Protein: SIMC1
SUMO-interacting motif-containing protein 1 (Platform element for inhibition of autolytic degradation)

Gene: SIMC1
Organism: Homo sapiens
Interactions: 50
UniProt ID: Q8NDZ2

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0016605 - PML body
GO:0030017 - sarcomere
GO:0030414 - peptidase inhibitor activity
GO:0032184 - SUMO polymer binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1311912

SLF2
SMC5-SMC6 complex localization factor protein 2

2

0

High-throughput

0.631

High

1336971

SMC6
Structural maintenance of chromosomes protein 6

2

1

High-throughput

0.628

High

964376

SUMO2
Small ubiquitin-related modifier 2

2

1

Small-scale

0.613

High

1235378

KLH10
Kelch-like protein 10

2

0

High-throughput

0.602

High

1257247

RFPLB
Ret finger protein-like 4B

2

0

High-throughput

0.585

High

1336974

CAB45
45 kDa calcium-binding protein

2

0

High-throughput

0.585

High

1336979

C5AR2
C5a anaphylatoxin chemotactic receptor 2

2

2

High-throughput

0.574

High

714277

PML
Protein PML

2

0

High-throughput

0.559

High

966635

1433G
14-3-3 protein gamma

1

1

High-throughput

0.541

High

638473

FPR1
fMet-Leu-Phe receptor

1

2

High-throughput

0.536

High

1336970

NSE3
Non-structural maintenance of chromosomes element 3 homolog

1

1

High-throughput

0.536

High

1324566

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

High-throughput

0.513

High

1336985

ZN451
E3 SUMO-protein ligase ZNF451

1

0

High-throughput

0.501

High

133281

P2Y10
Putative P2Y purinoceptor 10

1

2

High-throughput

0.489

High

182671

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.489

High

848527

MAGA8
Melanoma-associated antigen 8

1

1

High-throughput

0.489

High

1101592

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

1

High-throughput

0.489

High

1336978

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

1

High-throughput

0.489

High

920124

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.486

High

995150

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.486

High

990514

1433Z
14-3-3 protein zeta/delta

1

1

High-throughput

0.481

High

991373

SUMO1
Small ubiquitin-related modifier 1

1

1

Small-scale

0.479

High

1313270

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

315788

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

1104223

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

0

High-throughput

0.458

High

1107938

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1113737

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1336975

DDX24
ATP-dependent RNA helicase DDX24

1

0

High-throughput

0.458

High

1336982

ZMYM2
Zinc finger MYM-type protein 2

1

0

High-throughput

0.458

High

1336983

XPO7
Exportin-7

1

0

High-throughput

0.458

High

997043

TBA4A
Tubulin alpha-4A chain

1

1

High-throughput

0.457

High

1259361

TBA1A
Tubulin alpha-1A chain

1

1

High-throughput

0.445

High

1336976

WNK1
Serine/threonine-protein kinase WNK1

1

0

High-throughput

0.438

High

166354

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

0

High-throughput

0.426

High

1108618

TBB3
Tubulin beta-3 chain

1

0

High-throughput

0.426

High

1336973

SLF1
SMC5-SMC6 complex localization factor protein 1

1

0

High-throughput

0.426

High

1336981

DJB11
DnaJ homolog subfamily B member 11

4

0

High-throughput

0.364

High

1336968

NSE1
Non-structural maintenance of chromosomes element 1 homolog

3

0

High-throughput

0.347

High

879807

NPY2R
Neuropeptide Y receptor type 2

2

0

High-throughput

0.328

High

1311496

BBS7
BBSome complex member BBS7

2

0

High-throughput

0.328

High

625504

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.279

Low

1037073

OC90
Otoconin-90

1

0

High-throughput

0.279

Low

1336969

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

1336972

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.279

Low

1336980

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

1336986

NPTN
Neuroplastin

1

0

High-throughput

0.279

Low

1336967

COP1
E3 ubiquitin-protein ligase COP1

1

0

High-throughput

0.249

Low

1336977

SACA1
Sperm acrosome membrane-associated protein 1

1

0

High-throughput

0.249

Low

844837

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.232

Low

1336984

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025