Protein: COFI
Cofilin (Actin-depolymerizing factor 1)

Gene: COFI, COF1
Organism: Saccharomyces cerevisiae S288C
Interactions: 98
UniProt ID: Q03048

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0006897 - endocytosis
GO:0007015 - actin filament organization
GO:0015629 - actin cytoskeleton

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

887656

ACT
Actin

20

20

Small-scale

0.989

High

805307

AIP1
Actin-interacting protein 1

3

6

Small-scale

0.664

High

568342

CAP
Adenylyl cyclase-associated protein

2

9

High-throughput

0.621

High

974363

COFI
Cofilin

1

10

Small-scale

0.621

High

521043

G6PI
Glucose-6-phosphate isomerase

2

0

High-throughput

0.569

High

343675

PMG1
Phosphoglycerate mutase 1

2

1

High-throughput

0.543

High

420330

CALM
Calmodulin

1

3

High-throughput

0.536

High

443949

CYAA
Adenylate cyclase

1

1

High-throughput

0.536

High

798331

TOS3
Serine/threonine-protein kinase TOS3

1

5

High-throughput

0.536

High

858855

IMB5
Importin subunit beta-5

1

2

High-throughput

0.536

High

965025

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

974365

CORO
Coronin-like protein

1

3

High-throughput

0.536

High

797548

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.533

High

761545

YCFI
Metal resistance protein YCF1

1

2

High-throughput

0.532

High

697113

RAD23
UV excision repair protein RAD23

1

1

High-throughput

0.515

High

567598

PHO81
Phosphate system positive regulatory protein PHO81

1

0

High-throughput

0.513

High

624312

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

1

0

High-throughput

0.513

High

797771

YFI6
Uncharacterized protein YFR016C

1

0

High-throughput

0.513

High

866339

APP1
Phosphatidate phosphatase APP1

1

0

High-throughput

0.513

High

974366

BUD20
Bud site selection protein 20

1

0

High-throughput

0.513

High

540374

BPT1
Bile pigment transporter 1

1

2

High-throughput

0.512

High

689442

YBT1
ATP-dependent bile acid permease

1

3

High-throughput

0.512

High

474272

NFT1
ABC transporter NFT1

1

3

High-throughput

0.494

High

594143

CKS1
Cyclin-dependent kinases regulatory subunit

1

0

High-throughput

0.493

High

974373

LAS17
Proline-rich protein LAS17

1

0

Small-scale

0.493

High

758697

TEM1
Protein TEM1

1

2

High-throughput

0.489

High

446219

MYO1
Myosin-1

1

5

Small-scale

0.481

High

731433

MID2
Cell wall integrity sensor MID2

1

1

Small-scale

0.481

High

784648

BNI1
Protein BNI1

1

0

High-throughput

0.480

High

334523

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

2

High-throughput

0.479

High

334791

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

2

High-throughput

0.479

High

334976

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

2

High-throughput

0.479

High

342767

ENO1
Enolase 1

1

2

High-throughput

0.479

High

342999

ENO2
Enolase 2

1

2

High-throughput

0.479

High

343425

TPIS
Triosephosphate isomerase

1

1

High-throughput

0.479

High

366778

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.479

High

389322

HXKA
Hexokinase-1

1

1

High-throughput

0.479

High

544295

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.479

High

700795

SMC1
Structural maintenance of chromosomes protein 1

1

1

High-throughput

0.470

High

337179

HIS1
ATP phosphoribosyltransferase

1

0

High-throughput

0.458

High

340255

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.458

High

340737

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.458

High

341729

HIS2
Histidine biosynthesis trifunctional protein [Includes: Phosphoribosyl-AMP cyclohydrolase

1

0

High-throughput

0.458

High

404367

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.458

High

411071

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.458

High

421787

KAD2
Adenylate kinase

1

0

High-throughput

0.458

High

423542

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

High-throughput

0.458

High

425042

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.458

High

537475

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.458

High

540629

CYPH
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.458

High

568131

TPM1
Tropomyosin-1

1

0

Small-scale

0.458

High

613832

TKT1
Transketolase 1

1

0

High-throughput

0.458

High

686902

P5CR
Pyrroline-5-carboxylate reductase

1

0

High-throughput

0.458

High

703718

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

727662

TCTP
Translationally-controlled tumor protein homolog

1

0

High-throughput

0.458

High

753245

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

0

High-throughput

0.458

High

753928

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

765565

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.458

High

783299

GPP1
Glycerol-1-phosphate phosphohydrolase 1

1

0

High-throughput

0.458

High

797104

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

853157

SKP1
Suppressor of kinetochore protein 1

1

0

Small-scale

0.458

High

974368

ZEO1
Protein ZEO1

1

0

High-throughput

0.458

High

520865

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.457

High

492222

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.445

High

494789

HSP72
Heat shock protein SSA2

1

4

High-throughput

0.445

High

512466

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.445

High

695376

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.445

High

769279

SSB2
Ribosome-associated molecular chaperone SSB2

1

4

High-throughput

0.445

High

474294

YK104
Putative uncharacterized protein YKR104W

1

3

High-throughput

0.439

High

336264

CCPR
Cytochrome c peroxidase, mitochondrial

1

1

Small-scale

0.437

High

336692

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.437

High

389412

HXKB
Hexokinase-2

1

1

High-throughput

0.437

High

707916

GCN1
eIF-2-alpha kinase activator GCN1

1

0

High-throughput

0.279

Low

873642

ORN
Oligoribonuclease, mitochondrial

1

0

High-throughput

0.279

Low

974364

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.279

Low

974369

DIA2
Protein DIA2

1

0

High-throughput

0.279

Low

747842

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

0

High-throughput

0.269

Low

772885

RIC1
Guanine nucleotide exchange factor subunit RIC1

1

0

High-throughput

0.269

Low

859841

PUS2
tRNA pseudouridine(27/28) synthase

1

0

High-throughput

0.269

Low

974367

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

0

High-throughput

0.261

Low

775572

MPH1
ATP-dependent DNA helicase MPH1

1

0

Small-scale

0.251

Low

971999

ULP1
Ubiquitin-like-specific protease 1

1

0

High-throughput

0.251

Low

542695

TAL1
Transaldolase

1

0

High-throughput

0.249

Low

572820

PDI
Protein disulfide-isomerase

1

0

High-throughput

0.249

Low

628396

SIS1
Protein SIS1

1

0

High-throughput

0.249

Low

663118

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

690599

EF1B
Elongation factor 1-beta

1

0

High-throughput

0.249

Low

745844

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

746079

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

0

High-throughput

0.249

Low

757014

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.249

Low

770154

MMF1
Protein MMF1, mitochondrial

1

0

High-throughput

0.249

Low

812093

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

866790

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

867514

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

0

High-throughput

0.249

Low

974370

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

974371

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.249

Low

974372

JID1
J domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024