Protein: NSE2
E3 SUMO-protein ligase NSE2 (EC 2.3.2.-) (E3 SUMO-protein transferase NSE2) (MMS21 homolog) (hMMS21) (Non-structural maintenance of chromosomes element 2 homolog) (Non-SMC element 2 homolog)

Gene: NSE2, NSMCE2
Organism: Homo sapiens
Interactions: 37
UniProt ID: Q96MF7

Gene Ontology (top 5):
GO:0000722 - telomere maintenance via recombination
GO:0000724 - double-strand break repair via homologous recombination
GO:0000781 - chromosome, telomeric region
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1322857

EID3
EP300-interacting inhibitor of differentiation 3

4

3

Small-scale

0.691

High

1357651

NSE1
Non-structural maintenance of chromosomes element 1 homolog

5

0

Small-scale

0.686

High

1398147

SMC6
Structural maintenance of chromosomes protein 6

3

6

Small-scale

0.675

High

1397719

ZN597
Zinc finger protein 597

4

0

High-throughput

0.661

High

1313346

SMC5
Structural maintenance of chromosomes protein 5

2

6

Small-scale

0.625

High

238589

RAD21
Double-strand-break repair protein rad21 homolog

1

0

Small-scale

0.537

High

250775

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.513

High

608335

EGLN
Endoglin

1

0

High-throughput

0.513

High

1104463

ILK
Scaffold protein ILK

1

0

High-throughput

0.513

High

1247621

SAMD1
Sterile alpha motif domain-containing protein 1

1

0

High-throughput

0.513

High

1311917

SLF2
SMC5-SMC6 complex localization factor protein 2

1

0

High-throughput

0.513

High

1398145

NSE3
Non-structural maintenance of chromosomes element 3 homolog

1

0

High-throughput

0.513

High

1279701

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.493

High

896494

ETV1
ETS translocation variant 1

1

0

Small-scale

0.480

High

1398146

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

0

Small-scale

0.480

High

1398149

TSNAX
Translin-associated protein X

1

0

Small-scale

0.480

High

372870

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

799403

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

942829

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.458

High

1004986

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1033158

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

1045654

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1114035

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1197542

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

0

High-throughput

0.458

High

1314368

SLX4
Structure-specific endonuclease subunit SLX4

1

0

Small-scale

0.458

High

1398151

RN146
E3 ubiquitin-protein ligase RNF146

1

0

Small-scale

0.458

High

1398152

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

821187

TXLNA
Alpha-taxilin

3

0

High-throughput

0.352

High

1049673

1433F
14-3-3 protein eta

1

0

High-throughput

0.279

Low

1364107

TM9S4
Transmembrane 9 superfamily member 4

1

0

High-throughput

0.279

Low

1398148

SORT
Sortilin

1

0

High-throughput

0.279

Low

1398150

NIPS1
Protein NipSnap homolog 1

1

0

High-throughput

0.279

Low

109492

G5E9A7
DM1 locus, WD repeat containing

1

0

High-throughput

0.268

Low

246101

KIF1B
Kinesin-like protein KIF1B

1

0

High-throughput

0.268

Low

442449

GELS
Gelsolin

1

0

High-throughput

0.268

Low

650364

FGFR3
Fibroblast growth factor receptor 3

1

0

High-throughput

0.268

Low

686639

ELAV4
ELAV-like protein 4

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025