Protein: DESM
Desmin

Gene: DESM, DES
Organism: Homo sapiens
Interactions: 131
UniProt ID: P17661

Gene Ontology (top 5):
GO:0005200 - structural constituent of cytoskeleton
GO:0005634 - nucleus
GO:0005635 - nuclear envelope
GO:0005829 - cytosol
GO:0005882 - intermediate filament

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

535322

GFAP
Glial fibrillary acidic protein

6

18

High-throughput

0.948

High

422142

NFL
Neurofilament light polypeptide

6

20

High-throughput

0.946

High

443316

VIME
Vimentin

5

19

High-throughput

0.934

High

569056

PERI
Peripherin

4

17

High-throughput

0.898

High

569123

SYNCI
Syncoilin

3

19

Small-scale

0.877

High

569045

DESM
Desmin

3

18

Small-scale

0.849

High

422344

NFM
Neurofilament medium polypeptide

2

20

High-throughput

0.811

High

166100

SYNEM
Synemin

2

20

Small-scale

0.799

High

280850

KRT37
Keratin, type I cuticular Ha7

2

20

High-throughput

0.783

High

318775

K2C75
Keratin, type II cytoskeletal 75

2

20

High-throughput

0.783

High

531443

K1C13
Keratin, type I cytoskeletal 13

2

20

High-throughput

0.783

High

569046

K1C15
Keratin, type I cytoskeletal 15

2

20

High-throughput

0.783

High

569052

K1C20
Keratin, type I cytoskeletal 20

2

20

High-throughput

0.783

High

569081

KT33B
Keratin, type I cuticular Ha3-II

2

20

High-throughput

0.783

High

569060

NEST
Nestin

1

19

High-throughput

0.691

High

569086

AINX
Alpha-internexin

1

19

High-throughput

0.691

High

569099

K2C73
Keratin, type II cytoskeletal 73

1

20

High-throughput

0.691

High

569092

PPR18
Phostensin

4

15

High-throughput

0.637

High

569093

CDC73
Parafibromin

2

1

Small-scale

0.614

High

569073

ECHP
Peroxisomal bifunctional enzyme

2

2

High-throughput

0.611

High

234188

PEPL
Periplakin

2

20

High-throughput

0.606

High

278222

PIAS2
E3 SUMO-protein ligase PIAS2

2

7

High-throughput

0.606

High

433246

YES
Tyrosine-protein kinase Yes

2

8

High-throughput

0.606

High

569049

DDX6
Probable ATP-dependent RNA helicase DDX6

2

9

High-throughput

0.606

High

569064

LBX1
Transcription factor LBX1

2

2

High-throughput

0.606

High

569069

RNF4
E3 ubiquitin-protein ligase RNF4

2

4

High-throughput

0.606

High

569084

TCEA2
Transcription elongation factor A protein 2

2

3

High-throughput

0.606

High

569127

NEK6
Serine/threonine-protein kinase Nek6

2

16

High-throughput

0.606

High

569133

ZMYM5
Zinc finger MYM-type protein 5

2

1

High-throughput

0.606

High

569134

BAG5
BAG family molecular chaperone regulator 5

2

6

High-throughput

0.606

High

569075

MTM1
Myotubularin

1

3

Small-scale

0.604

High

569115

AURKB
Aurora kinase B

2

9

Small-scale

0.595

High

569129

TBA8
Tubulin alpha-8 chain

2

2

High-throughput

0.584

High

569066

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

0

High-throughput

0.580

High

569106

SPT22
Spermatogenesis-associated protein 22

2

1

High-throughput

0.574

High

277819

DYSF
Dysferlin

1

3

High-throughput

0.568

High

569055

MLH1
DNA mismatch repair protein Mlh1

1

0

Small-scale

0.561

High

569132

DUX4
Double homeobox protein 4

1

5

High-throughput

0.561

High

62274

GG6L9
Golgin subfamily A member 6-like protein 9

2

20

High-throughput

0.553

High

569065

LMO4
LIM domain transcription factor LMO4

2

12

High-throughput

0.553

High

569088

C19L2
CWF19-like protein 2

2

2

High-throughput

0.553

High

569089

LONF3
LON peptidase N-terminal domain and RING finger protein 3

2

15

High-throughput

0.553

High

569107

CA216
UPF0500 protein C1orf216

2

3

High-throughput

0.553

High

569109

CT55
Cancer/testis antigen 55

2

3

High-throughput

0.553

High

569110

PIHD2
PIH1 domain-containing protein 2

2

4

High-throughput

0.553

High

569113

LENG1
Leukocyte receptor cluster member 1

2

3

High-throughput

0.553

High

569130

TFP11
Tuftelin-interacting protein 11

2

5

High-throughput

0.553

High

388211

HSPB1
Heat shock protein beta-1

1

9

High-throughput

0.541

High

417144

ENOA
Alpha-enolase

1

2

High-throughput

0.541

High

569103

CLIP4
CAP-Gly domain-containing linker protein 4

1

10

High-throughput

0.541

High

119849

RB27B
Ras-related protein Rab-27B

1

3

High-throughput

0.536

High

325619

LATS1
Serine/threonine-protein kinase LATS1

1

16

High-throughput

0.536

High

336352

SODC
Superoxide dismutase [Cu-Zn]

