog

2

0

High-throughput

0.328

High

488270

NEUR3
Sialidase-3

2

0

High-throughput

0.328

High

65485

OOEP
Oocyte-expressed protein homolog

2

0

High-throughput

0.316

High

225179

GATC
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial

2

0

High-throughput

0.316

High

488245

CJ067
Uncharacterized protein C10orf67, mitochondrial

2

0

High-throughput

0.316

High

488234

PDXD2
Putative pyridoxal-dependent decarboxylase domain-containing protein 2

2

0

High-throughput

0.288

High

488258

TV23C
Golgi apparatus membrane protein TVP23 homolog C

1

0

High-throughput

0.279

Low

488252

TGFA1
Transforming growth factor-beta receptor-associated protein 1

1

0

Small-scale

0.251

Low

488250

ZN433
Zinc finger protein 433

1

0

Small-scale

0.249

Low

488197

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

0

High-throughput

0.232

Low

488248

THMS1
Protein THEMIS

1

0

High-throughput

0.232

Low

488272

S35A3
UDP-N-acetylglucosamine transporter

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025