Protein: MED31
Mediator of RNA polymerase II transcription subunit 31 (Mediator complex subunit 31) (Mediator complex subunit SOH1) (hSOH1)

Gene: MED31
Organism: Homo sapiens
Interactions: 134
UniProt ID: Q9Y3C7

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006357 - regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

219530

MED7
Mediator of RNA polymerase II transcription subunit 7

7

4

High-throughput

0.969

High

1446564

MED4
Mediator of RNA polymerase II transcription subunit 4

4

2

High-throughput

0.912

High

1450398

MED17
Mediator of RNA polymerase II transcription subunit 17

3

1

High-throughput

0.871

High

239636

MED14
Mediator of RNA polymerase II transcription subunit 14

2

4

High-throughput

0.811

High

1391347

MED8
Mediator of RNA polymerase II transcription subunit 8

2

1

High-throughput

0.811

High

667522

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

0

High-throughput

0.770

High

49045

MED19
Mediator of RNA polymerase II transcription subunit 19

10

2

Small-scale

0.760

High

881632

CDK8
Cyclin-dependent kinase 8

8

5

Small-scale

0.752

High

1416413

CDK19
Cyclin-dependent kinase 19

7

5

High-throughput

0.750

High

1413646

MED10
Mediator of RNA polymerase II transcription subunit 10

6

2

Small-scale

0.738

High

1151315

MED1
Mediator of RNA polymerase II transcription subunit 1

5

1

Small-scale

0.722

High

1372221

MED12
Mediator of RNA polymerase II transcription subunit 12

5

2

High-throughput

0.722

High

1414155

MED18
Mediator of RNA polymerase II transcription subunit 18

5

1

High-throughput

0.722

High

1451901

MED29
Mediator of RNA polymerase II transcription subunit 29

5

1

Small-scale

0.722

High

666937

CCNC
Cyclin-C

5

1

High-throughput

0.718

High

1461617

MED23
Mediator of RNA polymerase II transcription subunit 23

4

2

High-throughput

0.694

High

1108420

MED21
Mediator of RNA polymerase II transcription subunit 21

5

0

High-throughput

0.690

High

1431409

MED28
Mediator of RNA polymerase II transcription subunit 28

5

0

High-throughput

0.688

High

1259083

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

3

2

High-throughput

0.675

High

1436795

MED20
Mediator of RNA polymerase II transcription subunit 20

3

1

High-throughput

0.675

High

336044

MED26
Mediator of RNA polymerase II transcription subunit 26

4

0

High-throughput

0.674

High

1460087

MED13
Mediator of RNA polymerase II transcription subunit 13

3

2

High-throughput

0.671

High

1451147

MED9
Mediator of RNA polymerase II transcription subunit 9

4

0

Small-scale

0.667

High

282433

MED24
Mediator of RNA polymerase II transcription subunit 24

3

1

High-throughput

0.667

High

1149723

MED22
Mediator of RNA polymerase II transcription subunit 22

3

0

High-throughput

0.646

High

287832

MED6
Mediator of RNA polymerase II transcription subunit 6

2

3

High-throughput

0.628

High

1241425

MED27
Mediator of RNA polymerase II transcription subunit 27

2

1

High-throughput

0.628

High

1295685

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

2

2

High-throughput

0.628

High

1393390

MED30
Mediator of RNA polymerase II transcription subunit 30

2

1

High-throughput

0.628

High

1453734

MED11
Mediator of RNA polymerase II transcription subunit 11

2

1

High-throughput

0.628

High

1490976

MED16
Mediator of RNA polymerase II transcription subunit 16

2

1

High-throughput

0.628

High

844120

HD
Huntingtin

2

0

High-throughput

0.604

High

188730

BIRC5
Baculoviral IAP repeat-containing protein 5

2

0

High-throughput

0.602

High

621803

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

0

High-throughput

0.602

High

622016

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

0

High-throughput

0.602

High

723149

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

0

High-throughput

0.602

High

976181

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

0

High-throughput

0.602

High

1401579

MED15
Mediator of RNA polymerase II transcription subunit 15

2

0

High-throughput

0.602

High

1160626

SMN
Survival motor neuron protein

2

0

High-throughput

0.598

High

1393426

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

2

0

High-throughput

0.580

High

1214703

Q5T911
Mediator of RNA polymerase II transcription subunit 4

1

2

High-throughput

0.575

High

415953

HSPB1
Heat shock protein beta-1

1

1

High-throughput

0.541

High

1092308

HSPB3
Heat shock protein beta-3

1

1

High-throughput

0.541

High

1106397

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

3

High-throughput

0.541

High

1259297

MED25
Mediator of RNA polymerase II transcription subunit 25

1

1

High-throughput

0.536

High

1287338

TAD2B
Transcriptional adapter 2-beta

1

4

High-throughput

0.536

High

332192

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

0

High-throughput

0.529

High

128088

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

0

High-throughput

0.518

High

193356

MAFG
Transcription factor MafG

1

0

High-throughput

0.518

High

257287

PQBP1
Polyglutamine-binding protein 1

1

0

High-throughput

0.518

High

334643

LYPA2
Acyl-protein thioesterase 2

1

0

High-throughput

0.518

High

538497

EGR2
E3 SUMO-protein ligase EGR2

1

0

High-throughput

0.518

High

590100

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.518

High

688196

EF1G
Elongation factor 1-gamma

1

0

High-throughput

0.518

High

829175

RFC5
Replication factor C subunit 5

1

0

High-throughput

0.518

High

895509

SPB9
Serpin B9

1

0

High-throughput

0.518

High

991002

UBE2B
Ubiquitin-conjugating enzyme E2 B

1

0

High-throughput

0.518

High

1015338

ERH
Enhancer of rudimentary homolog

1

0

High-throughput

0.518

High

1061926

TLE5
TLE family member 5

1

0

High-throughput

0.518

High

1150385