1

3

High-throughput

0.536

High

436672

GLI1
Zinc finger protein GLI1

1

11

High-throughput

0.536

High

440331

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

8

High-throughput

0.536

High

528496

CFTR
Cystic fibrosis transmembrane conductance regulator

1

17

High-throughput

0.536

High

569053

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

5

High-throughput

0.536

High

569059

NSF
Vesicle-fusing ATPase

1

7

High-throughput

0.536

High

569072

MECOM
Histone-lysine N-methyltransferase MECOM

1

7

High-throughput

0.536

High

569090

KLH22
Kelch-like protein 22

1

3

High-throughput

0.536

High

569098

CARM1
Histone-arginine methyltransferase CARM1

1

9

High-throughput

0.536

High

569117

NUP88
Nuclear pore complex protein Nup88

1

1

High-throughput

0.536

High

569121

GAN
Gigaxonin

1

16

High-throughput

0.536

High

551603

DESP
Desmoplakin

1

20

Small-scale

0.527

High

569116

DUX5
Double homeobox protein 5

1

18

High-throughput

0.527

High

310902

SNAPN
SNARE-associated protein Snapin

1

0

High-throughput

0.518

High

569058

HD
Huntingtin

1

9

High-throughput

0.515

High

569095

Q7KZS0
SUMO-conjugating enzyme UBC9

1

4

High-throughput

0.515

High

569062

RL34
Large ribosomal subunit protein eL34

1

0

High-throughput

0.513

High

569097

SPA24
Spermatogenesis-associated protein 24

1

0

High-throughput

0.513

High

569112

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.508

High

215071

DUX1
Double homeobox protein 1

1

20

High-throughput

0.506

High

358969

CRYAB
Alpha-crystallin B chain

1

9

Small-scale

0.501

High

569048

S10A1
Protein S100-A1

1

3

Small-scale

0.501

High

569102

PURA1
Adenylosuccinate synthetase isozyme 1

1

0

High-throughput

0.493

High

216899

KIF1C
Kinesin-like protein KIF1C

1

11

High-throughput

0.489

High

264832

MPPB
Mitochondrial-processing peptidase subunit beta

1

9

High-throughput

0.489

High

569074

MPPA
Mitochondrial-processing peptidase subunit alpha

1

9

High-throughput

0.489

High

569078

BMPR2
Bone morphogenetic protein receptor type-2

1

1

High-throughput

0.489

High

569087

RTN1
Reticulon-1

1

2

High-throughput

0.489

High

569096

TSN33
Tetraspanin-33

1

1

High-throughput

0.489

High

569100

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

20

High-throughput

0.489

High

569101

SYCE1
Synaptonemal complex central element protein 1

1

2

High-throughput

0.489

High

569104

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

20

High-throughput

0.489

High

569105

RN214
RING finger protein 214

1

2

High-throughput

0.489

High

380936

SHBG
Sex hormone-binding globulin

1

2

Small-scale

0.481

High

427839

CAN1
Calpain-1 catalytic subunit

1

6

Small-scale

0.481

High

569047

NEBU
Nebulin

1

18

Small-scale

0.481

High

569054

BRCA1
Breast cancer type 1 susceptibility protein

1

10

High-throughput

0.481

High

569068

UBC9
SUMO-conjugating enzyme UBC9

1

4

High-throughput

0.481

High

569085

ITSN1
Intersectin-1

1

20

High-throughput

0.481

High

569118

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.481

