Protein: NSE1
Non-structural maintenance of chromosomes element 1 homolog (Non-SMC element 1 homolog) (EC 2.3.2.27)

Gene: NSE1, NSMCE1
Organism: Homo sapiens
Interactions: 36
UniProt ID: Q8WV22

Gene Ontology (top 5):
GO:0000724 - double-strand break repair via homologous recombination
GO:0000775 - chromosome, centromeric region
GO:0000781 - chromosome, telomeric region
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1357652

NSE3
Non-structural maintenance of chromosomes element 3 homolog

11

5

Small-scale

0.986

High

1357653

SMC6
Structural maintenance of chromosomes protein 6

7

3

Small-scale

0.966

High

1322851

EID3
EP300-interacting inhibitor of differentiation 3

6

2

Small-scale

0.949

High

1313290

SMC5
Structural maintenance of chromosomes protein 5

6

3

Small-scale

0.947

High

1357657

NSE4A
Non-structural maintenance of chromosomes element 4 homolog A

5

2

Small-scale

0.930

High

1357655

MAGF1
Melanoma-associated antigen F1

3

5

Small-scale

0.878

High

1357650

MAGBA
Melanoma-associated antigen B10

2

5

High-throughput

0.811

High

1357656

MAGE1
Melanoma-associated antigen E1

1

6

High-throughput

0.691

High

1357651

NSE2
E3 SUMO-protein ligase NSE2

5

0

Small-scale

0.686

High

1357649

ZN597
Zinc finger protein 597

4

0

High-throughput

0.661

High

1240756

PMF1
Polyamine-modulated factor 1

3

0

High-throughput

0.638

High

1311915

SLF2
SMC5-SMC6 complex localization factor protein 2

3

0

High-throughput

0.638

High

1357654

STN1
CST complex subunit STN1

3

0

High-throughput

0.638

High

1357647

NSE1
Non-structural maintenance of chromosomes element 1 homolog

1

0

Small-scale

0.586

High

848156

MAGA1
Melanoma-associated antigen 1

1

5

Small-scale

0.575

High

1146383

LRC41
Leucine-rich repeat-containing protein 41

1

0

High-throughput

0.513

High

508339

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

Small-scale

0.501

High

982259

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

0

Small-scale

0.480

High

1087891

NFIA
Nuclear factor 1 A-type

1

1

High-throughput

0.479

High

1088927

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

1129666

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

High-throughput

0.479

High

1133554

NFIX
Nuclear factor 1 X-type

1

1

High-throughput

0.479

High

1290613

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.479

High

315809

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

696039

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

768740

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

799328

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

998590

H31
Histone H3.1

1

0

High-throughput

0.458

High

1357648

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1357658

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

0

High-throughput

0.458

High

1336968

SIMC1
SUMO-interacting motif-containing protein 1

3

0

High-throughput

0.347

High

641635

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

0

High-throughput

0.300

High

1059052

TRHY
Trichohyalin

1

0

High-throughput

0.279

Low

1098651

SBP1
Methanethiol oxidase

1

0

High-throughput

0.279

Low

675094

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025