HitPredict

Interactor 1: C1R (P00736)
Complement C1r subcomponent (EC 3.4.21.41) (Complement component 1 subcomponent r) [Cleaved into: Complement C1r subcomponent heavy chain (Complement C1r subcomponent chain A); Complement C1r subcomponent light chain (Complement C1r subcomponent chain B)]
Gene: C1R

Interactor 2: C1R (P00736)
Complement C1r subcomponent (EC 3.4.21.41) (Complement component 1 subcomponent r) [Cleaved into: Complement C1r subcomponent heavy chain (Complement C1r subcomponent chain A); Complement C1r subcomponent light chain (Complement C1r subcomponent chain B)]
Gene: C1R

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.72 1.00 0.853

The method score is based on:

Property Details
Experiments 11823416, 17996945, 20970424
Identification Methods x-ray crystallography, protease assay, nuclear magnetic resonance
Interaction Type association, direct interaction, protein cleavage

The annotation score is based on:

Property Details
Interacting Pfam domains CUB~CUB, CUB~FXa_inhibition, CUB~Sushi, CUB~Trypsin, FXa_inhibition~Trypsin, Sushi~Sushi, Sushi~Trypsin, Trypsin~Trypsin
Common GO terms GO:0004252 - serine-type endopeptidase activity
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0006955 - immune response
and 7 others

more...
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 705
Hs

1 705
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Last updated: 11Aug2025