Protein: THOP1
Thimet oligopeptidase (EC 3.4.24.15) (Endopeptidase 24.15) (MP78)

Gene: THOP1
Organism: Homo sapiens
Interactions: 57
UniProt ID: P52888

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0004222 - metalloendopeptidase activity
GO:0005758 - mitochondrial intermembrane space
GO:0005829 - cytosol
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

914935

THOP1
Thimet oligopeptidase

1

3

High-throughput

0.618

High

914960

OPTN
Optineurin

2

2

High-throughput

0.601

High

329434

EPN2
Epsin-2

2

0

High-throughput

0.580

High

532473

CH60
60 kDa heat shock protein, mitochondrial

2

0

High-throughput

0.576

High

914963

MPH6
M-phase phosphoprotein 6

2

0

High-throughput

0.551

High

914936

TTC3
E3 ubiquitin-protein ligase TTC3

1

0

High-throughput

0.518

High

914947

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.518

High

914969

EXOS3
Exosome complex component RRP40

1

0

High-throughput

0.513

High

914961

XAGE2
X antigen family member 2

1

1

High-throughput

0.489

High

914941

TRAF2
TNF receptor-associated factor 2

1

2

High-throughput

0.481

High

241167

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

468208

HS90B
Heat shock protein HSP 90-beta

1

1

High-throughput

0.479

High

914937

HDAC4
Histone deacetylase 4

1

1

High-throughput

0.479

High

914939

EXOSX
Exosome complex component 10

1

1

High-throughput

0.479

High

914940

EXOS9
Exosome complex component RRP45

1

3

High-throughput

0.479

High

914943

CUL3
Cullin-3

1

2

High-throughput

0.479

High

914945

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

914946

EXOS7
Exosome complex component RRP42

1

3

High-throughput

0.479

High

914948

EXOS6
Exosome complex component MTR3

1

5

High-throughput

0.479

High

914959

EXOS8
Exosome complex component RRP43

1

3

High-throughput

0.479

High

914967

EXOS4
Exosome complex component RRP41

1

4

High-throughput

0.479

High

914968

EXOS5
Exosome complex component RRP46

1

4

High-throughput

0.479

High

914973

EXOS1
Exosome complex component CSL4

1

1

High-throughput

0.479

High

252027

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

363016

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

914938

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

914944

EXOS2
Exosome complex component RRP4

1

0

High-throughput

0.458

High

914951

GGYF2
GRB10-interacting GYF protein 2

1

0

High-throughput

0.458

High

914955

DI3L1
DIS3-like exonuclease 1

1

0

High-throughput

0.458

High

914956

RSAD2
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

1

0

High-throughput

0.458

High

914966

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

914949

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

914950

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.445

High

105620

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

588272

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

694999

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

767763

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

914952

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

914972

TRI33
E3 ubiquitin-protein ligase TRIM33

1

1

High-throughput

0.437

High

261137

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.426

High

914953

DND1
Dead end protein homolog 1

1

0

High-throughput

0.426

High

330086

VENTX
Homeobox protein VENTX

1

1

High-throughput

0.407

High

914942

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.407

High

336590

PPN
Papilin

2

0

High-throughput

0.328

High

914962

DB118
Defensin beta 118

1

0

High-throughput

0.279

Low

914971

PALS2
Protein PALS2

1

0

High-throughput

0.251

Low

353134

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

411631

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

606480

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.249

Low

838684

MTREX
Exosome RNA helicase MTR4

1

0

High-throughput

0.249

Low

914954

FSAF1
40S small subunit processome assembly factor 1

1

0

High-throughput

0.249

Low

914957

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.249

Low

914958

TP4A1
Protein tyrosine phosphatase type IVA 1

1

0

High-throughput

0.249

Low

914970

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

914964

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low

914965

NUAK2
NUAK family SNF1-like kinase 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025