Protein: PTN
Pleiotrophin (PTN) (Heparin-binding brain mitogen) (HBBM) (Heparin-binding growth factor 8) (HBGF-8) (Heparin-binding growth-associated molecule) (HB-GAM) (Heparin-binding neurite outgrowth-promoting factor) (HBNF) (Heparin-binding neurite outgrowth-promoting factor 1) (HBNF-1) (Osteoblast-specific factor 1) (OSF-1)

Gene: PTN
Organism: Homo sapiens
Interactions: 117
UniProt ID: P21246

Gene Ontology (top 5):
GO:0002232 - leukocyte chemotaxis involved in inflammatory response
GO:0002690 - positive regulation of leukocyte chemotaxis
GO:0004864 - protein phosphatase inhibitor activity
GO:0005178 - integrin binding
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

539458

ITAM
Integrin alpha-M

1

1

Small-scale

0.716

High

636700

PTN
Pleiotrophin

1

1

High-throughput

0.656

High

636773

UBQL4
Ubiquilin-4

2

6

High-throughput

0.620

High

636780

ALK
ALK tyrosine kinase receptor

2

1

Small-scale

0.595

High

636777

DJB11
DnaJ homolog subfamily B member 11

2

0

High-throughput

0.594

High

636726

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

0

High-throughput

0.580

High

636727

CHD3
Chromodomain-helicase-DNA-binding protein 3

2

1

High-throughput

0.566

High

636770

NEK6
Serine/threonine-protein kinase Nek6

1

1

Small-scale

0.549

High

636729

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

3

High-throughput

0.541

High

636756

CK5P2
CDK5 regulatory subunit-associated protein 2

1

1

High-throughput

0.541

High

127875

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

0

High-throughput

0.518

High

131546

CACB4
Voltage-dependent L-type calcium channel subunit beta-4

1

0

High-throughput

0.518

High

175321

PLXB2
Plexin-B2

1

0

High-throughput

0.518

High

248834

GSDME
Gasdermin-E

1

0

High-throughput

0.518

High

302243

STC2
Stanniocalcin-2

1

0

High-throughput

0.518

High

377105

GLHA
Glycoprotein hormones alpha chain

1

0

High-throughput

0.518

High

391181

FRIL
Ferritin light chain

1

0

High-throughput

0.518

High

452163

PDIA1
Protein disulfide-isomerase

1

0

High-throughput

0.518

High

479764

GSTP1
Glutathione S-transferase P

1

0

High-throughput

0.518

High

636707

T2FA
General transcription factor IIF subunit 1

1

0

High-throughput

0.518

High

636715

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.518

High

636718

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.518

High

636722

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

0

High-throughput

0.518

High

636723

BL1S1
Biogenesis of lysosome-related organelles complex 1 subunit 1

1

0

High-throughput

0.518

High

636728

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

High-throughput

0.518

High

636731

WFDC2
WAP four-disulfide core domain protein 2

1

0

High-throughput

0.518

High

636737

LAMA4
Laminin subunit alpha-4

1

0

High-throughput

0.518

High

636748

RIT1
GTP-binding protein Rit1

1

0

High-throughput

0.518

High

636749

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.518

High

636767

EVA1A
Protein eva-1 homolog A

1

0

High-throughput

0.518

High

636775

ITSN2
Intersectin-2

1

0

High-throughput

0.518

High

636779

TKNK
Tachykinin-3

1

0

High-throughput

0.518

High

636787

CAD10
Cadherin-10

1

0

High-throughput

0.518

High

636713

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

1

Small-scale

0.515

High

636724

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

2

Small-scale

0.501

High

636765

RN167
E3 ubiquitin-protein ligase RNF167

1

1

Small-scale

0.501

High

636711

PSB10
Proteasome subunit beta type-10

1

1

High-throughput

0.494

High

636714

AF9
Protein AF-9

1

1

High-throughput

0.494

High

636716

ATRX
Transcriptional regulator ATRX

1

1

High-throughput

0.494

High

636730

ASPP2
Apoptosis-stimulating of p53 protein 2

1

1

High-throughput

0.494

High

636754

CREL1
Protein disulfide isomerase CRELD1

1

2

High-throughput

0.494

High

605546

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

0

High-throughput

0.493

High

636710

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.493

High

636720

SERPH
Serpin H1

1

0

High-throughput

0.493

High

636747

KLK6
Kallikrein-6

1

0

High-throughput

0.493

High

228172

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.486

High

636719

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.486

High

636725

B2CL1
Bcl-2-like protein 1

1

0

High-throughput

0.486

High

636732

IMB1
Importin subunit beta-1

1

0

High-throughput

0.486

High

636758

FEZ1
Fasciculation and elongation protein zeta-1

1

0

High-throughput

0.486

High

636768

RM44
Large ribosomal subunit protein mL44

1

0

High-throughput

0.486

High

636717

BAG6
Large proline-rich protein BAG6

1

6

High-throughput

0.481

High

636781

UBQL1
Ubiquilin-1

1

6

High-throughput

0.481

High

424009

ITB3
Integrin beta-3

1

1

Small-scale

0.479

High

447978

ITAV
Integrin alpha-V

1

1

Small-scale

0.479

High

636703

