Protein: C1R
Complement C1r subcomponent (EC 3.4.21.41) (Complement component 1 subcomponent r) [Cleaved into: Complement C1r subcomponent heavy chain (Complement C1r subcomponent chain A); Complement C1r subcomponent light chain (Complement C1r subcomponent chain B)]

Gene: C1R
Organism: Homo sapiens
Interactions: 17
UniProt ID: P00736

Gene Ontology (top 5):
GO:0004252 - serine-type endopeptidase activity
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0006955 - immune response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

366118

C1S
Complement C1s subcomponent

7

14

Small-scale

0.962

High

366116

C1R
Complement C1r subcomponent

3

15

Small-scale

0.853

High

366130

C1RL
Complement C1r subcomponent-like protein

2

16

High-throughput

0.811

High

366127

LRC15
Leucine-rich repeat-containing protein 15

1

12

High-throughput

0.691

High

366123

BIRC2
Baculoviral IAP repeat-containing protein 2

2

6

High-throughput

0.574

High

366125

DSG4
Desmoglein-4

1

11

High-throughput

0.536

High

366117

C1QA
Complement C1q subcomponent subunit A

1

10

Small-scale

0.479

High

366120

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

0

High-throughput

0.460

High

366124

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

366126

SULF2
Extracellular sulfatase Sulf-2

1

7

High-throughput

0.445

High

366122

EP300
Histone acetyltransferase p300

1

3

High-throughput

0.439

High

366121

TISD
mRNA decay activator protein ZFP36L2

1

2

High-throughput

0.437

High

366128

SNX27
Sorting nexin-27

1

3

High-throughput

0.437

High

366131

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.437

High

366119

EF1D
Elongation factor 1-delta

1

0

High-throughput

0.249

Low

366129

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025