Protein: SLF2
SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1)

Gene: SLF2
Organism: Homo sapiens
Interactions: 39
UniProt ID: Q8IX21

Gene Ontology (top 5):
GO:0000724 - double-strand break repair via homologous recombination
GO:0000781 - chromosome, telomeric region
GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1311919

SMC6
Structural maintenance of chromosomes protein 6

3

1

Small-scale

0.683

High

1311910

SMC5
Structural maintenance of chromosomes protein 5

3

1

Small-scale

0.672

High

1311920

SLF1
SMC5-SMC6 complex localization factor protein 1

4

0

Small-scale

0.671

High

1311923

RAD18
E3 ubiquitin-protein ligase RAD18

3

0

High-throughput

0.646

High

1311915

NSE1
Non-structural maintenance of chromosomes element 1 homolog

3

0

High-throughput

0.638

High

1311912

SIMC1
SUMO-interacting motif-containing protein 1

2

0

High-throughput

0.631

High

680941

PSA1
Proteasome subunit alpha type-1

2

0

High-throughput

0.580

High

1121268

TRI14
Tripartite motif-containing protein 14

2

0

High-throughput

0.580

High

1218279

SMBT2
Scm-like with four MBT domains protein 2

2

0

High-throughput

0.580

High

714254

PML
Protein PML

2

0

High-throughput

0.559

High

1311916

OPTN
Optineurin

1

0

High-throughput

0.537

High

1311918

NSE3
Non-structural maintenance of chromosomes element 3 homolog

1

1

High-throughput

0.536

High

771908

CBS
Cystathionine beta-synthase

1

0

High-throughput

0.518

High

407653

S100B
Protein S100-B

1

0

High-throughput

0.513

High

594850

GCFC2
Intron Large complex component GCFC2

1

0

High-throughput

0.513

High

1311917

NSE2
E3 SUMO-protein ligase NSE2

1

0

High-throughput

0.513

High

1311924

NSE4A
Non-structural maintenance of chromosomes element 4 homolog A

1

0

High-throughput

0.513

High

943387

H2BFS
Histone H2B type F-S

1

1

High-throughput

0.479

High

1231821

H2B2C
Putative histone H2B type 2-C

1

1

High-throughput

0.479

High

414168

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

799278

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

855470

ATRX
Transcriptional regulator ATRX

1

0

Small-scale

0.458

High

883603

CENPA
Histone H3-like centromeric protein A

1

0

High-throughput

0.458

High

979952

H4
Histone H4

1

0

High-throughput

0.458

High

1133520

NFIX
Nuclear factor 1 X-type

1

0

High-throughput

0.458

High

1311911

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.458

High

1311913

NUP43
Nucleoporin Nup43

1

0

High-throughput

0.458

High

1311914

COP1
E3 ubiquitin-protein ligase COP1

1

0

High-throughput

0.458

High

1311921

TINF2
TERF1-interacting nuclear factor 2

1

0

High-throughput

0.458

High

1311922

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1311925

ZMYM2
Zinc finger MYM-type protein 2

1

0

High-throughput

0.458

High

1311926

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1311927

ZN451
E3 SUMO-protein ligase ZNF451

1

0

High-throughput

0.458

High

848796

MAGAA
Melanoma-associated antigen 10

1

1

High-throughput

0.445

High

322152

GLCE
D-glucuronyl C5-epimerase

1

0

High-throughput

0.279

Low

940355

ITA1
Integrin alpha-1

1

0

High-throughput

0.279

Low

516770

SCHI1
Schwannomin-interacting protein 1

1

0

High-throughput

0.249

Low

1049533

1433F
14-3-3 protein eta

1

0

High-throughput

0.249

Low

1237980

Q6NSK7
RIN3 protein

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025