Protein: ESC
Polycomb protein esc (Protein extra sex combs)

Gene: ESC
Organism: Drosophila melanogaster
Interactions: 34
UniProt ID: Q24338

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0005700 - polytene chromosome
GO:0006357 - regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

837312

EZ
Histone-lysine N-methyltransferase E(z)

25

20

Small-scale

0.991

High

1173873

SUZ12
Polycomb protein Su(z)12

10

10

Small-scale

0.970

High

1173869

CAF1
Chromatin assembly factor 1 p55 subunit

9

19

Small-scale

0.967

High

1173867

ESC
Polycomb protein esc

3

16

Small-scale

0.886

High

381700

H3
Histone H3

2

16

Small-scale

0.812

High

1173868

PCL
Polycomb protein Pcl

6

20

Small-scale

0.729

High

1173872

HDAC1
Histone deacetylase HDAC1

5

20

Small-scale

0.727

High

1014830

H2A
Histone H2A

1

12

Small-scale

0.618

High

1173881

Q9VKD5
Polycomb protein esc

1

17

Small-scale

0.618

High

1173871

PHO
Polycomb protein PHO

2

10

Small-scale

0.584

High

1173885

JARD2
Jumonji, AT rich interactive domain protein 2

2

7

Small-scale

0.571

High

831796

CORTO
Centrosomal and chromosomal factor

1

0

Small-scale

0.561

High

683679

PC
Polycomb group protein Pc

2

18

Small-scale

0.552

High

1172332

HR78
Nuclear hormone receptor HR78

1

20

High-throughput

0.541

High

1173876

Q9VDF0
Hematopoietically expressed homeobox

1

9

High-throughput

0.541

High

1173880

Q9VJ27
Uncharacterized protein, isoform A

1

2

High-throughput

0.541

High

1173875

Q9VAI8
Doublesex-Mab related 99B

1

0

High-throughput

0.518

High

892327

TAF12
Transcription initiation factor TFIID subunit 12

1

3

High-throughput

0.508

High

713673

ABDA
Homeobox protein abdominal-A

1

4

High-throughput

0.481

High

1014314

UBX
Homeotic protein ultrabithorax

1

6

High-throughput

0.481

High

1173870

Q7KUL4
Intermediate neuroblasts defective

1

3

High-throughput

0.481

High

384800

HSP23
Heat shock protein 23

1

3

High-throughput

0.479

High

814654

PHP
Polyhomeotic-proximal chromatin protein

1

20

Small-scale

0.479

High

1064525

GAGA
Transcription activator GAGA

1

6

Small-scale

0.479

High

1173877

SAP18
Histone deacetylase complex subunit SAP18

1

3

Small-scale

0.479

High

1173878

SCM
Polycomb protein Scm

1

10

Small-scale

0.479

High

1173882

PIWI
Protein piwi

1

4

Small-scale

0.479

High

1173884

Q9VSZ3
LD31045p

1

8

Small-scale

0.479

High

1173883

Q9VPG7
G protein RhoBTB

1

16

High-throughput

0.464

High

355836

O96620
Intermediate neuroblasts defective protein

1

3

High-throughput

0.457

High

1173886

Q9W215
GEO03726p1

1

5

High-throughput

0.445

High

1173874

WARTS
Serine/threonine-protein kinase Warts

1

8

Small-scale

0.437

High

1173879

Q9VHT8
RE26525p

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025