PTPRZ
Receptor-type tyrosine-protein phosphatase zeta

1

4

Small-scale

0.479

High

636712

STAT3
Signal transducer and activator of transcription 3

1

1

Small-scale

0.479

High

332136

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

1

High-throughput

0.464

High

636704

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

1

High-throughput

0.464

High

636736

T22D1
TSC22 domain family protein 1

1

0

High-throughput

0.460

High

636705

CTNB1
Catenin beta-1

1

0

Small-scale

0.458

High

636734

EEA1
Early endosome antigen 1

1

0

High-throughput

0.458

High

636743

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

529067

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

636744

RBM23
Probable RNA-binding protein 23

1

1

High-throughput

0.439

High

636761

HGH1
Protein HGH1 homolog

1

1

High-throughput

0.439

High

370271

CYTA
Cystatin-A

1

0

High-throughput

0.438

High

636740

Q6IA98
RNPC4 protein

1

1

High-throughput

0.417

High

636750

Q96BK8
Protein HGH1 homolog

1

1

High-throughput

0.417

High

636764

TAF1D
TATA box-binding protein-associated factor RNA polymerase I subunit D

2

0

High-throughput

0.323

High

226700

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

2

0

High-throughput

0.319

High

131323

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

0

High-throughput

0.282

High

155729

TXND9
Thioredoxin domain-containing protein 9

1

0

High-throughput

0.282

High

207698

SGSM2
Small G protein signaling modulator 2

1

0

High-throughput

0.282

High

319137

ST65G
STAGA complex 65 subunit gamma

1

0

High-throughput

0.282

High

334997

ARI2
E3 ubiquitin-protein ligase ARIH2

1

0

High-throughput

0.282

High

428061

RLA1
Large ribosomal subunit protein P1

1

0

High-throughput

0.282

High

485840

COX6C
Cytochrome c oxidase subunit 6C

1

0

High-throughput

0.282

High

636701

SAT1
Diamine acetyltransferase 1

1

0

High-throughput

0.282

High

636702

GPDA
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

1

0

High-throughput

0.282

High

636709

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

0

High-throughput

0.282

High

636721

RACK1
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.282

High

636733

MD2BP
MAD2L1-binding protein

1

0

High-throughput

0.282

High

636735

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

High-throughput

0.282

High

636741

GLYAT
Glycine N-acyltransferase

1

0

High-throughput

0.282

High

636742

PMF1
Polyamine-modulated factor 1

1

0

High-throughput

0.282

High

636746

GIPC2
PDZ domain-containing protein GIPC2

1

0

High-throughput

0.282

High

636751

S2536
Solute carrier family 25 member 36

1

0

High-throughput

0.282

High

636753

HBAP1
HSPB1-associated protein 1

1

0

High-throughput

0.282

High

636755

NP1L5
Nucleosome assembly protein 1-like 5

1

0

High-throughput

0.282

High

636757

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.282

High

636762

BTBD2
BTB/POZ domain-containing protein 2

1

0

High-throughput

0.282

High

636766

CAAP1
Caspase activity and apoptosis inhibitor 1

1

0

High-throughput

0.282

High

636769

ABC3G
DNA dC->dU-editing enzyme APOBEC-3G

1

0

High-throughput

0.282

High

636771

MKKS
Molecular chaperone MKKS

1

0

High-throughput

0.282

High

636772

SAS10
Something about silencing protein 10

1

0

High-throughput

0.282

High

636774

ARL15
ADP-ribosylation factor-like protein 15

1

0

High-throughput

0.282

High

636776

BCCIP
BRCA2 and CDKN1A-interacting protein

1

0

High-throughput

0.282

High

636778

CRCT1
Cysteine-rich C-terminal protein 1

1

0

High-throughput

0.282

High

636782

DUS12
Dual specificity protein phosphatase 12

1

0

High-throughput

0.282

High

636783

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

High-throughput

0.282

High

636784

WASC3
WASH complex subunit 3

1

0

High-throughput

0.282

High

636786

SNCAP
Synphilin-1

1

0

High-throughput

0.282

High

636738

C19L2
CWF19-like protein 2

1

0

High-throughput

0.269

Low

125934

SMAP
Small acidic protein

1

0

High-throughput

0.265

Low

261763

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.265

Low

636745

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

High-throughput

0.265

Low

636752

GASP2
G-protein coupled receptor-associated sorting protein 2

1

0

High-throughput

0.265

Low

636759

BARD1
BRCA1-associated RING domain protein 1

1

0

High-throughput

0.265

Low

636760

CG025
UPF0415 protein C7orf25

1

0

High-throughput

0.265

Low

636763

MFRP
Membrane frizzled-related protein

1

0

Small-scale

0.261

Low

425994

CP2E1
Cytochrome P450 2E1

1

0

High-throughput

0.251

Low

636706

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.251

Low

636708

MSX2
Homeobox protein MSX-2

1

0

High-throughput

0.249

Low

636739

Q5T8Z1
COMMD3-BMI1 readthrough

1

0

High-throughput

0.238

Low

636785

SPIN1
Spindlin-1

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025