TGIF1
Homeobox protein TGIF1

1

0

High-throughput

0.518

High

1240791

PMF1
Polyamine-modulated factor 1

1

0

High-throughput

0.518

High

1333258

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

0

High-throughput

0.518

High

1395748

ZBT45
Zinc finger and BTB domain-containing protein 45

1

0

High-throughput

0.518

High

1407968

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.518

High

1414367

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

0

High-throughput

0.518

High

1431123

ASCC2
Activating signal cointegrator 1 complex subunit 2

1

0

High-throughput

0.518

High

1491185

EPN1
Epsin-1

1

0

High-throughput

0.518

High

192885

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

High-throughput

0.513

High

683542

IKBA
NF-kappa-B inhibitor alpha

1

0

High-throughput

0.513

High

787815

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.513

High

912159

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.513

High

923570

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.513

High

1057290

PRDX1
Peroxiredoxin-1

1

0

High-throughput

0.513

High

1239696

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

0

High-throughput

0.513

High

1243791

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.513

High

1313079

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.513

High

1413368

MTA3
Metastasis-associated protein MTA3

1

0

High-throughput

0.513

High

1491183

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.513

High

405568

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.486

High

628033

ANXA7
Annexin A7

1

0

High-throughput

0.486

High

652605

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

0

High-throughput

0.486

High

808204

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.486

High

1139165

DAZP2
DAZ-associated protein 2

1

0

High-throughput

0.486

High

1287705

RBM23
Probable RNA-binding protein 23

1

1

High-throughput

0.481

High

143346

NFIB
Nuclear factor 1 B-type

1

3

High-throughput

0.479

High

260641

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

283578

TAD2A
Transcriptional adapter 2-alpha

1

4

High-throughput

0.479

High

474394

NFIC
Nuclear factor 1 C-type

1

4

High-throughput

0.479

High

1045940

TF65
Transcription factor p65

1

3

High-throughput

0.479

High

1088117

NFIA
Nuclear factor 1 A-type

1

4

High-throughput

0.479

High

1133751

NFIX
Nuclear factor 1 X-type

1

4

High-throughput

0.479

High

401746

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

897436

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.458

High

920390

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.458

High

1089075

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1153953

SMAD2
Mothers against decapentaplegic homolog 2

1

0

Small-scale

0.458

High

1257849

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

1380279

FBXW7
F-box/WD repeat-containing protein 7

1

0

Small-scale

0.458

High

1400103

QKI
KH domain-containing RNA-binding protein QKI

1

0

High-throughput

0.458

High

1405581

TBX5
T-box transcription factor TBX5

1

0

High-throughput

0.458

High

1491184

RA54B
DNA repair and recombination protein RAD54B

1

0

High-throughput

0.458

High

1233280

Q6IA98
RNPC4 protein

1

1

High-throughput

0.457

High

95767

E5RFK5
Cyclin-C

1

1

High-throughput

0.445

High

1207513

Q5JWT2
Mediator of RNA polymerase II transcription subunit 23

1

2

High-throughput

0.445

High

1413837

HGH1
Protein HGH1 homolog

1

1

High-throughput

0.439

High

130664

SPT5H
Transcription elongation factor SPT5

1

0

High-throughput

0.438

High

1384716

Q96BK8
Protein HGH1 homolog

1

1

High-throughput

0.417

High

76447

B4DUB1
cyclin-dependent kinase

1

5

High-throughput

0.407

High

1364457

ELMO1
Engulfment and cell motility protein 1

3

0

High-throughput

0.347

High

1098693

SBP1
Methanethiol oxidase

2

0

High-throughput

0.323

High

131561

CACB4
Voltage-dependent L-type calcium channel subunit beta-4

1

0

High-throughput

0.282

High

261898

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.282

High

353642

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.282

High

599141

CBPE
Carboxypeptidase E

1

0

High-throughput

0.282

High

639660

SAT1
Diamine acetyltransferase 1

1

0

High-throughput

0.282

High

720078

HMOX2
Heme oxygenase 2

1

0

High-throughput

0.282

High

1040479

GSTM4
Glutathione S-transferase Mu 4

1

0

High-throughput

0.282

High

1050727

DYN1
Dynamin-1

1

0

High-throughput

0.282

High

1142470

PA1B3
Platelet-activating factor acetylhydrolase IB subunit alpha1

1

0

High-throughput

0.282

High

1157286

LAMA4
Laminin subunit alpha-4

1

0

High-throughput

0.282

High

1402884

ORAI2
Protein orai-2

1

0

High-throughput

0.282

High

1407642

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.282

High

1428187

TINAL
Tubulointerstitial nephritis antigen-like

1

0

High-throughput

0.282

High

1435106

WDCP
WD repeat and coiled-coil-containing protein

1

0

High-throughput

0.282

High

1491112

PHOCN
MOB-like protein phocein

1

0

High-throughput

0.282

High

125860

AP4M1
AP-4 complex subunit mu-1

1

0

High-throughput

0.279

Low

1398742

AP4AT
AP-4 complex accessory subunit Tepsin

1

0

High-throughput

0.279

Low

1460107

GPN3
GPN-loop GTPase 3

1

0

High-throughput

0.279

Low

1409743

F118B
Protein FAM118B

1

0

High-throughput

0.265

Low

387577

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.249

Low

1142038

EEA1
Early endosome antigen 1

1

0

High-throughput

0.249

Low

211690

LEU1
Leukemia-associated protein 1

1

0

High-throughput

0.238

Low

1452238

NSMA2
Sphingomyelin phosphodiesterase 3

1

0

High-throughput

0.238

Low

1335792

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025