High

569125

PKHA5
Pleckstrin homology domain-containing family A member 5

1

16

High-throughput

0.481

High

148372

CTRO
Citron Rho-interacting kinase

1

15

High-throughput

0.479

High

209651

PRC1
Protein regulator of cytokinesis 1

1

11

High-throughput

0.479

High

226459

PRKN
E3 ubiquitin-protein ligase parkin

1

15

High-throughput

0.479

High

308391

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

434928

SP1
Transcription factor Sp1

1

7

Small-scale

0.479

High

569050

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

569063

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

15

High-throughput

0.479

High

569071

KIF23
Kinesin-like protein KIF23

1

15

High-throughput

0.479

High

569076

CUL4A
Cullin-4A

1

20

High-throughput

0.479

High

569082

KIF14
Kinesin-like protein KIF14

1

20

High-throughput

0.479

High

569083

PCBP1
Poly(rC)-binding protein 1

1

5

Small-scale

0.479

High

569119

SPRTN
DNA-dependent metalloprotease SPRTN

1

3

High-throughput

0.479

High

569122

CHM4B
Charged multivesicular body protein 4b

1

5

High-throughput

0.479

High

569124

ECT2
Protein ECT2

1

20

High-throughput

0.479

High

569128

ANLN
Anillin

1

12

High-throughput

0.479

High

569131

HDAC6
Histone deacetylase 6

1

12

High-throughput

0.479

High

569136

DTNA
Dystrobrevin alpha

1

5

Small-scale

0.479

High

569111

JPH3
Junctophilin-3

1

1

High-throughput

0.470

High

569061

MAPK2
MAP kinase-activated protein kinase 2

1

0

Small-scale

0.460

High

127710

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.458

High

569094

DUX4C
Double homeobox protein 4C

1

5

High-throughput

0.457

High

569126

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

3

High-throughput

0.457

High

320971

PTBP3
Polypyrimidine tract-binding protein 3

1

2

High-throughput

0.445

High

401378

JUN
Transcription factor Jun

1

13

High-throughput

0.445

High

547689

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

11

High-throughput

0.445

High

569051

BMI1
Polycomb complex protein BMI-1

1

14

High-throughput

0.445

High

569057

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

4

Small-scale

0.445

High

569067

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.445

High

569077

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

10

Small-scale

0.445

High

569079

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

4

High-throughput

0.445

High

569135

ITM2B
Integral membrane protein 2B

1

10

High-throughput

0.445

High

569080

RBM39
RNA-binding protein 39

1

5

High-throughput

0.437

High

569108

M1AP
Meiosis 1 arrest protein

2

0

High-throughput

0.316

High

569070

RT05
Small ribosomal subunit protein uS5m

1

0

High-throughput

0.279

Low

569091

CCD92
Coiled-coil domain-containing protein 92

1

0

High-throughput

0.279

Low

569120

RSH6A
Radial spoke head protein 6 homolog A

1

0

High-throughput

0.279

Low

569114

S47A1
Multidrug and toxin extrusion protein 1

1

0

High-throughput

0.269

Low


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Last updated: 15 Jul 2024